Neuroprotective effects of salidroside against 6-OHDA-induced oxidative stress in PC12 cells

Li, Minyan; Wang, Sha; Fu, Chaomei; Chen, Hongyu; Su, Yeping; Wu, Po-Liang; Yan, Xinhao; Gao, Juanjuan

doi:10.1039/d3nj01746j

New J. Chem.

2023

DOI: 10.1039/d3nj01746j

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Neuroprotective effects of salidroside against 6-OHDA-induced oxidative stress in PC12 cells

Minyan Li¹,

Sha Wang²,

Chaomei Fu³

et al.

Abstract: Parkinson's disease (PD) is the second-most common neurodegenerative disease characterized by oxidative stress (OS) in the development and progression of PD. This study determined the neuroprotective effects of Salidroside (Sal)....

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2024

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Ameliorating Mitochondrial Dysfunction for the Therapy of Parkinson's Disease

Zheng,

Liu,

Gao

et al. 2024

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Parkinson's disease (PD) is currently the second most incurable central neurodegenerative disease resulting from various pathogenesis. As the “energy factory” of cells, mitochondria play an extremely important role in supporting neuronal signal transmission and other physiological activities. Mitochondrial dysfunction can cause and accelerate the occurrence and progression of PD. How to effectively prevent and suppress mitochondrial disorders is a key strategy for the treatment of PD from the root. Therefore, the emerging mitochondria‐targeted therapy has attracted considerable interest. Herein, the relationship between mitochondrial dysfunction and PD, the causes and results of mitochondrial dysfunction, and major strategies for ameliorating mitochondrial dysfunction to treat PD are systematically reviewed. The study also prospects the main challenges for the treatment of PD.

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Ameliorating Mitochondrial Dysfunction for the Therapy of Parkinson's Disease

Zheng,

Liu,

Gao

et al. 2024

Small

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The role of neuron-like cell lines and primary neuron cell models in unraveling the complexity of neurodegenerative diseases: a comprehensive review

Ghiasvand,

Amirfazli,

Moghimi

et al. 2024

Mol Biol Rep

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Neuroprotective effects of salidroside against 6-OHDA-induced oxidative stress in PC12 cells

Abstract: Parkinson's disease (PD) is the second-most common neurodegenerative disease characterized by oxidative stress (OS) in the development and progression of PD. This study determined the neuroprotective effects of Salidroside (Sal)....

Cited by 2 publications

References 32 publications

Ameliorating Mitochondrial Dysfunction for the Therapy of Parkinson's Disease

Ameliorating Mitochondrial Dysfunction for the Therapy of Parkinson's Disease

The role of neuron-like cell lines and primary neuron cell models in unraveling the complexity of neurodegenerative diseases: a comprehensive review

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