Neuropsychiatric Symptoms and Risk Factors in Mild Cognitive Impairment: A Cohort Investigation of Elderly Patients

Yang, Aiping; Wang, X.-L.; Rui, Hua; Luo, Hao; Pang, Marco Yiu Chung; Dou, Xin‐Man

doi:10.1007/s12603-020-1312-9

Cited by 12 publications

(15 citation statements)

References 25 publications

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“…Most studies (n = 7 studies) [35][36][37][40][41][42]45 defined incident dementia using the DSM-IV criteria. 20,31 This was followed by NINCDS-ADRDA criteria 49,52 (n = 5 studies), [35][36][37][38][39] the NINDS-AIREN criteria 32 (n = 2 studies), 35,36 and DSM-III-R criteria 20 (n = 1 study 44 ).…”

Section: Diagnostic Criteria For Dementiamentioning

confidence: 99%

“…20,31 This was followed by NINCDS-ADRDA criteria 49,52 (n = 5 studies), [35][36][37][38][39] the NINDS-AIREN criteria 32 (n = 2 studies), 35,36 and DSM-III-R criteria 20 (n = 1 study 44 ). 44 Studies defined dementia as either all-cause (n = 7 studies), [35][36][37]41,[43][44][45] AD (n = 8 studies), [35][36][37][38][39][40]42,45 or vascular dementia (VaD; n = 2 studies). 36,45 One study 44 mentioned using International Classification of Diseases (ICD)-10 criteria from the World Health Organization.…”

Section: Diagnostic Criteria For Dementiamentioning

confidence: 99%

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Risk of conversion from mild cognitive impairment to dementia in low‐ and middle‐income countries: A systematic review and meta‐analysis

McGrattan

Pakpahan

Siervo

et al. 2022

A&D Transl Res & Clin Interv

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Introduction:With no treatment for dementia, there is a need to identify high risk cases to focus preventive strategies, particularly in low-and middle-income countries (LMICs) where the burden of dementia is greatest. We evaluated the risk of conversion from mild cognitive ompairment (MCI) to dementia in LMICs.Methods: Medline, Embase, PsycINFO, and Scopus were searched from inception until June 30, 2020. The search was restricted to observational studies, conducted in population-based samples, with at least 1 year follow-up. There was no restriction on the definition of MCI used as long as it was clearly defined. PROSPERO registration: CRD42019130958. Results:Ten thousand six hundred forty-seven articles were screened; n = 11 retained.Of the 11 studies, most were conducted in China (n = 7 studies), with only two studies from countries classified as low income. A qualitative analysis of n = 11 studies showed that similar to high-income countries the conversion rate to dementia from MCI was variable (range 6.0%-44.8%; average follow-up 3.7 years [standard deviation = 1.2]).

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Section: Diagnostic Criteria For Dementiamentioning

confidence: 99%

Section: Diagnostic Criteria For Dementiamentioning

confidence: 99%

Risk of conversion from mild cognitive impairment to dementia in low‐ and middle‐income countries: A systematic review and meta‐analysis

McGrattan

Pakpahan

Siervo

et al. 2022

A&D Transl Res & Clin Interv

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“…A total of 18 relevant studies were identified from the literature search after removal of duplicated and irrelevant literature and screening titles and abstracts. 14,[19][20][21][25][26][27][28][29][30][31][32][33][34][35][36][37][38] In all, 59 articles were read in full text for eligibility, and of these, 17 studies fulfilled the pre-specified inclusion criteria. One additional article was identified from a previously published meta-analysis.…”

Section: Literature Searchmentioning

confidence: 99%

“…The role of apathy in predicting progression from MCI to dementia has been further explored in recent longitudinal studies which present diverging results, [19][20][21] with varying incidence of dementia conversion possibly due to differences in follow-up time, cognitive instruments used and sex distribution among studies, and is still a matter of investigation. The present meta-analysis was performed to evaluate the evidence from longitudinal cohort studies for the potential association between apathy in individuals with MCI and risk of incident dementia.…”

