Neuroprotective effects of vitamin E on adult rat motor neurones following facial nerve avulsion

Hoshida, Shigeru; Hatano, Miyako; Furukawa, Mitsuru; Ito, Makoto

doi:10.1080/00016480802210431

Cited by 13 publications

(11 citation statements)

References 19 publications

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“…Many different treatments have been described for the treatment of TPFNP, including aminoguanidine, melatonin, Vitamin E, and N-acetylcystein, due to their antioxidant and anti-inflammatory properties [2,29,30]. Therefore, agents with antioxidant and anti-inflammatory properties may help treat traumatic nerve palsy.…”

Section: Discussionmentioning

confidence: 98%

The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model

Şereflican

Yurttaş

Özyalvaçlı

et al. 2016

American Journal of Otolaryngology

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Section: Discussionmentioning

confidence: 98%

The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model

Şereflican

Yurttaş

Özyalvaçlı

et al. 2016

American Journal of Otolaryngology

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“…As a result, medical supplementations have been attempted in incomplete PNI. As PNR occurs in the first weeks of injury, surgery or medication should be initiated at the earliest possible time (11).…”

Section: █ Discussionmentioning

confidence: 99%

Alpha-tocopherol and cyanocobalamin combination accelerates peripheral nerve healing: an experimental animal study

Albay

Akkalp²

2020

Turkish Neurosurgery

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AIM: To evaluate the functional and histopathological results of alpha-tocopherol (vitamin E) and vitamin B 12 on an experimental rat model of peripheral nerve injury. MATERIAL and METHODS: This research included 32 Wistar Hannover rats. The sciatic nerves of the animals were crushed using an aneurysm clamp. The rats were divided into 4 groups, as group 0 (the controls; no treatment), and groups B 12 , E, and B 12 +E, respectively. The rats were analyzed functionally, using the sciatic functional index (SFI), and histopathologically. RESULTS: In the functional analysis, it was determined that vitamin E was as influential as B 12. Concomitant use of these 2 vitamins was found to be more beneficial. The SFI was significantly higher in the B 12 +E group when compared with that of the B12 group, which indicated that vitamin E improved the healing effects of vitamin B 12. In the histopathological evaluation, vitamin E was not effective in the treatment of axonal degeneration (AxD) or edema/inflammation (EI) by itself. Although vitamin B 12 was effective in the treatment of EI, it was ineffective in the treatment of AxD. However, the combination of these vitamins decreased both AxD and EI, which showed that the additive effects of these vitamins could reverse neurological injury when used together. CONCLUSION: Vitamins B 12 and E were effective in the functional recovery of peripheral nerve injury (PNI). Neither vitamin B 12 nor E was effective in the treatment AxD; however, their combination was effective in the treatment of AxD. The results suggested that vitamin E was effective in the treatment of PNI, especially when combined with vitamin B 12. It is our belief that the combination of these vitamins could be used in the treatment of PNI, especially after future studies have been conducted on humans.

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“…In addition to preventing free-radical reactions, vitamin E can act as a chain-breaking antioxidant that prevents lipid peroxidation [ 84 ]. Five articles addressed the role of vitamin E following PNI, all of which were conducted in a rat model [ 82 , 85 , 86 ] except one mouse study [ 87 ] and one cat study [ 88 ]. Vitamin E administration improved sciatic nerve function, increased the number of functional motor neurons, suppressed cold and mechanical allodynia, and decreased Wallerian degeneration, nerve gliosis, muscle atrophy, blood malondialdehyde levels, and injury-induced 4-hydroxynonenal activity [ 85 , 86 ].…”

Section: Reviewmentioning

confidence: 99%

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

Abushukur¹,

Knackstedt²

2022

Cureus

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Peripheral nerve injury (PNI) can result from trauma, surgical resection, iatrogenic injury, and/or local anesthetic toxicity. Damage to peripheral nerves may result in debilitating weakness, numbness, paresthesia, pain, and/or autonomic instability. As PNI is associated with inflammation and nerve degeneration, means to mitigate this response could result in improved outcomes. Numerous nutrients have been investigated to prevent the negative sequelae of PNI. Alpha-lipoic acid, cytidine diphosphate-choline (CDP Choline), curcumin, melatonin, vitamin B12, and vitamin E have demonstrated notable success in improving recovery following PNI within animal models. While animal studies show ample evidence that various supplements may improve recovery after PNI, similar evidence in human patients is limited. The goal of this review is to analyze supplements that have been used successfully in animal models of PNI to serve as a reference for future studies on human patients. By analyzing supplements that have shown efficacy in animal studies, healthcare providers will have a resource from which to guide decision-making regarding future human studies investigating the role that supplements could play in PNI recovery. Ultimately, establishing a comprehensive understanding of these supplements in human patients following PNI may significantly improve post-surgical outcomes, quality of life, and peripheral nerve regeneration.

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Neuroprotective effects of vitamin E on adult rat motor neurones following facial nerve avulsion

Cited by 13 publications

References 19 publications

The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model

The histopathological and electrophysiological effects of thymoquinone and methylprednisolone in a rabbit traumatic facial nerve paralysis model

Alpha-tocopherol and cyanocobalamin combination accelerates peripheral nerve healing: an experimental animal study

The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature

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