Neuropsychiatric effects of tenofovir in comparison with other antiretroviral drugs

Ferrer, Kathleen; Rakhmanina, Natella

doi:10.2147/nbhiv.s24888

Cited by 2 publications

(1 citation statement)

References 74 publications

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“…Tenofovir and lamivudine treated groups produced significant distortion of the cortical histomorphology. These results are in tandem with Ferrer and Rakhmanina (2013) who reported peripheral neuropathy in mice treated with tenofovir and the study of Peter et al (2017) who reported shrunken Purkinje cells and distorted granular layer in the cerebellum of rats treated with lamivudine. Several studies highlighting the detrimental effects that antiretroviral drugs have on neural structures are often through mechanisms involving oxidative stress.…”

Section: Discussionsupporting

confidence: 85%

Neurocognitive and Neuroarchitectural Changes in the Prefrontal Cortex of Wistar Rats Treated with Highly Active Antiretroviral Therapy

Dosumu¹,

Akang²,

Edem³

et al. 2021

Nig J Neurosci

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The use of highly active antiretroviral therapy has proven to be highly effective in the treatment of human immunodeficiency virus 1 (HIV-1) infection. However, its impact on cognition has not been fully explored. This study was designed to assess the impacts of antiretroviral therapy on cognitive function and histoarchitecture of the prefrontal cortex of Wistar rats. Forty adult male Wistar rats weighing 180-200 g were randomly assigned to 4 groups: control, tenofovir, lamivudine and efavirenz (n=10), which received 1 ml distilled water and 6 mg/kg, 6 mg/kg and 12 mg/kg, respectively. Spatial memory scores were assessed using the Y-maze test. Following behavioural studies, the animals were euthanized, and their whole brains harvested. The prefrontal cortex was sectioned and processed for oxidative stress, histological and immunohistochemical analyses. There was a significant decrease in percentage alternation evaluated from the right/wrong decisions scored from the tenofovir and lamivudine groups, compared to the control group (p<0.05). malondialdehyde (MDA) and reduced glutathione (GSH) levels were elevated following lamivudine and tenofovir exposure in the rats’ prefrontal cortices, respectively, compared to control (p<0.05). There were also significant alterations of cortical pyramidal cells in the tenofovir and lamivudine groups. Additionally, marked astrogliosis with increased glial fibrillary acidic protein expression was observed, consistent with the structural alterations, especially in the lamivudine group. Our findings suggest that, of the three highly active antiretroviral therapy (HAART) drugs studied, lamivudine may be a major culprit in the progressive neurological damage and cognitive impairment in HIV-infected individuals on HAART.

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Section: Discussionsupporting

confidence: 85%

Neurocognitive and Neuroarchitectural Changes in the Prefrontal Cortex of Wistar Rats Treated with Highly Active Antiretroviral Therapy

Dosumu¹,

Akang²,

Edem³

et al. 2021

Nig J Neurosci

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People living with HIV/AIDS’s experiences receiving antiretroviral therapy: a phenomenological study

Huzaimah

Pratiwi

2020

JIKA

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Antiretroviral (ARV) telah diketahui menimbulkan berbagai efek samping yang menimbulkan ketidaknyamanan baik dimensi fisik maupun psikososial pada orang dengan HIV/AIDS (ODHA). Penelitian ini bertujuan untuk menggali dan mengungkap pengalaman ODHA yang sedang menjalani terapi ARV (ART) di Kabupaten Sumenep. Desain penelitian ini adalah penelitian kualitatif dengan pendekatan fenomenologis. Teknik pengumpulan data menggunakan wawancara dan observasi. Wawancara dilakukan pada partisipan ODHA (n= 11), penanggung jawab HIV di Puskesmas dan Dinas Kesehatan Masyarakat. Transkrip hasil wawancara dan observasi dianalisis secara tematik. Hasil dari penelitian ini didapatkan 7 tema yang menggambarkan pengalaman ODHA yang menjalani ART, yaitu pemahaman tentang HIV/AIDS selama menjalani ART, perasaan saat mengetahui positif HIV, pengalaman stigmatisasi dan diskriminasi, pendukung utama dalam menjalani ART, pengalaman sebelum memulai ART, pengalaman setelah menjalani ART, dan upaya mengurangi efek samping obat. Kesimpulan dari penelitian ini adalah pengalaman ODHA yang mengikuti ART diungkapkan dalam berbagai cerita berdasarkan sudut pandang yang melatarbelakangi. Pengalaman masing-masing individu berisi suatu informasi, ungkapan perasaan, dan harapan yang perlu menjadi fokus perhatian tenaga kesehatan dalam mendampingi dan memberikan asuhan pada ODHA yang menjalani ART. Saran untuk penelitian selanjutnya adalah dilakukan penelitian kuantitatif dengan menggunakan instrumen yang lebih terukur tentang pengetahuan ODHA, infeksi oportunistik, keparahan efek samping ART, jumlah CD4, jumlah virus, dan kesejahteraan psikologis, sosial, dan spiritual terkait dengan ODHA yang menerima ARV.

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Neuropsychiatric effects of tenofovir in comparison with other antiretroviral drugs

Cited by 2 publications

References 74 publications

Neurocognitive and Neuroarchitectural Changes in the Prefrontal Cortex of Wistar Rats Treated with Highly Active Antiretroviral Therapy

Neurocognitive and Neuroarchitectural Changes in the Prefrontal Cortex of Wistar Rats Treated with Highly Active Antiretroviral Therapy

People living with HIV/AIDS’s experiences receiving antiretroviral therapy: a phenomenological study

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