Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer&amp;rsquo;s disease models

Zhang, Bei; Wang, Ying; Li, Hui; Xiong, Ran; Zhao, Zongbo; Chu, Xingkun; Li, Qiongqiong; Sun, Suya; Chen, Shengdi

doi:10.2147/dddt.s99958

Cited by 45 publications

(27 citation statements)

References 32 publications

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“…SDS, a phenylpropanoid glycoside extracted from Rhodiola rosea L , has been shown to be neuroprotective in many studies222324. The present study was intended to demonstrate the effect of SDS on RSC 96 cultured on PLGA film in vitro and further the combinational therapy on nerve regeneration after nerve transection injury in rats.…”

Section: Resultsmentioning

confidence: 98%

“…1A), a phenylpropanoid glycoside extracted from Rhodiola rosea L , a popular plant in traditional medicine in Eastern Europe and Asia, has been reported to have diverse pharmacological properties including antiviral, anticancer, hepatoprotective, antidiabetic and antioxidative effects1718192021. SDS has been shown to be neuroprotective in many studies, which raises the possibility of using SDS as a neuroprotective agent after nerve injuries222324. Sheng QS and et al .…”

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confidence: 99%

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Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo

Liu

Zhu

et al. 2017

Sci Rep

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Salidriside (SDS), a phenylpropanoid glycoside derived from Rhodiola rosea L, has been shown to be neuroprotective in many studies, which may be promising in nerve recovery. In this study, the neuroprotective effects of SDS on engineered nerve constructed by Schwann cells (SCs) and Poly (lactic-co-glycolic acid) (PLGA) were studied in vitro. We further investigated the effect of combinational therapy of SDS and PLGA/SCs based tissue engineering on peripheral nerve regeneration based on the rat model of nerve injury by sciatic transection. The results showed that SDS dramatically enhanced the proliferation and function of SCs. The underlying mechanism may be that SDS affects SCs growth through the modulation of neurotrophic factors (BDNF, GDNF and CNTF). 12 weeks after implantation with a 12 mm gap of sciatic nerve injury, SDS-PLGA/SCs achieved satisfying outcomes of nerve regeneration, as evidenced by morphological and functional improvements upon therapy by SDS, PLGA/SCs or direct suture group assessed by sciatic function index, nerve conduction assay, HE staining and immunohistochemical analysis. Our results demonstrated the significant role of introducing SDS into neural tissue engineering to promote nerve regeneration.

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Section: Resultsmentioning

confidence: 98%

mentioning

confidence: 99%

Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo

Liu

Zhu

et al. 2017

Sci Rep

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“…Following experimental traumatic brain injury in mice, Sal administration produced behavioral improvement and decreased apoptosis via modulation of PI3K/Akt signaling. In Aβ (25-35)-induced SH-SY5Y human neuroblastoma cells, it reduced the oxidative stress via enhancing the activity of antioxidant enzymes, decreased also the level of Bax and increased the B-cell lymphomaextra large [Bcl-X(L)] level [17]. This compound revealed also a neuroprotective effect against hydrogen peroxide-induced apoptosis and markedly attenuated H 2 O 2 -induced cell viability loss and apoptotic cell death in a dose-dependent manner [37].…”

