Neuroprotective effects of <i>Levisticum officinale</i> on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties

Amraie, Esmaeil; Pouraboli, Iran; Rajaei, Ziba

doi:10.1039/d0fo01030h

Cited by 22 publications

(10 citation statements)

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“…[ 42 ] Brain oxidative damage is also considered an important mechanism for LPS-induced memory deficits. [ 15 26 ] In the present study, we observed that memory impairment caused by LPS was accompanied by brain tissue oxidative stress. LPS resulted in significantly increased levels of TBARS in the hippocampus and cerebral cortex, and decreased levels of total thiol concentration in the cortex, which were blocked by carvacrol.…”

Section: Discussionsupporting

confidence: 51%

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Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats

Rajaei

Amooheydari

Alaei

et al. 2022

Advanced Biomedical Research

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Background: Carvacrol is a natural phenolic monoterpene with anti-inflammatory and antioxidant bioactivities. Neuroinflammatory and oxidative stress responses play a crucial role in the pathogenesis of Alzheimer's disease. The present study examined the effect of carvacrol on brain tumor necrosis factor-alpha (TNF-α) level and oxidative stress as well as spatial learning and memory performances in lipopolysaccharide (LPS)-exposed rats. Materials and Methods: The rats were treated with either carvacrol (25 and 50 mg/kg) or Tween 80 for 2 weeks. Thereafter, LPS (1 mg/kg) or saline was intraperitoneally administered on days 15–19, 2 h before Morris water maze task, and treatments with carvacrol or Tween 80 were performed 30 min prior to behavioral testing. The level of TNF-α, lipid peroxidation, and total thiol concentration were measured in the hippocampus and cerebral cortex at the end of the experiment. Results: It was found that LPS-exposed rats exhibited spatial learning and memory dysfunction, which was accompanied by increased TNF-α level and lipid peroxidation, and decreased total thiol concentration in the hippocampus and/or cortex. Moreover, treatment with carvacrol at a dose of 25 mg/kg attenuated learning and memory impairments, decreased TNF-α and lipid peroxidation level in the hippocampus and cortex, and increased total thiol concentration in the cortex. Conclusion: Carvacrol exerts neuroprotective effects against LPS-induced spatial memory deficits through attenuating hippocampal TNF-α level and oxidative stress in rats.

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Section: Discussionsupporting

confidence: 51%

“…Recently, many nutraceuticals targeting neuroinflammatory and oxidative mediators have attracted consideration as an alternative for the prevention or treatment of neurodegenerative and neuroinflammatory diseases. [ 14 15 ]…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats

Rajaei

Amooheydari

Alaei

et al. 2022

Advanced Biomedical Research

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“…It has been long cultivated in Europe, with its leaves being used as a herb, roots as a vegetable, and seeds as a spice, especially in the southern European cuisine. It has a possible gonadotropic effect -androgenic, a relaxing effect on the myometrium, an increased effect on libido, but no effect on lactation is expressed (Amraie et al 2020).…”

Section: Gonadotropic Plants For Treatment Fibrocystic Breast Diseasementioning

confidence: 99%

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Sokolik

Prozorova

2022

RRP

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Introduction: Fibrocystic breast disease, commonly called fibrocystic breasts or fibrocystic change, is a benign (noncancerous) condition, which is the most common pathology in women of reproductive age. Treatment of fibrocystic breast disease and concomitant pathologies can involve using herbs. Materials and Methods: To make an analysis of literary sources on the development of fibrocystic breast disease in the pathogenesis of diseases of the female reproductive system (clinical human (75%) and animal studies (25%)) were published in the period of 2017–2021. Results and discussion: The diversity of plants in the world is a promising ground for therapeutic improvisation, allowing for an individual approach to each patient, but, most importantly, creates possibilities for maneuvering in the event of ineffectiveness of any means. In some situations, herbal medicine is not only possible or permissible, but strictly mandatory, and is essentially the only effective therapeutic method, which is relatively safe provided the correct selection of combinations and control by a doctor who applies a certain method of phytotherapy, especially given a duration of treatment. The need for a deeper study is long overdue for the pharmacological capabilities of various plant raw materials in the treatment of not only this pathology, but others as well. Conclusion: The development of phytotherapy should be based primarily on scientific developments, but this area can not be considered the prerogative of only phytotherapists, as herbal medicines should be in the arsenal of doctors of all specialties.

