Neuropsychiatric sequelae of long COVID-19: Pilot results from the COVID-19 neurological and molecular prospective cohort study in Georgia, USA

Chen, Alex; Wang, Xiaoling; McCluskey, Lynnette Phillips; Morgan, John C.; Switzer, Jeffrey A.; Mehta, Rohini; Tingen, Martha S.; Su, Shaoyong; Harris, Ryan A.; Hess, David C.; Rutkowski, Elizabeth

doi:10.1016/j.bbih.2022.100491

Cited by 18 publications

(15 citation statements)

References 57 publications

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“…In fact, neurological symptoms such as fatigue and chronic headaches are among the most common symptoms presented by long COVID patients. A recent cohort study has reported over 66.5% (133/200) of COVID-19 patients suffering from lingering headaches about 4 months after testing positive for the virus 35 and yet, the etiology of long COVID-related chronic headaches is still not well characterized. Here, we used retrospective longitudinal blood specimens from early to late convalescence COVID-19 patients (prior and after the first headache diagnosis) experiencing prolonged headache and healthy controls to characterize the immuno-metabolic landscape in the onset of chronic headaches during acute infection phase and convalescence phase of PASC.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Immunometabolic rewiring in long COVID patients with chronic headache

Foo

Chen

Jung

et al. 2023

Preprint

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Almost 20% of patients with COVID-19 experience long-term effects, known as post-COVID condition or long COVID. Among many lingering neurologic symptoms, chronic headache is the most common. Despite this health concern, the etiology of long COVID headache is still not well characterized. Here, we present a longitudinal multi-omics analysis of blood leukocyte transcriptomics, plasma proteomics and metabolomics of long COVID patients with chronic headache. Long COVID patients experienced a state of hyper-inflammation prior to chronic headache onset and maintained persistent inflammatory activation throughout the progression of chronic headache. Metabolomic analysis also revealed augmented arginine and lipid metabolisms, skewing towards a nitric oxide-based pro-inflammation. Furthermore, metabolisms of neurotransmitters including serotonin, dopamine, glutamate, and GABA were markedly dysregulated during the progression of long COVID headache. Overall, these findings illustrate the immuno-metabolomics landscape of long COVID patients with chronic headache, which may provide insights to potential therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Immunometabolic rewiring in long COVID patients with chronic headache

Foo

Chen

Jung

et al. 2023

Preprint

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“…Recent literature regarding the long-term neuropsychiatric sequelae of COVID-19 focused on self-reported symptoms through questionnaires administered either in-person or by telephone interviews [ 52 , 53 , 54 ]. Notably, Long COVID has been found to cause anxiety and depression symptoms as well as other neuropsychiatric and cognitive sequelae [ 55 , 56 , 57 , 58 , 59 ].…”

Section: Cognitive Dysfunctions Psychiatric Symptoms and Behavioral A...mentioning

confidence: 99%

Psychological and Cognitive Effects of Long COVID: A Narrative Review Focusing on the Assessment and Rehabilitative Approach

Luca

Bonanno

Calabrò

2022

JCM

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Long COVID is a clinical syndrome characterized by profound fatigue, neurocognitive difficulties, muscle pain, weakness, and depression, lasting beyond the 3–12 weeks following infection with SARS-CoV-2. Among the symptoms, neurocognitive and psychiatric sequelae, including attention and memory alterations, as well as anxiety and depression symptoms, have become major targets of current healthcare providers given the significant public health impact. In this context, assessment tools play a crucial role in the early screening of cognitive alterations due to Long COVID. Among others, the general cognitive assessment tools, such as the Montreal Cognitive assessment, and more specific ones, including the State Trait Inventory of Cognitive Fatigue and the Digit Span, may be of help in investigating the main neurocognitive alterations. Moreover, appropriate neurorehabilitative programs using specific methods and techniques (conventional and/or advanced) through a multidisciplinary team are required to treat COVID-19-related cognitive and behavioral abnormalities. In this narrative review, we sought to describe the main neurocognitive and psychiatric symptoms as well as to provide some clinical advice for the assessment and treatment of Long COVID.

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“…30% of the participants showed hyposmia and 30% showed hypogeusia. In addition, selfreported symptoms were related to depression and anxiety [12].…”

Section: Vid-19 Neurological and Molecular Prospective Cohortmentioning

confidence: 99%

The Improvement of Pilot Fatigue Management

Choi

2023

Korean J Aerosp Environ Med

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The two pilots of Ethiopian Airlines flight ET343 Boeing 737-800, heading from Khartoum, Sudan to Addis Ababa, Ethiopia, fell asleep 37,000 feet in the air and temporarily lost radio communication with Air traffic Control (ATC) controllers and passed the landing airport on 22 August 22, 2022. The pilots woke up after the alarm sounded indicating the autopilot was released, and resumed communication with the ATC controller, landing 25 minutes later. Aviation expert Alex Macheras told the The British Broadcasting Corporation that it is a serious concern and that pilot fatigue is the most threatening factor in aviation safety internationally, requiring continuous management [1].In order to prevent aircraft accidents that may occur due to fatigue, this paper analyzes fatigue-related accident cases and previous research and suggests ways to improve the management of pilot fatigue. Ⅱ. MATERIALS AND METHODS Fatigue and management 1) DefinitionsThe International Civil Aviation Organization defines fatigue as a physiological state in which mental and physical performance is reduced due to sleep loss, increased waking hours, daily cycles, and heavy workloads [2].

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Neuropsychiatric sequelae of long COVID-19: Pilot results from the COVID-19 neurological and molecular prospective cohort study in Georgia, USA

Cited by 18 publications

References 57 publications

Immunometabolic rewiring in long COVID patients with chronic headache

Immunometabolic rewiring in long COVID patients with chronic headache

Psychological and Cognitive Effects of Long COVID: A Narrative Review Focusing on the Assessment and Rehabilitative Approach

The Improvement of Pilot Fatigue Management

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