Section: Discussionmentioning

confidence: 99%

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

et al. 2018

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SummaryIntroduction: In recent years, the search for potential neuroprotective properties of salidroside and its ability to influence the activity of nervous system become the subject of intense studies of many research groups. None of these studies, however, include an attempt to determine the effect of salidroside on the course of alcohol tolerancein vivo.Objective: The aim of this study was to investigate the ability of salidroside to inhibit the development of alcohol tolerance in rats, determining whether the effect of its action may occur in a dose-dependent manner, reducing both metabolic and central tolerance without affecting body temperature in control rats.Methods: Male Wistar rats were injected daily with ethanol at a dose of 3 g/kg for 9 consecutive days to produce ethanol tolerance. Salidroside in two doses (4.5 mg/kg and 45 mg/kgb.w.) orvehiculumwas administered orally. On the 1st, 3rd, 5th and 8th day a hypothermic effect of ethanol was measured, while the loss of righting reflex procedure was performed on the 2nd, 4th, 6th and 7th day. On the 9th day rats were treated with salidroside, sacrificed 1 h after ethanol injections and blood was collected for blood-ethanol concentration measurement.Results: Salidroside at a dose of 45 mg/kg inhibited the development of tolerance to hypothermic and sedative effects of ethanol, whereas insignificant elevation of blood-ethanol concentration was observed. The dose of 4.5 mg/kgb.w.had minimal effect, only small inhibition of tolerance to hypothermic action was observed. Salidroside affected neither body mass growth nor body temperature in non-alcoholic (control) rats.Conclusions: Results of the study indicate that salidroside at a dose of 45 mg/kg inhibited the development of tolerance to the hypothermic effect of ethanol. Observed inhibition of tolerance to the sedative effect of ethanol seems to be associated with salidroside influence on the central nervous system. A comprehensive explanation of the abovementioned observations requires further pharmacological and pharmacodynamic studies.

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“…However, ICA pretreatment ameliorated this effect, further confirming that ICA protects against NaN 3induced PC12 cell damage through inhibition of mitochondrial dysfunction caused by glucose metabolism disorder. The PI3K/Akt/GSK-3β signaling pathway plays an important role in the development, survival and function of neurons (Li et al, 2016;Zhang et al, 2016), which is critical for the regulation of mitochondrial function. We hypothesized that ICA improves brain mitochondrial energy metabolism disorder, and its mechanism is related to the PI3K/Akt/ Figure 6 Effect of ICA on the phosphorylation level of Tau in NaN 3 -injured PC12 cells.…”

Section: Discussionmentioning

confidence: 99%

Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway

Zhang

Huang

et al. 2020

PeerJ

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Background Icariin (ICA) is one of the major active flavonoids extracted from the traditional Chinese herb Epimedium brevicornum Maxim and has been shown to have neuroprotective effects. This study was designed to investigate the effect of ICA on sodium azide (NaN3)-induced rat adrenal pheochromocytoma (PC12) cell damage and to further examine the underlying mechanisms. Methods To explore its possible mechanism, we used NaN3 (50 mM)-induced neuronal PC12 cell damage. Cell viability was evaluated by CCK-8 and lactate dehydrogenase (LDH) assays. Mitochondrial membrane potential (MMP) was detected by JC-1. Glucose concentration was assessed by the glucose oxidase method. The role of ICA in the PI3K/Akt/GSK-3β signaling pathway was explored by Western blotting. Results The results indicate that pretreatment with ICA reduced NaN3-induced cell damage and significantly reduced the leakage rate of LDH in PC12 cells. ICA pretreatment increased the MMP and a decrease in glucose concentration indicate increased glucose consumption. Furthermore, the protein levels of p-PI3K (p85), PI3K-110α, p-Ser473-Akt and p-Ser9-GSK-3β were markedly decreased in PC12 cells after NaN3 treatment for 24 h, whereas these effects were reverted after pretreatment with ICA. Tau phosphorylation at the Ser396/404 and Thr217 sites was significantly decreased by pretreatment with ICA. Conclusions These results suggest that ICA protects against NaN3-induced neurotoxicity in PC12 cells by activating the PI3K/Akt/GSK-3β signaling pathway.

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Neuroprotective effects of salidroside through PI3K/Akt pathway activation in Alzheimer’s disease models

Cited by 45 publications

References 32 publications

Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo

Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo

Influence of salidroside, a neuroactive compound of Rhodiola rosea L., on alcohol tolerance development in rats

Icariin protects against sodium azide—induced neurotoxicity by activating the PI3K/Akt/GSK-3β signaling pathway

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