Neuropsychiatric symptoms in a occipito-temporal infarction with remarkable long-term functional recovery

Tanev, Kaloyan S.; Federico, Lydia E.; Sydnor, Valerie J.; Leveroni, Catherine L.; Hassan, Khalid; Biffi, Alessandro

doi:10.1016/j.cortex.2021.01.013

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…In addition to CSD, several studies suggested that RLS had an impact on hemodynamics in the anterior and posterior circulation through frequent transit of micro-emboli or vasoactive substances bypassing the deactivating pulmonary filters ( 36 , 37 ). The posterior microcirculation abnormalities were related to the dysfunction of the autonomic system with the manifestation of photophobia ( 38 , 39 ). In addition, prior clinical surveys proved that paradoxical embolism induced by RLS could damage both cerebral and peripheral microcirculation, leading to an alteration of serotonin, pro-inflammatory bradykinin, or neurotensin metabolism ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Dong¹,

Ji²,

Li³

et al. 2023

Front. Neurol.

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BackgroundHypersensitivity to light is a common symptom associated with dysfunction of the occipital region. Earlier studies also suggested that clinically significant right-to-left shunt (RLS) could increase occipital cortical excitability associated with the occurrence of migraine. The aim of this study was to investigate the relationship between RLS and photosensitivity.MethodsThis cross-sectional observational study included the residents aged 18–55 years living in the Mianzhu community between November 2021 and October 2022. Photosensitivity was evaluated using the Photosensitivity Assessment Questionnaire along with baseline clinical data through face-to-face interviews. After the interviews, contrast-transthoracic echocardiography (cTTE) was performed to detect RLS. Inverse probability weighting (IPW) was used to reduce selection bias. Photosensitivity score was compared between individuals with and without significant RLS using multivariable linear regression based on IPW.ResultsA total of 829 participants containing 759 healthy controls and 70 migraineurs were finally included in the analysis. Multivariable linear regression analysis showed that migraine (β = 0.422; 95% CI: 0.086–0.759; p = 0.014) and clinically significant RLS (β = 1.115; 95% CI: 0.760–1.470; p < 0.001) were related to higher photosensitivity score. Subgroup analysis revealed that clinically significant RLS had a positive effect on hypersensitivity to light in the healthy population (β = 0.763; 95% CI: 0.332–1.195; p < 0.001) or migraineurs (β = 1.459; 95% CI: 0.271–2.647; p = 0.010). There was also a significant interaction between RLS and migraine for the association with photophobia (pinteraction = 0.009).ConclusionRLS is associated with photosensitivity independently and might exacerbate photophobia in migraineurs. Future studies with RLS closure are needed to validate the findings.Trial registrationThis study was registered at the Chinese Clinical Trial Register, Natural Population Cohort Study of West China Hospital of Sichuan University, ID: ChiCTR1900024623, URL: https://www.chictr.org.cn/showproj.html?proj=40590.

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Section: Discussionmentioning

confidence: 99%

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Dong¹,

Ji²,

Li³

et al. 2023

Front. Neurol.

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“…From the 13 articles, we extracted the demographic characteristics (ie, title, authors, year of publication, journal), the characteristics of the studied stroke sample (ie, sample size, age and sex of stroke sample, type of stroke, time since injury), the sensory modalities that were studied, and the results of the analysis relating poststroke subjective sensory hypersensitivity to lesion neuroanatomy. Based on the data extraction, we had to exclude nine articles: One did not study subjective sensory hypersensitivity (Bonan et al, 2015), one studied subjective sensory hypersensitivity after acquired brain injury but did not provide results that were specific to the included individuals with stroke (Berthold-Lindstedt et al, 2017), one studied tactile hyposensitivity in hemiplegic limbs (Aikio et al, 2021), one studied temperature allodynia limited to painful body parts (Klit et al, 2011), one studied photophobia during a migraine episode with comorbid hemianopia (Tanev et al, 2021), three did not mention the neuroanatomy of poststroke subjective sensory hypersensitivity specifically (Alwawi et al, 2020; Carlsson et al, 2004, 2009), and one studied auditory illusions (palinacousis and paracusis) (Fukutake and Hattori, 1998).…”

Section: Methodsmentioning

confidence: 99%

The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity

Thielen

Tuts

Lafosse

et al. 2023

Cognitive and Behavioral Neurology

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Background: Although subjective sensory hypersensitivity is prevalent after stroke, it is rarely recognized by health care providers, and its neural mechanisms are largely unknown. Objective: To investigate the neuroanatomy of poststroke subjective sensory hypersensitivity as well as the sensory modalities in which subjective sensory hypersensitivity can occur by conducting both a systematic literature review and a multiple case study of patients with subjective sensory hypersensitivity. Method: For the systematic review, we searched three databases (Web of Science, PubMed, and Scopus) for empirical articles discussing the neuroanatomy of poststroke subjective sensory hypersensitivity in humans. We assessed the methodological quality of the included studies using the case reports critical appraisal tool and summarized the results using a qualitative synthesis. For the multiple case study, we administered a patient-friendly sensory sensitivity questionnaire to three individuals with a subacute right-hemispheric stroke and a matched control group and delineated brain lesions on a clinical brain scan. Results: Our systematic literature search resulted in four studies (describing eight stroke patients), all of which linked poststroke subjective sensory hypersensitivity to insular lesions. The results of our multiple case study indicated that all three stroke patients reported an atypically high sensitivity to different sensory modalities. These patients’ lesions overlapped with the right anterior insula, the claustrum, and the Rolandic operculum. Conclusion: Both our systematic literature review and our multiple case study provide preliminary evidence for a role of the insula in poststroke subjective sensory hypersensitivity and suggest that poststroke subjective sensory hypersensitivity can occur in different sensory modalities.

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Neuropsychiatric symptoms in a occipito-temporal infarction with remarkable long-term functional recovery

Cited by 2 publications

References 37 publications

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

Connection between right-to-left shunt and photosensitivity: a community-based cross-sectional study

The Neuroanatomy of Poststroke Subjective Sensory Hypersensitivity

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