Neuropsychiatric Manifestations of Thyroid Disease

Feldman, Andrew B.; Shrestha, Rupendra T.; Hennessey, James V.

doi:10.1016/j.ecl.2013.05.005

Cited by 78 publications

(68 citation statements)

References 133 publications

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“…Thyroid hormones are crucial for the development and normal functioning of the brain [3]. Previous studies have revealed the association of fluctuations in the levels of thyroid hormones with various psychiatric disease manifestations and response to treatment [4]. A recent study has reported an increase in plasma thyroid hormone levels, and reduction in TSH levels in patients with schizophrenia [5].…”

Section: Introductionmentioning

confidence: 98%

Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia

Jose

Nandeesha

Kattimani

et al. 2015

Clinica Chimica Acta

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Section: Introductionmentioning

confidence: 98%

Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia

Jose

Nandeesha

Kattimani

et al. 2015

Clinica Chimica Acta

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“…Subclinical hypothyroidism prevalence in this study was 6.5% which is bit more than the findings of Sham et al, 2014 but in concordance with studies carried out in other part of the globe. 9,10,23,24 Overt hypothyroidism was as per the findings from earlier studies with a prevalence rate of 3.2%. 9,10,23,24 The prevalence of both overt and subclinical hyperthyroidism was lower than those observed by previous studies.…”

Section: Discussionmentioning

confidence: 92%

“…9,10,23,24 Overt hypothyroidism was as per the findings from earlier studies with a prevalence rate of 3.2%. 9,10,23,24 The prevalence of both overt and subclinical hyperthyroidism was lower than those observed by previous studies. 25,26 These variations in our results might be due to the fact that most of those studies were based only on serum TSH level, whereas our interpretation was more accurate, based on TSH, T3, T4 and free T4 level estimation.…”

Section: Discussionmentioning

confidence: 92%

“…8 Overt thyroid disease is rare in depression, 1 to 4% found to be hypothyroid, while subclinical hypothyroidism occurs in 4% to 40% of these patients. 9,10 The most common abnormalities include features of subclinical or overt hypothyroidism, with associated lower levels of thyroxine 11 , and elevated levels of TSH. 12,13 The link between hyperthyroidism and depression is poorly understood.…”

Section: Introductionmentioning

confidence: 99%

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Thyroid profile in depression: a cross-sectional study from North-East India

et al. 2017

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Background: Thyroid function disorder is a common feature in depression, with mixed type of response. Some cases are associated with hyperthyroidism and most commonly hypothyroidism. Unipolar and bipolar depressions are also related differently in consideration to thyroid status. This study comprises of assessment of the thyroid disorder prevalence in depressive patients and comparative analysis among unipolar and bipolar groups.Methods: Study consisted of 161 unipolar and 160 bipolar cases of depression as diagnosed by ICD 10 criteria supported by MINI. Thyroid profiling was done against common thyroid hormones TSH, T3, T4 and FT4 by standard method.Results: Gender wise males were dominant with majority in bipolar group in the younger age group. Most of the cases were normal with few hyperthyroid and hypothyroid cases. Bipolar group comprised the majority of overt hyperthyroid, overt hypothyroid and subclinical hyperthyroid cases, whereas unipolars were more in the subclinical hypothyroid category.Conclusions: This study concludes that differences exist in the thyroid response among the unipolar and bipolar depression group, more prominent numbers of hypothyroidism in unipolar group.

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“…The somatic symptoms include weight loss, tachycardia, excessive sweating, increased appetite, tremor and changes in bowel patterns (4). Two third of patients with thyroid disease have been reported to have psychological symptoms (5,6). Hyperthyroidism has been associated with anxiety, depression, irritability, insomnia and low concentration in several studies (7,8).…”

Section: Introductionmentioning

confidence: 99%

Dose the Clinical Characteristics of Patients with Anxiety due to Hyperthyroidism Differ from Patients with Generalized Anxiety Disorder? A Comparative Study

Mowla

Kalantarhormozi

Khazraee

2016

Iran J Psychiatry Behav Sci

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Background: Hyperthyroidism is associated with anxiety symptoms. Objectives: The aim of this study was to compare the clinical characteristics of patients with anxiety due to hyperthyroidism with patients with generalized anxiety disorder (GAD). Materials and Methods:This study was carried out in Abolfazl psychiatry clinic affiliated to Bushehr University of Medical Sciences from September 2012 to September 2013. Anxiety severity and characteristics of thirty-two patients with GAD was compared to 34 patients with anxiety due to hyperthyroidism. Hamilton anxiety rating scale (HAM-A) was used to evaluate the overall anxiety severity and anxiety symptom profile of the two groups. Results: There was no significant difference regarding overall anxiety severity between the two groups (P = 0.65). Autonomic symptoms were more sever in hyperthyroid patients (P = 0.003) whereas anxious mood and fears were more prominent in patients with GAD (P = 0.001 and P = 0.045, respectively). Conclusions: This study demonstrated that patients with GAD reported more psychology symptoms of anxiety whereas physical symptoms of anxiety were more prominent in hyperthyroid patients. Our findings may help differentiate these two disorders in the clinic, based on the symptom profile. However, it is important to note that this study is preliminary, and larger studies are needed to confirm the results.

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Neuropsychiatric Manifestations of Thyroid Disease

Cited by 78 publications

References 133 publications

Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia

Association between prolactin and thyroid hormones with severity of psychopathology and suicide risk in drug free male schizophrenia

Thyroid profile in depression: a cross-sectional study from North-East India

Dose the Clinical Characteristics of Patients with Anxiety due to Hyperthyroidism Differ from Patients with Generalized Anxiety Disorder? A Comparative Study

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