Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats

Braun, Josiane Bizzi Schlemmer; Ruchel, Jader Betsch; Adefegha, Stephen A.; Coelho, Ana Paula Visintainer; Trelles, Kelly Bordin; Signor, Cristiane; Rubin, Maribel Antonello; Oliveira, Juliana Sorraila de; Dornelles, Guilherme Lopes; Andrade, Cínthia Melazzo de; Castilhos, Lívia Gelain; Leal, Daniela Bitencourt Rosa

doi:10.1016/j.biopha.2017.01.134

Cited by 22 publications

(11 citation statements)

References 86 publications

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“…Several reports demonstrated that the levels of plasma TC, TG, HDL-C, and LDL-C, which have significance from normal rats, can suggest the establishment of hyperlipidemia [21,[27][28][29]. The experimental results indicated that the plasma CL increased after the combined medication of PAL and HSYA in the hyperlipidemia model and the difference was significant (p < 0.01), which suggests that the 2 drugs influence each other greatly in plasma CL.…”

Section: Discussionmentioning

confidence: 48%

“…It reveals the process in vivo and clarifies the substance effective ingredient of TCM [20]. A large number of studies have shown that DHI exhibits a good effect on clinical hyperlipidemia [5,[21][22][23]. This study investigated the pharmacokinetic analysis of single and combined medication of PAL and HSYA, which are the 2 main parts of DHI.…”

Section: Discussionmentioning

confidence: 99%

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Pharmacokinetic Study on Protocatechuic Aldehyde and Hydroxysafflor Yellow A of Danhong Injection in Rats with Hyperlipidemia

Zhou¹,

Li²,

Jin³

et al. 2018

Pharmacology

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Background: Protocatechuic aldehyde (PAL) and hydroxysafflor yellow A (HSYA) are 2 effective ingredients of Danhong Injection, which is extensively used for the clinical treatment of cardio-cerebrovascular diseases. This study aims to investigate the pharmacokinetic differences between single and combined medication of PAL and HSYA and analyze the interaction of the above effective components in hyperlipidemia rats. Methods: Thirty male SD rats were randomly divided into the control group (n = 6) and the model group (n = 24). The hyperlipidemia model was established by feeding with superfatted forage. The successful model rats were then randomly divided into the PAL group (16 mg/kg), the HSYA group (10 mg/kg), and the combination group (16 mg/kg + 10 mg/kg). Administration through tail-vein, and orbital blood was sampled at different time points. The mass concentration of PAL and HSYA was determined by high performance liquid chromatography (HPLC-DAD). Analysis of pharmacokinetic parameters was conducted by using DAS 3.2.6 software and SPSS 19.0 statistical analysis software. Results: According to the parameters of statistical moment of non-compartmental model, there was a significant difference in plasma clearance (CL) between the PAL group and the drug combination group (p < 0.01), as well as in the area under the first moment of the plasma concentration-time curve and the elimination half-life (t_1/2) between the HSYA group and the drug combination group (p < 0.01) but no obvious differences about the blood concentration time curve area, the average dwell time (MRT), and the peak concentration (C_max; p > 0.05). Conclusion: The combined medication of PAL and HSYA could increase the plasma CL significantly and have a great influence on the absorption of HSYA in rats with hyperlipidemia.

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Section: Discussionmentioning

confidence: 48%

Section: Discussionmentioning

confidence: 99%

Pharmacokinetic Study on Protocatechuic Aldehyde and Hydroxysafflor Yellow A of Danhong Injection in Rats with Hyperlipidemia

Zhou¹,

Li²,

Jin³

et al. 2018

Pharmacology

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“…P407 is a widely used nonionic surfactant that could cause hyperlipidemia and atherosclerosis in rodents [27]. In addition to vascular endothelial dysfunction, P407-induced models show abnormalities in tissues, including the liver [27], heart [35], and hippocampus [36], and a 0.5 g/kg P407 injection in mice for 24 h is enough to induce hyperlipidemia [37]. Therefore, we used one injection of 0.5 g/kg P407 to explore the underlying mechanism of acute hyperlipidemia-induced metabolic disorders and impairment in mice livers and hearts.…”

Section: Discussionmentioning

confidence: 99%

Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade

Cao

Liu

et al. 2020

Nutrients

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Hyperlipidemia is associated with metabolic disorders, but the detailed mechanisms and related interventions remain largely unclear. As a functional food in Asian diets, Herba houttuyniae has been reported to have beneficial effects on health. The present research was to investigate the protective effects of Herba houttuyniae aqueous extract (HAE) on hyperlipidemia-induced liver and heart impairments and its potential mechanisms. Male C57BL/6J mice were administered with 200 or 400 mg/kg/day HAE for 9 days, followed by intraperitoneal injection with 0.5 g/kg poloxamer 407 to induce acute hyperlipidemia. HAE treatment significantly attenuated excessive serum lipids and tissue damage markers, prevented hepatic lipid deposition, improved cardiac remodeling, and ameliorated hepatic and cardiac oxidative stress induced by hyperlipidemia. More importantly, NF-E2 related factor (Nrf2)-mediated antioxidant and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α)-mediated mitochondrial biogenesis pathways as well as mitochondrial complex activities were downregulated in the hyperlipidemic mouse livers and hearts, which may be attributable to the loss of adenosine monophosphate (AMP)-activated protein kinase (AMPK) activity: all of these changes were reversed by HAE supplementation. Our findings link the AMPK/PGC-1α/Nrf2 cascade to hyperlipidemia-induced liver and heart impairments and demonstrate the protective effect of HAE as an AMPK activator in the prevention of hyperlipidemia-related diseases.

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“…Pretreatment with quercetin (5, 25, and 50 mg/kg, p.o., 30 days) has been shown to prevent memory impairment in poloxamer‐407‐induced hyperlipidemic rats, increase the recognition index, and prevent AChE activity from decreasing in the hippocampus. Furthermore, pretreatment with quercetin decreased the total cholesterol and increased HDL cholesterol levels in hyperlipimedic rats (Braun et al., ).…”

Section: Quercetin and Memorymentioning

confidence: 99%

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

Babaei

Mirzababaei

Nassiri‐Asl

2018

Journal of Food Science

103

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Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the research on quercetin and its role in memory in both animals and humans. Articles were chosen from the Scopus, PubMed, and Web of Science databases. In this review, we describe and summarize the importance of quercetin's presence in the body, particularly in the brain; its kinetics, including its absorption, metabolism, distribution, and excretion; its behavioral effects; and some of the possible mechanisms of action of quercetin on memory in different animal models. Several important pathways that may be involved in the processes of learning and memory, long-term potentiation, and cognition may be impaired during neurological diseases or other medical conditions. As dietary quercetin is important, provision of its best formulation for delivery to the brain as a nutraceutical and in clinical translational research for the prevention or treatment of Alzheimer's disease and other types of dementia is necessary.

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Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats

Cited by 22 publications

References 86 publications

Pharmacokinetic Study on Protocatechuic Aldehyde and Hydroxysafflor Yellow A of Danhong Injection in Rats with Hyperlipidemia

Pharmacokinetic Study on Protocatechuic Aldehyde and Hydroxysafflor Yellow A of Danhong Injection in Rats with Hyperlipidemia

Herba houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade

Quercetin in Food: Possible Mechanisms of Its Effect on Memory

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