Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer’s disease

Abstract

Pharmacological studies have shown that some traditional Chinese medicines (TCMs) have applications in the treatment of Alzheimer’s disease (AD). Morinda officinalis How. (MO) is a TCM with a long history and is widely used to tonify kidney Yang. In vitro and in vivo experiments have suggested that MO contains various effective pharmaceutical components and chemicals, including oligosaccharides, anthraquinones, iridoids, flavonoids, amino acids, and trace elements, conferring MO with anti-inflammatory and antioxidant properties. Neuroinflammation and oxidative stress are undoubtedly hallmarks of neurodegeneration, contributing to AD progression. In this mini-review, we summarize the molecular mechanisms, structure-activity relationships, and potential synergistic and antagonistic effects of active components in MO. This discussion highlights the roles of these active components, such as oligosaccharides, anthraquinones, and iridoid glycosides, in the treatment of AD via anti-inflammatory and antioxidant mechanisms, providing a scientific basis for further utilization of MO.

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

“…The disease can be divided into two categories: deficiency is caused by Yin deficiency and essence deficiency, brain and pulp insufficiency, and the solid is caused by phlegm turbidness, temperament and blood stasis. Tonifying kidney and essence is the basic principle of TCM treatment of AD, which runs through the whole treatment of AD [ 14 ]. The main mechanisms include reducing the production and aggregation of Aβ, inhibiting the phosphorylation of tau protein, inhibiting neuroinflammation, reducing oxidative stress and so on [ 15 ].…”

Improvement of both human and animal memory by synergy between fructooligosaccharide and L‐theanine function establishing a safe and effective food supplement

“…Morinda officinalis has been utilized in both food and medicine for thousands of years. In the context of traditional Chinese medicine, M. officinalis has been reported to delay aging and function as an antidepressant (Zhang & Zhang, 2022 ). The main components utilized in this context from M. officinalis include oligosaccharides, anthraquinones, iridoid glycosides, organic acids, trace elements, amino acids, and sterols (Zhang et al., 2022 ).…”