Neuropsychiatric feature profiles of patients with Lewy body dementia

Oliveira, Fabricio Ferreira de; Machado, FR; Sampaio, Gustavo; Marin, Sheilla de Medeiros Correia; Naffah-Mazzacoratti, Maria da Graça; Bertolucci, Paulo Henrique Ferreira

doi:10.1016/j.clineuro.2020.105832

Cited by 29 publications

(27 citation statements)

References 39 publications

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“…Multiple regression analyses also revealed that the "psychosis" factor was also associated with the total score in ZBI, and that the "affection" factor was independently associated with the total and PS scores in ZBI. A previous study examining the relationship between caregiver burden and symptoms in Lewy body dementia reported that IADL and non-motor symptoms were related to caregiver burden in DLB, whereas motor symptoms and IADL were related to caregiver burden in Parkinson's disease dementia (28). The previous and the present results are consistent in suggesting that non-motor symptoms, including BPSD, have a greater impact on the caregiver burden in DLB than motor symptoms.…”

Section: Discussionsupporting

confidence: 84%

Impact of Behavioral and Psychological Symptoms on Caregiver Burden in Patients With Dementia With Lewy Bodies

et al. 2021

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Background/Objective: Behavioral and psychological symptoms of dementia (BPSD) have been reported to affect caregiver burden in patients with dementia with Lewy bodies (DLB). However, the factor structure of BPSD and the factors that affect caregiver burden in DLB remain unknown. This study sought to classify BPSD and to reveal what type of BPSD affects caregiver burden in patients with DLB.Methods: We collected data on neuropsychiatric inventory-plus (NPI-plus), Zarit Burden Interview (ZBI), Mini-Mental State Examination (MMSE), Lawton's Instrumental Activities of Daily Living and Physical Self-Maintenance Scale (IADL/PSMS), age, and sex of 102 patients with probable DLB. An exploratory factor analysis of 13 items of the NPI-plus was carried out to classify BPSD. Multivariate regression analyses were conducted to extract the clinical variables related to caregiver burden, including factors resulting from the aforementioned factor analysis.Results: The mean age and MMSE score were 78.6 (5.6) and 20.2 (5.2), respectively. Factor analysis revealed four factors of “psychosis,” “affection,” “wakefulness,” and “hyperactivity.” “Psychosis” and “affection” factors as well as MMSE, IADL, and PSMS were significantly associated with ZBI. Multivariate regression analyses revealed that the total score of ZBI was associated with “psychosis,” “affection,” and IADL, that the personal strain score of ZBI was associated with “affection” and IADL, and that the role strain score of ZBI was associated with “wakefulness” and IADL.Conclusions: BPSD in DLB consists of three factors common to Alzheimer's disease and a specific “wakefulness” factor. In addition to IADL, each BPSD factor would affect caregiver burden in different ways in DLB.

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Section: Discussionsupporting

confidence: 84%

Impact of Behavioral and Psychological Symptoms on Caregiver Burden in Patients With Dementia With Lewy Bodies

et al. 2021

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“…Future revisions could consider research findings and features described by investigators in other parts of the world. 49,50 The LBD- Findings from this study will be helpful in providing the initial evidence base for the use of the LBD-MOD in clinical research. The LBD-MOD appears to provide sufficient clinical discrimination between DLB and AD so that it can aid in diverse clinical research programs such as case-ascertainment in epidemiological studies, biomarker studies, cross-sectional and longitudinal studies, and clinicopathological correlation.…”

Section: Discussionmentioning

confidence: 93%

“…The LBD‐MOD was created by dementia and movement disorder experts from the United States. Future revisions could consider research findings and features described by investigators in other parts of the world 49,50 . The LBD‐MOD was validated in the context of an academic research setting where the prevalence of MCI and dementia in general, and DLB in particular, are high, and the participants tend to be highly educated and predominantly White.…”

Section: Discussionmentioning

confidence: 99%

Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD)

Galvin

Chrisphonte

Cohen

et al. 2021

Alzheimer's & Dementia

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“…Other possible explanations included the significantly higher risk of fall and ADL dependency in the LBD group (47.5 vs. 31.4%, p < 0.001). Past literature found that the caregiver burden was more affected by depression and motor features in the LBD group, but not by cognitive decline (de Oliveira et al, 2020). Independent ADL function has been reported to be a risk factor associated with the burden of care (Hashimoto et al, 2017;Kawano et al, 2020;Tsai et al, 2021).…”

Section: Discussionmentioning

confidence: 93%

A Comparison of Caregiver Burden for Different Types of Dementia: An 18-Month Retrospective Cohort Study

et al. 2022

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BackgroundThis study aimed to elucidate the influence of dementia etiologies on the degree of caregiver burden and determine which factors predict a high caregiving burden.MethodsThis 18-month retrospective cohort study enrolled 630 patients and their caregivers from the Dementia Center of Changhua Christian Hospital. The care team performed face-to-face interviews every 6 months, for 18 months from when a diagnosis of dementia was made. The primary outcome was the change in Zarit Burden Interview (ZBI) scores. Generalized estimating equations were used for the longitudinal data analysis.ResultsParticipants with Lewy body disease (LBD) had a significantly higher caregiving burden compared with those with Alzheimer's disease (AD) (β = 3.83 ± 1.47, Wald = 6.79, p = 0.009) after adjusting for patient and caregiver features. Caregivers of mixed-type dementia and frontotemporal dementia (FTD) experienced a greater burden than caregivers of AD, at 6- and 18-month follow-up. Patients with more severe dementia, neuropsychiatric symptoms, being cared for by more than two caregivers, or utilizing social resources were associated with higher ZBI scores; the depressive mood of caregiver also predicted higher ZBI scores.ConclusionThis longitudinal study demonstrated that caregiver burden was influenced by the underlying dementia etiology of patients. The dementia care team should provide personalized education and transfer patients and caregivers to appropriate resources, especially for high-risk populations.

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Neuropsychiatric feature profiles of patients with Lewy body dementia

Cited by 29 publications

References 39 publications

Impact of Behavioral and Psychological Symptoms on Caregiver Burden in Patients With Dementia With Lewy Bodies

Impact of Behavioral and Psychological Symptoms on Caregiver Burden in Patients With Dementia With Lewy Bodies

Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD)

A Comparison of Caregiver Burden for Different Types of Dementia: An 18-Month Retrospective Cohort Study

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