Neuroprotective Potential of GDF11: Myth or Reality?

Rochette, Luc; Malka, G.

doi:10.3390/ijms20143563

Cited by 17 publications

(7 citation statements)

References 33 publications

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“…(2) The GDF11 enhanced by LIPUS did not show any function on the brain aging. However, it was contradicting with previous reports [43,44]. The relationship between the effect of GDF11 and aging process awaits further investigation.…”

Section: Discussioncontrasting

confidence: 64%

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Wang¹,

Li²,

Xia³

et al. 2021

Gerontology

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Introduction: The low-intensity pulsed ultrasound (LIPUS) is one of the popular treatment modalities allowing to boost the proliferation, differentiation, and migratory activity of cells, which might be a powerful strategy for anti-aging. Seeking a novel setup for LIPUS would benefit the development of ultrasound therapeutics. Methods: Here, we proposed a novel underwater exposure setup of LIPUS. C57BL/6 mice were reared in the designated age-groups, which consisted of a middle-aged group (12–14 months) and an old-age group (20–23 months). The age-related changes of body composition, imbalance of energy supply and demand, imbalance of signal network maintaining internal stability, and representative phenotypes of neurodegeneration and neuroplasticity with the presence and absence of underwater LIPUS in middle-aged and aged groups were evaluated. Results: The results showed that there were obvious aging changes, imbalance of energy supply and demand, imbalance of signal network maintaining homeostasis, neurodegeneration, and damage of neural plasticity in the middle-aged and aged group with or without the LIPUS. Although middle-aged group and aged group responded differently to LIPUS, they mostly generated positive results in relieving bone loss, improving ovarian structure, regulated immune system, and enhanced endurance ability, which should have declined over age. Discussion: These findings indicate that underwater extracorporeal LIPUS exposure could be employed as single or combined anti-aging strategies that generated positive outcomes against the process of aging.

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Section: Discussioncontrasting

confidence: 64%

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Wang¹,

Li²,

Xia³

et al. 2021

Gerontology

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“…It is widely expressed in adult CNS and has a crucial impact on brain development (11). Previous study has shown that GDF-11 can enhance neurogenesis in the brain, especially in the hippocampus, helping remodeling the synapses and repairing the injured neurons (15,29,30). It can also regulate the function of astrocytes, whose activation are shown to contribute to the pathogenesis of schizophrenia (11).…”

Section: Discussionmentioning

confidence: 99%

Decreased Plasma Levels of Growth Differentiation Factor 11 in Patients With Schizophrenia: Correlation With Psychopathology and Cognition

et al. 2020

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Schizophrenia is linked with abnormal neurodevelopment, on which growth differentiation factor 11 (GDF-11) has a great impact. However, a direct evidence linking GDF-11 to the pathophysiology of schizophrenia is still lacking. The current study aimed to investigate the relationship between plasma GDF-11 levels and both psychopathological symptoms and cognitive function in schizophrenia. Eighty-seven schizophrenia patients and 76 healthy controls were enrolled in the present study. The symptomatology of schizophrenia was evaluated using the Positive and Negative Syndrome Scale (PANSS). Cognitive function was assessed by Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) including twelve neurocognitive tests in five aspects of cognitive function. Plasma GDF-11 levels were determined by enzyme-linked immunosorbent assay (ELISA). We found that plasma levels of GDF-11 were significantly lower in schizophrenia patients relative to healthy controls. Correlation analysis showed significant negative correlations between the GDF-11 levels and the PANSS total score, the positive symptoms score, the negative symptoms score or the general score. Additionally, positive associations were observed between plasma GDF-11 levels and the visuospatial/constructional, attention, immediate memory, or delayed memory in patients. Partial correlation analysis showed that these correlations were still significant after adjusting for age, gender, education years, body mass index, duration of illness, and age of onset except for the visuospatial/constructional and attention index. Multiple regression analysis revealed that GDF-11 was an independent contributor to the immediate memory, delayed memory and RBANS total score in patients. Collectively, the correlations between plasma GDF-11 and psychopathological and cognitive symptoms suggest that abnormal GDF-11 signaling might contribute to schizophrenic psychopathology and cognitive impairments and GDF-11 could be a potential and promising biomarker for schizophrenia.

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“…Because GDF11 is highly expressed in the brain and potentially neuroprotective [7], we used The Cancer Genome Atlas (TCGA) to assess the effect of GDF11 expression in malignant gliomas.…”

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

Increased GDF11 expression associated with increased survival of Grade 3 Gliomas

Lehrer

Rheinstein

2022

Preprint

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Background: Infusing young mouse blood into old mice makes the old mice biologically younger. When an old mouse and a young mouse share a circulatory system, the old mouse's muscle function is improved, and the production of olfactory neurons is increased. GDF11 seems to be a crucial element of the young blood in both instances. Methods: Because of GDF11 potential neuroprotective actions, we used The Cancer Genome Atlas (TCGA) to assess the effect of GDF11 expression in malignant gliomas. We analyzed the GDC TCGA lower grade glioma data set. To access TCGA data we used the Xena platform and cBioportal. Statistical analysis was done with SPSS v26. Results: increased GDF11 expression in IDH1 mutant subjects was significant. There was significantly increased survival (p = 0.00065, log rank test) with high GDF11 expression in grade 3 gliomas. The survival effect was less prominent in grade 2 gliomas. GDF11 gene expression was highest in anaplastic oligodendrogliomas and mixed gliomas with 1p 19q co-deletions and few or no TP53 or ATRX mutations. GDF11 gene expression was lowest in anaplastic astrocytomas with no 1p 19q co-deletions and many TP53 and ATRX mutations. Conclusion: GDF11 or an analogue might be therapeutic in grade 3 glioma. GDF11 does not cross the blood brain barrier but affects the brain by acting on brain endothelial cells. GDF11 might be delivered to a brain tumor intranasally.

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Neuroprotective Potential of GDF11: Myth or Reality?

Cited by 17 publications

References 33 publications

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Potential Application of Low-Intensity Pulsed Ultrasound in Delaying Aging for Mice

Decreased Plasma Levels of Growth Differentiation Factor 11 in Patients With Schizophrenia: Correlation With Psychopathology and Cognition

Increased GDF11 expression associated with increased survival of Grade 3 Gliomas

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