Neuroprotector Effect Of Strength Training In An Neuroinflammation Animal Model

Abstract

Background: The preventive role of muscular strength in the diminishing of a neuroinflammation is yet unknown. In this study, the role of the prophylactic muscular strength exercise was investigated, whether it would diminish cognitive alterations and modify the antioxidant intracellular scenery in an animal neuroinflammation model of the CA1 region of the hippocampus. Methods: The animals received muscular strength training for eight weeks, three times a week. Subsequently, the stereotaxic surgery, with intra-hippocampal infusion of either saline solution or l ipopolysaccharide (LPS) was performed. Next, behavioral tests were performed: objects and social recognition. At last, the animals were euthanized and the collect of the hippocampus and the prefrontal cortex were performed and, later, the dosage of the antioxidant activity was performed. Results: The results showed that the muscular strength exercises was capable of showing a beneficial prophylactic effect in the oxidative stress caused by an acute neuroinflammation. There was diminishing of the reduced glutathione concentration (GSH) and increase of the activity of the catalase enzyme (CAT) in the group (SE + LPS), regarding the control groups. In the prefrontal cortex, there was only an increase of the CAT activity in the group (SE + LPS), regarding the groups (CT) and (SE + SAL). As for the cognitive alterations there were found in the (SE + LPS) group, diminishing the mnemonic hazard of the discriminative and social memories, when compared to the control groups. Conclusion: We concluded, therefore, that the induction of a local inflammatory process in the hippocampus leads to mnemonic deficits in behavioral activities and increase of the GSH concentration, and that the muscular strength exercise performed prophylactically presents a protective effect capable of minimizing such mnemonic deficits and increasing the antioxidant defenses in mice that suffered a local neuroinflammatory process in the hippocampus.