Neuropsychiatric Disease‐Associated Genetic Variation in the Wnt Pathway

Activation of WNT and CREB signaling pathways in human neuronal cells in response to the Omega-3 fatty acid docosahexaenoic acid (DHA)

“…Our study provides potential insight into the molecular and cellular mechanisms of DHA's antidepressant effect, and provides evidence supporting the stress-neuroplasticity hypothesis of MDD. In particular, our studies demonstrate DHA's effect on the canonical WNT/βcatenin pathway, an essential pathway involved in cell fate, cell proliferation, and cell migration that has been implicated in diverse aspects of the pathophysiology of many neuropsychiatric disorders [51][52][53][54]. Additionally, we demonstrate that DHA modulates CREB (cAMP response element-binding protein)-mediated transcription, which also plays an essential roles in numerous neuronal biological processes, including cell survival, synaptic structure, and synaptic plasticity [55].…”