Section: Introductionmentioning

confidence: 99%

Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies

Fresnais

Humble

Meehan

et al. 2022

J Geriatr Psychiatry Neurol

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Background Apathy is one of the most prevalent neurobehavioral manifestations in mild cognitive impairment (MCI) and is included among the behavioral and psychological symptoms of dementia (BPSD). Studies suggest that the presence of apathy could be associated with increased dementia risk. The role of apathy in conversion from MCI to dementia, and whether apathy could be a relevant predictor for dementia progression, are still matters of investigation. Aim To study the relationship between apathy and progression to dementia in individuals with MCI. Methods A systematic literature search in Medline, Embase, Cochrane Library, Epistemonikos, PsychINFO, and CINAHL was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search included longitudinal studies reporting on the association between apathy and dementia. Results The main outcome was pooled unadjusted hazard ratios (HR) of apathy in dementia conversion and included 11 studies with 9504 individuals. There was a significant association between apathy and dementia conversion, HR = 1.54; 95% CI, 1.29, 1.84. Subgroup analysis showed a significant association between apathy and progression to AD. Conclusion Apathy was associated with an increased risk of conversion to AD and all-cause dementia in patients with MCI. The role of apathy as a marker for incident dementia needs to be investigated in large, high-quality studies.

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“…Measuring psychological distress is notoriously difficult, given its multiple domains and definitions (Kivimaki & Steptoe, 2018), so most previous studies have relied on the assessment of particular aspects of psychological disturbance. Limited data have linked posttraumatic stress disorder (PTSD; Edmondson, Kronish, Shaffer, Falzon, & Burg, 2013; Flatt, Gilsanz, Quesenberry, Albers, & Whitmer, 2018; Wang et al., 2016; Yaffe et al., 2010), anxiety (Batelaan, Seldenrijk, Bot, van Balkom, & Penninx, 2016; Yang et al., 2020), anger (Sutin, Stephan, & Terracciano, 2018), and hostility (Chida & Steptoe, 2009; Sutin et al., 2018) with dementia. Similarly, depression, which is often a consequence of stressful experiences and has been conceptualized as part of stress spectrum disorders (Correll et al., 2017; Ritchie et al., 2020; Wager‐Smith & Markou, 2011; Yu, Jung, Go, Park, & Ha, 2020), has also shown to increase the risk of dementia by twofold (Byers & Yaffe, 2011).…”

Section: Introductionmentioning

confidence: 99%

Association between symptoms of psychological distress and cognitive functioning among adults with coronary artery disease

et al. 2020

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Greater psychological distress is associated with cognitive impairment in healthy adults. Whether such associations also exist in patients with coronary artery disease (CAD) is uncertain. We assessed cognitive function in 496 individuals with CAD using the verbal and visual memory subtests of the Wechsler Memory Scale and executive functioning measured by the Trail Making Test Parts A and B. We used a composite score of psychological distress derived through summation of Z‐transformed psychological distress symptom scales (depression, posttraumatic stress, anxiety, anger, hostility and perceived stress) and scores for each individual psychological scale. Multivariable linear regression models were used to determine the association between memory scores (as outcomes) and the psychological distress scores (both composite score and individual scales). After adjusting for demographic and cardiovascular risk factors, a higher psychological distress score was independently associated with worse memory and executive functioning. Each standard deviation increase in psychological distress score was associated with 3% (95% confidence interval [CI], 1%–5%) to 5% (95% CI, 3–7%) worse cognitive performance (higher Trail A and Trail B, and lower verbal and visual memory scores). Among individuals with CAD, a higher level of psychological distress is independently associated with worse cognitive performance. These findings suggest that psychological risk factors play a role in cognitive trajectories of persons with CAD.

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Neuropsychiatric Symptoms and Risk Factors in Mild Cognitive Impairment: A Cohort Investigation of Elderly Patients

Cited by 12 publications

References 25 publications

Risk of conversion from mild cognitive impairment to dementia in low‐ and middle‐income countries: A systematic review and meta‐analysis

Risk of conversion from mild cognitive impairment to dementia in low‐ and middle‐income countries: A systematic review and meta‐analysis

Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies

Association between symptoms of psychological distress and cognitive functioning among adults with coronary artery disease

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