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“…Previous studies demonstrated that LPS induced βamyloid peptide deposit and inflammation in the neural tissue resulted in severe learning and memory impairment using various behavioural tasks 17,18,19 The systemic inflammation and neuroinflammation induced by LPS injection, which promotes the formation of Aβ plaque and neurofibrillary tangles, are two hallmarks of AD. 12 Both stimulate continuous hyperactivation of microglia and astrocytes that further activates the release of proinflammatory cytokines such as tumour necrosis factor-α (TNF-α), interleukin-1a (IL-1a) and complement protein (C1q).…”

Section: Effects On Level O Expression O Iba-1 and Gfap Proteinsmentioning

confidence: 99%

Minocycline Ameliorated LPS-Induced Learning and Memory Impairment by Inhibiting Microglia and Astrocytes Activation in The Hippocampus

Long

Qaid²,

Abdullah

et al. 2022

imjm

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INTRODUCTION: Many studies support the notion that neuroinflammation involving glial cells may be the fundamental pathogenic event that lead to brain damage and degeneration in Alzheimer’s disease (AD). The effects of minocycline on glial cells activation in the lipopolysaccharide (LPS) rat model is studied here. MATERIALS AND METHODS: Fifty adult male Sprague Dawley rats were split into five groups: control, LPS, LPS-treated with minocycline 25 mg/kg, LPS-treated with minocycline 50 mg/kg, and LPS treated with memantine 10 mg/kg. For two weeks, rats were treated with minocycline and memantine intraperitoneally daily, while were injected with LPS intraperitoneally once on day 5. Morris water maze (MWM) test was performed to evaluate the learning and working memory behaviour. Immunohistochemistry and Western blot were performed to measure ionized calcium-binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) expressions in the hippocampal tissue. RESULTS: LPS injection caused significant learning and working memory deficits (p<0.05) as well as increased expressions of Iba-1 and GFAP (p<0.05), indicating microglia and astrocytes activation, respectively. Minocycline treatment significantly improved learning and working memory performance (p<0.05) and reduced microglia/astrocytes activation (p<0.05) in a dose-dependent manner, similar to the effect of memantine. CONCLUSIONS: Our results suggest that minocycline modulates LPS-induced microglia and astrocytes activation as well as improves learning and working memory comparable to memantine. Thus, minocycline may have preventive-therapeutic effect in diseases involving neuroinflammation such as AD.

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Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties

Abstract:
Levisticum officinale (Apiaceae) has been identified as a medicinal plant in traditional medicine, with the anti-inflammatory, antioxidant, and anticholinesterase activities.

Cited by 22 publications

References 78 publications

Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats

Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Minocycline Ameliorated LPS-Induced Learning and Memory Impairment by Inhibiting Microglia and Astrocytes Activation in The Hippocampus

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Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties

Abstract: Levisticum officinale (Apiaceae) has been identified as a medicinal plant in traditional medicine, with the anti-inflammatory, antioxidant, and anticholinesterase activities.

Cited by 22 publications

References 78 publications

Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats

Supplementation of Carvacrol Attenuates Hippocampal Tumor Necrosis Factor-Alpha Level, Oxidative Stress, and Learning and Memory Dysfunction in Lipopolysaccharide-Exposed Rats

Current view on the problem of treating fibrocystic breast disease in terms of herbal medicine

Minocycline Ameliorated LPS-Induced Learning and Memory Impairment by Inhibiting Microglia and Astrocytes Activation in The Hippocampus

Contact Info

Product

Resources

About

Abstract:
Levisticum officinale (Apiaceae) has been identified as a medicinal plant in traditional medicine, with the anti-inflammatory, antioxidant, and anticholinesterase activities.