Neuroprotective effects of pre-ischemic exercise are linked to expression of NT-3/NT-4 and TrkB/TrkC in rats

Moghanlou, AbdorrezaEghbal; Yazdanian, Mohtaram; Roshani, Sajad; Demirli, Abdullah; Seydyousefi, Mehdi; Metz, Gerlinde A. S.; Faghfoori, Zeinab

doi:10.1016/j.brainresbull.2023.01.004

Cited by 3 publications

(1 citation statement)

References 56 publications

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“…It has been suggested that the involvement of NT-3 and NT-4 in the etiopathogenesis of degenerative IVD disease and the development and progression of the accompanying pain [36] is related to the signal transduction initiated by the interaction of NT-3 or NT-4 with TrkA, the TrkB receptor, TrkC, or p75NTR [37]. Given these observations, it can be assumed that NT-3 and NT-4 do not directly affect the occurrence of discogenic pain and the development of IVD degenerative disease of the L/S spine; rather, they exert an indirect effect, acting as activators of several signaling pathways and thereby changing the expression profiles of other neurotrophic factors that are more important in the neoinversion process.…”

Section: Discussionmentioning

confidence: 99%

The Impacts of Intervertebral Disc Degeneration of the Spine, Alcohol Consumption, Smoking Tobacco Products, and Glycemic Disorders on the Expression Profiles of Neurotrophins-3 and -4

Staszkiewicz,

Gładysz,

Sobański

et al. 2024

Biomedicines

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In the etiology of discogenic pain, attention is paid to the role of neurotrophic factors, which include classic neurotrophins (NTs). This study aimed to assess changes in the concentrations of NT-3 and NT-4 in the intervertebral discs (IVDs) of the lumbosacral (L/S) spine depending on the advancement of degenerative changes, pain severity, habits, and comorbidities. The study group included 113 patients who underwent microdiscectomy due to degenerative IVD disease of the L/S spine. The severity of degenerative IVD changes was assessed using the five-point Pfirrmann scale, and the pain intensity was assessed according to the visual analog scale (VAS). In turn, the control group included 81 participants from whom IVDs of the L/S section of the spine were collected post-mortem during forensic autopsy or organ donation. At the mRNA level, we noted NT-3 overexpression in the test samples compared with the controls (fold change (FC) = 9.12 ± 0.56; p < 0.05), while NT-4 transcriptional activity was decreased in the test samples compared with the controls (FC = 0.33 ± 0.07; p < 0.05). However, at the protein level, the concentrations of NT-3 (134 ± 5.78 pg/mL vs. 6.78 ± 1.17 pg/mL; p < 0.05) and NT-4 (316.77 ± 8.19 pg/mL vs. 76.92 ± 4.82 pg/mL; p < 0.05) were significantly higher in the test samples compared with the control samples. Nevertheless, the concentration of both proteins did not statistically significantly change depending on the advancement of degenerative changes and the pain intensity (p > 0.05). In addition, higher levels of NT-3 and NT-4 were noted in IVD samples from patients who consumed alcohol, smoked tobacco, were overweight/obese, or had comorbid diabetes compared with patients without these risk factors (p < 0.05). Our analysis confirmed that differences in the degenerative process of IVD, energy metabolism, and lifestyle are related to changes in the concentration profiles of NT-3 and NT-4.

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Section: Discussionmentioning

confidence: 99%

The Impacts of Intervertebral Disc Degeneration of the Spine, Alcohol Consumption, Smoking Tobacco Products, and Glycemic Disorders on the Expression Profiles of Neurotrophins-3 and -4

Staszkiewicz,

Gładysz,

Sobański

et al. 2024

Biomedicines

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Internet + wearable device training effects on limb function recovery and serum neurocytokine content in stroke patients

Wang,

Liu,

Wang

et al. 2024

NRE

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BACKGROUND: The traditional method of post-hospital intervention and guidance of stroke patients has some limitations. OBJECTIVE: To investigate the effects of Internet + wearable device training on limb function recovery and the levels of serum neurocytokines (BDNF, NT-3, and NGF) in stroke patients. METHODS: 80 stroke patients with hemiplegia were randomly selected from the Department of Neurorehabilitation, Affiliated Rehabilitation Hospital of Chongqing Medical University. They were divided into a control group and an observation group, with 40 patients in each group. The control group received routine post-hospital follow-up guidance, while the observation group received Internet remote home rehabilitation guidance combined with wearable device training. The interventions were compared between the two groups. RESULTS: At 4 weeks and 12 weeks after discharge, the observation group showed higher scores on the Fugl-Meyer scale (FMA), Berg Balance Scale (BBS), modified Barthel Index (MBI), stride length, gait speed, gait frequency, and higher levels of BDNF, NT-3, and NGF. Additionally, the observation group had lower scores on the Hamilton Anxiety and Depression Scale (HADS) (P < 0.05). CONCLUSIONS: The application of Internet remote home rehabilitation guidance combined with wearable device training in stroke patients with hemiplegia can improve limb function recovery. It effectively increases the levels of BDNF, NT-3, and NGF, promoting the nutritional repair of damaged nerves. These findings hold clinical significance.

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Research progress of neurotrophic factor 4 in nerve injury repair

2024

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Neurotrophin-4 (NT-4), the fourth member of the nerve growth factor family (NGFs), was found in vipers and African toad in 1991, and it was named for its similar gene sequence structure and biological activity with the first three growth factors of NGFs. Up to now, much evidence has addressed the role of NT-4 in nerve injury and repair. With the study of NT-4 gradually deepening, a certain understanding of its biochemical characteristics and distribution in tissues needs to be clarified. This paper gives a brief review of the biological role of NT-4 and its relationship with nerve injury repair. It gives a preliminary discussion on the role of NT-4 in nerve injury repair.

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Neuroprotective effects of pre-ischemic exercise are linked to expression of NT-3/NT-4 and TrkB/TrkC in rats

Cited by 3 publications

References 56 publications

The Impacts of Intervertebral Disc Degeneration of the Spine, Alcohol Consumption, Smoking Tobacco Products, and Glycemic Disorders on the Expression Profiles of Neurotrophins-3 and -4

The Impacts of Intervertebral Disc Degeneration of the Spine, Alcohol Consumption, Smoking Tobacco Products, and Glycemic Disorders on the Expression Profiles of Neurotrophins-3 and -4

Internet + wearable device training effects on limb function recovery and serum neurocytokine content in stroke patients

Research progress of neurotrophic factor 4 in nerve injury repair

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