Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson’s disease

Fathy, Samah M.; El-Dash, Heba A.; Said, Noha I

doi:10.1186/s12906-021-03298-y

Cited by 18 publications

(5 citation statements)

References 64 publications

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“…Recently, Fathy et al [ 32 ] studied the effect of pomegranate seed extract on a paraquat-induced mouse model of Parkinson’s disease. Animals started to receive the extract orally on daily basis for two weeks then continued concomitantly with intraperitoneal injections of paraquat twice daily for three weeks.…”

Section: Discussionmentioning

confidence: 99%

Improved Efficiency of Pomegranate Seed Oil Administrated Nasally

Natsheh

Touítou

2022

Pharmaceutics

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Pomegranate seed oil (PSO) is currently administrated orally as a food supplement for improving memory. However, the efficiency of the oral dosage forms for such purposes is low, mainly due to the blood brain barrier impeding a good delivery to brain. In this work, we designed and characterized a PSO phospholipid oily gel for nasal administration. We tested the performance of the new PSO delivery system in animal models for impaired memory and locomotor activity. The experimental results indicated a statistically significant improvement (p < 0.05) of more than 1.5 fold in the behavior of animals treated nasally, in comparison to those treated with orally administrated oil. Furthermore, in multiphoton microscopy and near infrared imaging studies, the nasal administration of fluorescent probes, fluorescein isothiocyanate (FITC), and indocyanine green (ICG) incorporated in the PSO system showed enhanced delivery to the brain. Results of the histopathologic examination of the nasal cavity and mucosa, as carried out by a pathologist, indicated the safety of the PSO phospholipid oily gel. In conclusion, the results of this work encourage further investigation of the phospholipid oily gel composition as a new way of PSO administration.

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Section: Discussionmentioning

confidence: 99%

Improved Efficiency of Pomegranate Seed Oil Administrated Nasally

Natsheh

Touítou

2022

Pharmaceutics

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“…Treatment of PQ-induced mice with oral administration of PG (seed of juice) led to a significant decrease in MDA levels and a substantial increase in the striatal activities of SOD, GPx, and CAT when compared with the PQ (alone)-treated group. Treatment of PQ-induced mice with PG (seed of juice) significantly decreased the striatal levels of TNF-α, IL-1β, CD11b, TGF-β and significantly increased the levels of IL-10,GDNFwhen compared with PQ (alone)-treated mice 38 .…”

Section: Ginkgo Bilobamentioning

confidence: 95%

Untitled

2023

IJPSR

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Parkinson's disease (PD) is a common neurodegenerative disorder that affects approximately 2% of the population aged over 65. Dopamine precursor L-3,4-dihydroxyphenylalanine (L-DOPA) is the main treatment to provide symptomatic relief for Parkinson's disease (PD). However, with longterm administration of L-DOPA, as many as 95% of patients develop several complications. Medicinal plants (MP) and their active components have been used throughout the worldfor the management and treatment of several diseases such as PD. The World Health Organization (WHO) estimates that 80% of population in developing countries, particularly in Africa, use traditional medicine due to financial constraints. Thus, the use of medicinal plants represents the therapeutic response for populations who have difficulty accessing modern drugs and a source of income. Several MP have been administered over a long period, and they have been proven to cure PD. Therefore, this review provides a summary of recent advance of MPand their bioactive compounds involved in the treatment of PD from the year 2018up to now. INTRODUCTION:Parkinson's disease (PD) is a relentlessly neurodegenerative and progressive disease that is mainly associated with various motor and complications, including resting tremor, rigidity, bradykinesia, postural instability and gait disorder 1, 2 .

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“…[ [131][132][133][134][135][136][137][138][139][140][141][142][143] : the key feature is present; : the key feature is not present.…”

Section: Rotenonementioning

confidence: 99%

Parkinson’s Disease: Exploring Different Animal Model Systems

Khan

Hasan

Haque

2023

IJMS

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Disease modeling in non-human subjects is an essential part of any clinical research. To gain proper understanding of the etiology and pathophysiology of any disease, experimental models are required to replicate the disease process. Due to the huge diversity in pathophysiology and prognosis in different diseases, animal modeling is customized and specific accordingly. As in other neurodegenerative diseases, Parkinson’s disease is a progressive disorder coupled with varying forms of physical and mental disabilities. The pathological hallmarks of Parkinson’s disease are associated with the accumulation of misfolded protein called α-synuclein as Lewy body, and degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc) area affecting the patient’s motor activity. Extensive research has already been conducted regarding animal modeling of Parkinson’s diseases. These include animal systems with induction of Parkinson’s, either pharmacologically or via genetic manipulation. In this review, we will be summarizing and discussing some of the commonly employed Parkinson’s disease animal model systems and their applications and limitations.

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Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson’s disease

Cited by 18 publications

References 64 publications

Improved Efficiency of Pomegranate Seed Oil Administrated Nasally

Improved Efficiency of Pomegranate Seed Oil Administrated Nasally

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Parkinson’s Disease: Exploring Different Animal Model Systems

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