Neuroprotective Evaluation of Extract of Ginger (Zingiber officinale) Root in Monosodium Glutamate-Induced Toxicity in Defferent Brain Areas Male Albino Rats

Waggas, Abeer M.

doi:10.3923/pjbs.2009.201.212

Cited by 50 publications

(31 citation statements)

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“…Natural pungent compounds from plants have been suggested to play a role in protection via antioxidant, anti-inflammatory, and anti-carcinogenic activities [28,29] . For example, various experimental and clinical studies have shown that capsaicin and piperine isolated from pepper fruits, paradol isolated from Amomum melegueta Roscoe, and allicin isolated from garlic exhibit the most potent neuroprotective and anti-inflammatory effects identified for plant compounds to date [28,30,31] . Thus, 6-shogaol may contribute to a protective action against neuroinflammation in PD, although this remains to be studied further.…”

Section: Discussionmentioning

confidence: 99%

6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation

Park

Kim

et al. 2013

Acta Pharmacol Sin

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Aim: 6-Shogaol [1-(4-hydroxy-methoxyphenyl)-4-decen-one], a pungent compound isolated from ginger, has shown various neurobiological and anti-inflammatory effects. The aim of this study was to examine the effects of 6-shogaol on neuroinflammatory-induced damage of dopaminergic (DA) neurons in Parkinson's disease (PD) models. Methods: Cultured rat mesencephalic cells were treated with 6-shogaol (0.001 and 0.01 μmol/L) for 1 h, then with MPP + (10 µmol/L) for another 23 h. The levels of TNF-α and NO in medium were analyzed spectrophotometrically. C57/BL mice were administered 6-shogaol (10 mg·kg -1 ·d -1 , po) for 3 d, and then MPTP (30 mg/kg, ip) for 5 d. Seven days after the last MPTP injection, behavioral testings were performed. The levels of tyrosine hydroxylase (TH) and macrophage antigen (MAC)-1 were determined with immunohistochemistry. The expression of iNOS and COX-2 was measured using RT PCR. Results: In MPP + -treated rat mesencephalic cultures, 6-shogaol significantly increased the number of TH-IR neurons and suppressed TNF-α and NO levels. In C57/BL mice, treatment with 6-shogaol reversed MPTP-induced changes in motor coordination and bradykinesia. Furthermore, 6-shogaol reversed MPTP-induced reductions in TH-positive cell number in the substantia nigra pars compacta (SNpc) and TH-IR fiber intensity in stratum (ST). Moreover, 6-shogaol significantly inhibited the MPTP-induced microglial activation and increases in the levels of TNF-α, NO, iNOS, and COX-2 in both SNpc and ST. Conclusion: 6-Shogaol exerts neuroprotective effects on DA neurons in in vitro and in vivo PD models.

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Section: Discussionmentioning

confidence: 99%

6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation

Park

Kim

et al. 2013

Acta Pharmacol Sin

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“…This effect is seen due to its action on the 5-HT3 receptor (Ajith et al, 2007;Krim et al, 2013;Waggas, 2009;Sabina et al, 2011;Ahmed et al, 2008).…”

Section: Ginger Anti-nausea Effect Due To Chemotherapymentioning

confidence: 99%

Potential health benefits and scientific review of ginger

Al-Awwadi¹

2017

J. Pharmacognosy Phytother.

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Ginger has been known for its several scientific properties and valued for the last 2500 years in different parts of the globe. Ginger has rich phytochemistry and several health promoting perspectives. In ginger family, Zingiber officinalis is one of most widely used species and it is found in several foods and beverages. Ginger has been used commonly to treat diarrhea, stomach upset, indigestion and nausea. It also has anti-inflammatory and antioxidant properties. Ginger constituents are 80% moisture, 2% protein, 2% fiber, 1% mineral, 0.9% fat, and 12% carbohydrate. The chemistry of ginger is well documented with the respect to the oleoresin and volatile oil. It is concluded that, ginger has potential to treat numerous disorders including cancer due to its anti-inflammatory and anti-oxidant properties. It is also useful in controlling the process of aging. This scientific review favors ginger due to its rich phytochemistry; however, due to some ambiguities, it is recommended to conduct clinical trials of ginger with sound protocol design before claiming its efficacy.

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“…Previous studies also demonstrated that ginger or Zingiber officinale could enhance the level of norepinephrine, epinephrine, dopamine and serotonin contents in cerebral cortex and hippocampus (Waggas, 2009), the areas contributing the important role on working memory (D'Esposito et al, 1999;Smith and Jonides, 1999;Moser and Moser, 1998;Stancampiano et al, 1999). It also enhanced the memory performance induced by cerebral ischemia by decreasing infarct volume in both cortical and subcortical area (Watthanatorn et al, 2011).…”

Section: Discussionmentioning

confidence: 88%

Ginger Supplementation Enhances Working Memory of the Post-Menopause Women

Saenghong¹

2011

American Journal of Applied Sciences

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Problem statement:Cognitive impairment is one important problem in post-menopausal women. Although hormone therapy can improve this condition, it also produces adverse effect. Recent findings showed that this condition could be mitigated by the herb. Ginger or Zingiber officinale Roscoe, a plant in a family of Zingiberaceae, was previously demonstrated the neuroprotection and cognitive enhancing effects. Therefore, this study was set up to determine whether ginger rhizome extract could improve attention and working memory of the postmenopausal women. Approach: Sixty healthy post-menopausal women were randomly assigned to receive either placebo or standardized plant extract at doses of 400 and 800 mg once daily for 3 months. After the assessment of biographic information, they were evaluated the working memory and cognitive function using computerized battery test and the auditory oddball paradigm of event related potential before and after 3-month of intervention. Results: The ginger treated group decreased N100 and P300 latencies but increased N100 and P300 amplitudes in accompany with the enhanced working memory including the power of attention, continuity of attention, speed and quality of memory. Conclusion: Our results suggested that ginger is the potential cognitive enhancer for post-menopausal women. However, further researches are still required.

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Neuroprotective Evaluation of Extract of Ginger (Zingiber officinale) Root in Monosodium Glutamate-Induced Toxicity in Defferent Brain Areas Male Albino Rats

Cited by 50 publications

References 0 publications

6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation

6-Shogaol, an active compound of ginger, protects dopaminergic neurons in Parkinson's disease models via anti-neuroinflammation

Potential health benefits and scientific review of ginger

Ginger Supplementation Enhances Working Memory of the Post-Menopause Women

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