Neuroprotective effects of quercetin on memory and anxiogenic-like behavior in diabetic rats: Role of ectonucleotidases and acetylcholinesterase activities

Effect of quercetin-conjugated superparamagnetic iron oxide nanoparticles on diabetes-induced learning and memory impairment in rats

“…20 In 2016, Maciel et al also showed that QC administration by gavage (5-50 mg/kg, once daily, 40 days) was able to prevent the impairment of memory induced by STZ-diabetes. 21 of QC on learning and memory that has been observed in the present study could be because of several reasons. 1) QC acts as a direct antioxidant due to the presence of two pharmacophores inside its structure and indirect antioxidant by stimulating cellular defenses against oxidative stress.…”

“…All of the results are consistent with previous studies that diabetes causes memory impairment. 20,21,35 QC, a polyphenol widely present in the human diet, has received the most attention in the CNS due to numerous neurobeneficial activities including free radical scavenging, anti-inflammatory properties, neuroprotection, and cognitive enhancing effects. 36,37 In the present study, treatment with QC by gavage at dose 25 mg/kg once a day for 35 days improved spatial learning and memory retrieval in diabetic rats evidenced by improved performance in the MWM and PAL tests.…”

“…The dose of QC (25 mg/kg, as standard dose) and duration of supplementation (35 days) were selected according to previous reports designating its effectiveness on the improvement of memory. 20,21,[28][29][30][31] All of the treatments were dissolved in DI water and gavaged (08:00-10:00 am) in separate groups of rats. During the experiment, the blood glucose levels were measured seven times: two times before the beginning of treatment, the beginning of treatment, and four times after the treatment at intervals of 10 days.…”

“…19 It has been shown that QC treatment can enhance cognitive impairment in the diabetic rats, which may have the potential for treating neuropathy in diabetic patients. 20,21 In spite of beneficial properties of QC, some in vivo studies have shown that its concentration is very low to pass the blood-brain barrier (BBB) due to poor stability, solubility, distribution, and bioavailability in the brain. 22 Therefore, different QC formulation strategies have been offered to reduce the dose and ameliorate the efficiency of this compound.…”

Quercetin and its role in biological functions: an updated review

“…Here, we summarize the recent studies that have evaluated the biological and pharmacological activities of quercetin (Table 1 (Tab. 1) ; References in Table 1: Abdelhalim et al, 2018[ 1 ]; Afifi et al, 2018[ 2 ]; Aghapour et al, 2018[ 3 ]; Ahmed et al, 2018[ 4 ]; Al-Asmari et al, 2018[ 5 ]; Ansar et al, 2016[ 7 ]; Atef et al, 2017[ 8 ]; Beghoul et al, 2017[ 9 ]; Calgarotto et al, 2018[ 11 ]; Chan et al, 2018[ 12 ]; Chang et al, 2017[ 13 ]; Chen et al, 2017[ 14 ]; Damiano et al, 2018[ 16 ]; Dong et al, 2017[ 17 ]; Duranti et al, 2018[ 18 ]; Esrefoglu et al, 2017[ 20 ]; Funakoshi et al, 2017[ 22 ]; Guo et al, 2017[ 23 ]; He et al, 2016[ 24 ]; Huang et al, 2017[ 25 ]; Jeon et al, 2017[ 26 ]; Ji et al, 2017[ 27 ]; Ju et al, 2018[ 28 ]; Kee et al, 2016[ 29 ]; Lan et al, 2017[ 30 ]; Lazo-Gomez and Tapia, 2017[ 31 ]; Li et al, 2018[ 32 ]; Liu and Zhou, 2017[ 34 ]; Liu et al, 2017[ 35 ]; Lu et al, 2018[ 36 ]; Maciel et al, 2016[ 37 ]; Maksymchuk et al, 2017[ 38 ]; Mitani et al, 2017[ 40 ]; Mkhize et al, 2017[ 41 ]; Naseer et al, 2017[ 42 ]; Pandya et al, 2017[ 45 ]; Patrizio et al, 2018[ 46 ]; Qin et al, 2017[ 47 ]; Ren et al, 2018[ 48 ]; Sameni et al, 2018[ 49 ]; Singh et al, 2018[ 51 ]; Sohn et al, 2018[ 52 ]; Tinay et al, 2017[ 53 ]; Veith et al, 2017[ 54 ]; Wu et al, 2018[ 55 ]; Xingyu et al, 2016[ 56 ]; Yang et al, 2017[ 57 ]; Yang et al, 2018[ 58 ]; Yarahmadi et al, 2017[ 60 ]; Yarahmadi et al, 2018[ 59 ]; Yazıcı et al, 2018[ 61 ]; Yuan et al, 2016[ 63 ]; Yuan et al, 2018[ 62 ]; Zhang et...…”