Neuroprotective potential of biochanin-A and review of the molecular mechanisms involved

Singh, Lovedeep; Kaur, Navneet; Bhatti, Rajbir

doi:10.1007/s11033-023-08397-2

Cited by 9 publications

(3 citation statements)

References 88 publications

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“…The HPLC analysis of the commercial A. membranaceus extract showed the presence of several secondary metabolites such as polyphenolic flavonoids, which have anti-inflammatory and immunomodulatory effects. It has been demonstrated that the most present flavonoids, formonetin, biochanin A, and glycitein, may inhibit mitogen-activated protein kinase activation and pro-inflammatory mediator production in several experimental models of inflammation [ 29 , 30 , 31 ], suggesting their involvement in the anti-inflammatory effects of our commercial A. membranaceus extract. Interestingly, the in vitro beneficial effects of A. membranaceus extract on macrophage functions were confirmed in the zymosan-induced peritonitis model.…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Astragalus membranaceus (Fisch.) Bunge Extract in Controlling Inflammatory Response and Preventing Asthma Features

D’Avino

Cerqua

Ullah

et al. 2023

IJMS

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Astragalus membranaceus (Fisch.) Bunge root is used as herbal medicine for its immunomodulating activities in Chinese medicine. Recently, beneficial properties of A. membranaceus on allergic diseases have been proposed. Here we investigated the role of a commercial extract of A. membranaceus, standardized to 16% polysaccharides, in regulating the immune-inflammatory response in vitro and in vivo and its therapeutic application in asthma. A. membranaceus extract inhibited prostaglandin E2 and leukotriene C4 production in stimulated J774 and peritoneal macrophages, respectively. The extract also reduced interlukin-1β, tumor necrosis factor-α, and nitrite production, affecting inducible nitric oxide synthase expression. In vivo experiments confirmed the anti-inflammatory properties of A. membranaceus, as evident by a reduction in zymosan-induced peritoneal cellular infiltration and pro-inflammatory mediator production. The efficacy of A. membranaceus extract in modulating the immune response was confirmed in a model of allergic airway inflammation. Extracts improve lung function by inhibiting airway hyperresponsiveness, airway remodeling, and fibrosis. Its anti-asthmatic effects were further sustained by inhibition of the sensitization process, as indicated by a reduction of ovalbumin-induced IgE levels and the mounting of a Th2 immune response. In conclusion, our data demonstrate the anti-inflammatory properties of the commercial extract of A. membranaceus and its beneficial effects on asthma feature development.

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Section: Discussionmentioning

confidence: 99%

Beneficial Effects of Astragalus membranaceus (Fisch.) Bunge Extract in Controlling Inflammatory Response and Preventing Asthma Features

D’Avino

Cerqua

Ullah

et al. 2023

IJMS

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“…in nature, particularly in terrestrial plants, and display a wide range of biological activities [41]. This compound was able to inhibit the growth of diatom C. socialis, with an EC50 value of 28.60 µ M (8.13 µ g/mL), whereas the positive control Sea-Nine 211 ® presented an EC50 value of 3.93 µ M (1.11 µ g/mL).…”

Section: Isoflavonesmentioning

confidence: 99%

“…In addition to the evaluation of flavonols 71 and 77-82, and flavones 81 and 91-94 described in Sections 2.2 and 2.3, respectively, Haider and collaborators also tested the antifouling activity of the isoflavone biochanin A (102) against diatoms C. socialis, N. leavissima, and N. parva [32]. Although a commercial stock was used, this compound is found in nature, particularly in terrestrial plants, and display a wide range of biological activities [41]. This compound was able to inhibit the growth of diatom C. socialis, with an EC 50 value of 28.60 µM (8.13 µg/mL), whereas the positive control Sea-Nine 211 ® presented an EC 50 value of 3.93 µM (1.11 µg/mL).…”

Section: Other Flavonoidsmentioning

confidence: 99%

The Role of Natural and Synthetic Flavonoids in the Prevention of Marine Biofouling

Pereira,

Pinto,

Almeida

et al. 2024

Marine Drugs

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Marine biofouling is a major concern for the maritime industry, environment, and human health. Biocides which are currently used in marine coatings to prevent this phenomenon are toxic to the marine environment, and therefore a search for antifoulants with environmentally safe properties is needed. A large number of scientific papers have been published showing natural and synthetic compounds with potential to prevent the attachment of macro- and microfouling marine organisms on submerged surfaces. Flavonoids are a class of compounds which are highly present in nature, including in marine organisms, and have been found in a wide range of biological activities. Some natural and synthetic flavonoids have been evaluated over the last few years for their potential to prevent the settlement and/or the growth of marine organisms on submerged structures, thereby preventing marine biofouling. This review compiles, for the first-time, natural flavonoids as well as their synthetic analogues with attributed antifouling activity against macrofouling and microfouling marine organisms.

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Harnessing Therapeutic Potentials of Biochanin A in Neurological Disorders: Pharmacokinetic and Pharmacodynamic Overview

Kumar,

Angelopoulou,

Pyrgelis

et al. 2024

Chemistry & Biodiversity

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Biochanin A, an isoflavone flavonoid with estrogenic activity, is naturally found in red clover and other legumes. It possesses a wide range of pharmacological properties, including antioxidant, anti‐inflammatory, anti‐apoptotic, neuroprotective, and anticancer effects. In recent years, a growing body of pre‐clinical research has focused on exploring the therapeutic potential of biochanin A in various neurological disorders, such as Alzheimer's and Parkinson's disease, multiple sclerosis, epilepsy, ischemic brain injury, gliomas, and neurotoxicity. This comprehensive review aims to shed light on the underlying molecular mechanisms that contribute to the neuroprotective role of biochanin A based on previous pre‐clinical studies. Furthermore, it provides a detailed overview of the protective effects of biochanin A in diverse neurological disorders. The review also addresses the limitations associated with biochanin A administration and discusses different approaches employed to overcome these challenges. Finally, it highlights the future opportunities for translating biochanin A from pre‐clinical research to clinical studies while also considering its commercial viability as a dietary supplement or a potential treatment for various diseases.

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Neuroprotective potential of biochanin-A and review of the molecular mechanisms involved

Cited by 9 publications

References 88 publications

Beneficial Effects of Astragalus membranaceus (Fisch.) Bunge Extract in Controlling Inflammatory Response and Preventing Asthma Features

Beneficial Effects of Astragalus membranaceus (Fisch.) Bunge Extract in Controlling Inflammatory Response and Preventing Asthma Features

The Role of Natural and Synthetic Flavonoids in the Prevention of Marine Biofouling

Harnessing Therapeutic Potentials of Biochanin A in Neurological Disorders: Pharmacokinetic and Pharmacodynamic Overview

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