Neuroprotective Efficacy of A Combination of Fish Oil and Bacopa Monnieri Against 3-Nitropropionic Acid Induced Oxidative Stress in Rats

Abstract

NPA (10 mg/kg bw, 14d) were supplemented with FO (2 mL/kg bw), BM (100 mg/kg bw) or combination (FO+BM) for 14 days. RESULTS: Higher degree of protection was discernible among FO+BM rats against NPA induced behavioral alterations. Further, NPA administration resulted in significantly elevated oxidative markers in brain regions (striatum-St, cerebellum-Cb) while robust protection was evident among rats supplemented with FO+BM. Depleted GSH levels in St were restored among all the supplemented groups. The combination also predominantly normalized the activity of antioxidant enzymes in brain regions. Further, significantly depleted dopamine levels in St were partially restored only among FO+BM rats. However, the combination did not offer protection against NPA induced mitochondrial dysfunction. CONCLUSION: The present data clearly suggests that it is possible to enhance the degree of neuroprotection by a combination of FO with phytochemicals (such as BM) and thus provides an improved strategy for the treatment/ management of oxidative stress mediated neurodegenerative conditions.