Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain

Alivirdiloo, Vahid; Hajiabbasi, Mobasher; Gargari, Morad Kohandel; Gargari, Homa Kohandel; Ghazi, Farhood; Mohammadi, Mahya; Rahimi, Fatemeh; Mobed, Ahmad; mehra, Amin

doi:10.1007/s00044-024-03237-9

Med Chem Res

2024

DOI: 10.1007/s00044-024-03237-9

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Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain

Vahid Alivirdiloo,

Mobasher Hajiabbasi,

Morad Kohandel Gargari

et al.

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2024

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Cited by 2 publications

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Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Chib,

Dutta,

Chalotra

et al. 2024

Phytotherapy Research

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With the passage of time, people step toward old age and become more prone to several diseases associated with the age. One such is Alzheimer's disease (AD) which results into neuronal damage and dementia with the progression of age. The existing therapeutics has been hindered by various enkindles like less eminent between remote populations, affordability issues and toxicity profiles. Moreover, lack of suitable therapeutic option further worsens the quality of life in older population. Developing an efficient therapeutic intervention to cure AD is still a challenge for medical fraternity. Recently, alternative approaches attain the attention of researchers to focus on plant‐based therapy in mitigating AD. In this context, flavonoids gained centrality as a feasible treatment in modifying various neurological deficits. This review mainly focuses on the pathological facets and economic burden of AD. Furthermore, we have explored the possible mechanism of flavonoids with the preclinical and clinical aspects for curing AD. Flavonoids being potential therapeutic, target the pathogenic factors of AD such as oxidative stress, inflammation, metal toxicity, Aβ accumulation, modulate neurotransmission and insulin signaling. In this review, we emphasized on potential neuroprotective effects of flavonoids in AD pathology, with focus on both experimental and clinical findings. While preclinical studies suggest promising therapeutic benefits, clinical data remains limited and inconclusive. Thus, further high‐quality clinical trials are necessary to validate the efficacy of flavonoids in AD. The study aim is to promote the plant‐based therapies and encourage people to add flavonoids to regular diet to avail the beneficial effects in preventive therapy for AD.

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Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Chib,

Dutta,

Chalotra

et al. 2024

Phytotherapy Research

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A Study of the Impact of Magnesium Supplements on Asthma Control

Sharifpour,

Mahmoudi,

Saffarfar

et al. 2024

International Journal of Innovative Science and Research Techno

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Background: In the recent studies, the relationship between the magnesium and asthma has been more considered; hence, the present research has aimed to study this issue.  Methodology: The study is a Randomized double blind placebo control trial, which has been conducted on the asthmatic patients who have been divided into two groups: group one consisting of those who have taken placebo and group two including those who have taken magnesium supplement. In the beginning and during the weeks 4, 8 and 12, FVC, FEV1, FEV1/FVC and ACT score have been measured.  Results: 40 patients have been studied in two equal groups. The improvement rate of FEV1/FVC has been gradually increased in group2 and was significantly higher than group1 in the week 12. It was also higher in week 4 but not significantly. Moreover, according to FVC ratio, in weeks 4 and 12, the cure rate of the group2 was not significantly higher; however, it was significantly higher in the 8th week. The ACT score of group2 has also significantly increased in comparison to it in 4 weeks before the beginning of the study.  Conclusion: It seems that the magnesium supplement is helpful in improving the clinical and spirometric measurements of asthmatic patients.

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Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain

Cited by 2 publications

References 58 publications

Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

Role of Flavonoids in Mitigating the Pathological Complexities and Treatment Hurdles in Alzheimer's Disease

A Study of the Impact of Magnesium Supplements on Asthma Control

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