Neuroprotective mechanisms of Asiatic acid

Ding, Liuyun; Liu, Tiantian; Ma, Jing

doi:10.1016/j.heliyon.2023.e15853

Cited by 10 publications

(3 citation statements)

References 71 publications

(74 reference statements)

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“…Health Effects [88,89] Asiatic acid IL-17a, and CCL5. Other described action of bacosides refers to the prevention of the leakage of Creatine Kinase from the respective brain and cardiac tissues.…”

Section: Ref Bioactive Compounds Molecular Structuresmentioning

confidence: 99%

“…[88,89] Asiatic acid Anti-inflammatory, antioxidant, antiinfective, antitumor, antimicrobial, neuroprotective, diuretic, and immunostimulatory[90,91] Aspartic acidAnti-inflammatory, antioxidant, anticancer, antibacterial, and fundamental role in memory[92] β -sitosterol Anti-inflammatory, anticancer, hepatoprotective, antioxidant, cardioprotective, antidiabetic, anti-apoptotic and antihistamineAnti-inflammatory, antioxidant, anti-infective, antitumor, antimicrobial, neuroprotective, diuretic, and immunostimulatory[90,91] Aspartic acid…”

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confidence: 99%

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Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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The aging of the global population has increased the prevalence of neurodegenerative conditions. Bacopa monnieri (BM), an herb with active compounds, such as bacosides A and B, betulinic acid, loliolide, asiatic acid, and quercetin, demonstrates the potential for brain health. Limited research has been conducted on the therapeutic applications of BM in neurodegenerative conditions. This systematic review aims to project BM’s beneficial role in brain disorders. BM has anti-apoptotic and antioxidant actions and can repair damaged neurons, stimulate kinase activity, restore synaptic function, improve nerve transmission, and increase neuroprotection. The included twenty-two clinical trials demonstrated that BM can reduce Nuclear Factor-κB phosphorylation, improve emotional function, cognitive functions, anhedonia, hyperactivity, sleep routine, depression, attention deficit, learning problems, memory retention, impulsivity, and psychiatric problems. Moreover, BM can reduce the levels of pro-inflammatory biomarkers and oxidative stress. Here, we highlight that BM provides notable therapeutic benefits and can serve as a complementary approach for the care of patients with neurodegenerative conditions associated with brain disorders. This review adds to the growing interest in natural products and their potential therapeutic applications by improving our understanding of the mechanisms underlying cognitive function and neurodegeneration and informing the development of new therapeutic strategies for neurodegenerative diseases.

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Section: Ref Bioactive Compounds Molecular Structuresmentioning

confidence: 99%

mentioning

confidence: 99%

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Valotto Neto,

Reverete de Araujo,

Moretti Junior

et al. 2024

Antioxidants

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“…AA has been shown to regulate the expression of cytokines, chemokines, growth factors, enzymes, signaling molecules, adhesion molecules, apoptosis-related proteins, cell cycle proteins, genes, and various receptors. In addition, asiatic acid has also been demonstrated to modulate the activity of several transcription factors and their signaling pathways [26,27]. Due to this complex pharmacological activity, AA appears to be an ideal drug candidate for many diseases.…”

Section: Triterpenes: Biological Effects and Mechanism Of Actionmentioning

confidence: 99%

Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review

Wiciński,

Fajkiel-Madajczyk,

Kurant

et al. 2024

Cancers

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Centella asiatica has been recognized for centuries in Eastern medicine for its pharmacological properties. Due to the increasing prevalence of oncological diseases worldwide, natural substances that could qualify as anticancer therapeutics are becoming increasingly important subjects of research. This review aims to find an innovative use for asiatic acid (AA) in the treatment or support of cancer therapy. It has been demonstrated that AA takes part in inhibiting phosphorylation, inducing cell death, and reducing tumor growth and metastasis by influencing important signaling pathways, such as PI3K, Akt, mTOR, p70S6K, and STAT3, in cancer cells. It is also worth mentioning the high importance of asiatic acid in reducing the expression of markers such as N-cadherin, β-catenin, claudin-1, and vimentin. Some studies have indicated the potential of asiatic acid to induce autophagy in cancer cells through changes in the levels of specific proteins such as LC3 and p62. It can also act as an anti-tumor immunotherapeutic agent, thanks to its inductive effect on Smad7 in combination with naringenin (an Smad3 inhibitor). It seems that asiatic acid may be a potential anticancer drug or form of adjunctive therapy. Further studies should take into account safety and toxicity issues, as well as limitations related to the pharmacokinetics of AA and its low oral bioavailability.

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Evolution of lipid nanoparticles as charioteers of Alzheimer's disease therapeutics

Chakraborty,

Patel,

Padhan

et al. 2024

Applied Materials Today

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Neuroprotective mechanisms of Asiatic acid

Cited by 10 publications

References 71 publications

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Investigating the Neuroprotective and Cognitive-Enhancing Effects of Bacopa monnieri: A Systematic Review Focused on Inflammation, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

Can Asiatic Acid from Centella asiatica Be a Potential Remedy in Cancer Therapy?—A Review

Evolution of lipid nanoparticles as charioteers of Alzheimer's disease therapeutics

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