Neuroprotective Effects of Resveratrol against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress in Rats

Abstract

Alzheimer’s disease is a complex and multifactorial neurodegenerative disease. Central administration of colchicine, a microtubule-disrupting agent, causes loss of cholinergic neurons and cognitive dysfunction that is associated with excessive free radical generation. The present study was aimed at evaluating the effects of trans-resveratrol in the prevention of colchicine-induced cognitive impairment and oxidative stress in rats. Intracerebroventricular administration of colchicine (15 µg/5 µl) induced impaired cognitive functions in both the Morris water maze task and the elevated plus-maze task. Chronic treatment with resveratrol (10 and 20 mg/kg, p.o.) for a period of 25 days, beginning 4 days prior to colchicine injection, significantly improved the colchicine-induced cognitive impairment. Intracerebroventricular colchicine injection resulted in free radical generation characterized by alterations in oxidative stress markers with a significant increase in malondialdehyde (MDA) and nitrite levels and depletion of reduced glutathione (GSH) activity in the rat brains. It also showed a significant decrease in acetylcholinesterase activity. Besides improving cognitive dysfunction, chronic administration of resveratrol significantly reduced the elevated MDA and nitrite levels and restored the depleted GSH and acetylcholinesterase activity. Results of the present study indicated that trans-resveratrol has a neuroprotective role against colchicine-induced cognitive impairment and associated oxidative stress.

Improving effect of chronic resveratrol treatment on central monoamine synthesis and cognition in aged rats

“…Similar protective effects of resveratrol on dopaminergic system has been reported against injuries caused by LPS, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), or 6-hydroxyl dopamine (Rose et al 2014;Blanchet et al 2008;Lofrumento et al 2014;Wang et al 2011). Additionally, some works describe an increased TH expression due to resveratrol treatment, pointing out a SIRT1-mediated effect, which, in turn, could also imply histone deacetylation-mediated effects (Chen et al 2007;Kumar et al 2007;Ranney and Petro 2009;Tredici et al 1999). Thus, SIRT1 activation could be part of the action mechanism for resveratrol pharmacological activities, including a cellular ROS scavenging effect (Araki et al 2004;Li et al 2014).…”

Influence of Polyphenol Extract from Evening Primrose (Oenothera Paradoxa) Seeds on Proliferation of Caco-2 Cells and on Expression, Synthesis and Activity of Matrix Metalloproteinases and Their Inhibitors

“…Polyphenols are plant secondary metabolites widespread in the plant kingdom. They have many benefi cial properties proved in in vitro and in vivo studies, namely: antibacterial [Daglia et al, 2007], antifungal [Báidez et al, 2006], neuroprotective [Kumar et al, 2007] and also anticancer, in particular: antioxidant [Robaszkiewicz et al, 2007], antimetastatic [Ogasawara et al, 2007], proapoptotic [Mertens-Talcott & Percival, 2005], antiproliferative [Letchoumy et al, 2007], antiangiogenic [Lamy et al, 2006], anti-infl ammatory [Clavin et al, 2007]. More precisely, they can infl uence anti-apoptotic proteins (e.g.…”

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

“…Resveratrol, a plant-derived phytoestrogen, may minimise the deterioration in cognitive function associated with physical and chemical damage to the brain [1][2][3][4][5][6][7]. In rats and mice, resveratrol has been found to minimise the adverse brain and cognitive changes induced by neurologically damaging events such as streptozotocin-induced diabetes [1]; percussive cerebral trauma [2]; focal cerebral ischemia (stroke) [3]; oxidative stress caused by intracerebroventricular injection of streptozotocin [4] or cochinine [5]; and neurotoxic substances used to mimic Huntington's disease [6] and Parkinson's disease [7].…”