Neuropsychiatric Symptoms in Amnestic Mild Cognitive Impairment: Increased Risk and Faster Progression to Dementia

Somme, Johanne; Fernández-Martı́nez, Manuel; Molano, Ana; Zarranz, J.J.

doi:10.2174/1567205011310010012

Cited by 34 publications

(53 citation statements)

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“…Further, the impact of depression developing after baseline on conversion has not been reported(15, 16). While depression is an exclusion criterion for enrollment into ADNI, 8% of aMCI participants developed clinically significant depression symptoms during follow-up, an incidence rate similar to the general population(50).…”

Section: Discussionmentioning

confidence: 99%

“…One of the first studies to demonstrate a nearly two-fold increased AD risk in individuals with aMCI and anxiety reported that anxiety at baseline remained a significant predictor when depression was included as a covariate, although the results were not presented(17). Other studies which demonstrated an association between aMCI with anxiety and conversion excluded depression as a covariate in longitudinal models of AD risk(15, 16, 18). Thus, while evidence from large observational studies supports an association between anxiety in aMCI and AD risk, the degree to which depression contributes towards, or confounds the association is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease

Mah

Binns

Steffens

2015

The American Journal of Geriatric Psychiatry

138

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Background The purpose of the current study was to test the hypothesis that anxiety in amnestic mild cognitive impairment (aMCI) increases rates of conversion to Alzheimer's disease (AD), and to identify potential neural mechanisms underlying such an association. Methods 376 participants with aMCI from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were studied over a median period of 36 months. A Cox proportional-hazards model was used to assess the association between anxiety severity ratings on the Neuropsychiatric Inventory Questionnaire and AD risk. Other variables in the model were depression, memory loss, and MRI-derived AD-related regions-of-interest (ROI), including hippocampal (HC), amygdalar (AMYG), entorhinal cortical (EC) volumes and EC thickness, In addition, a linear regression model was used to determine the effect of anxiety in aMCI on rates of atrophy within ROIs. Results Anxiety severity increased rate of aMCI conversion to AD, after controlling for depression and cognitive decline. The association between anxiety and AD remained significant even with inclusion of ROI baseline values or atrophy rates as explanatory variables. Further, anxiety status predicted greater rates of decrease in EC volume. An association between anxiety and EC-thickness missed significance. Conclusions Anxiety symptoms in aMCI predict conversion to AD, over and beyond the effects of depression, memory loss, or atrophy within AD neuroimaging biomarkers. These findings, together with the greater EC atrophy rate predicted by anxiety, are compatible with the hypothesis that anxiety is not a prodromal non-cognitive feature of AD, but may accelerate decline towards AD through direct or indirect effects on EC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease

Mah

Binns

Steffens

2015

The American Journal of Geriatric Psychiatry

138

View full text Add to dashboard Cite

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“…That diurnal rhythm disturbances are associated with no progression to AD is surprising, as circadian rhythm disturbances are frequent in AD [52][53][54] and in some studies even a predictor for the progression to dementia [55]. An explanation for our finding can be a lack of sensitivity of the Behave-AD cluster diurnal rhythm disturbances (that only consists of one item) in progressive MCI patients, as it is also known to be difficult to obtain accurate self-reports on sleep in demented patients [56].…”

Section: Discussionmentioning

confidence: 99%

Depression in Mild Cognitive Impairment is associated with Progression to Alzheimer's Disease: A Longitudinal Study

Mussele

Fransén

Struyfs

et al. 2014

JAD

113

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“…Each sub-level variable was assigned a weighted score and then summed to yield one CAIDE score per subject [17]. Anxiety, apathy, and depression variables from the Neuropsychiatric Inventory Questionnaire (NPI-Q) [22] in the NACC UDS packet were chosen based on their known associations with MCI progression to dementia [23, 24] and lack of data on their associations with MCI reversion to normal cognition.…”

Section: Methodsmentioning

confidence: 99%

Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition

Pandya

Lacritz

Weiner

et al. 2017

Dement Geriatr Cogn Disord

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Background/Aims: Few studies have examined predictors of reversion from mild cognitive impairment (MCI) to normal cognition. We sought to identify baseline predictors of reversion, using the National Alzheimer's Coordinating Center Uniform Data Set, by comparing MCI individuals who reverted to normal cognition to those who progressed to dementia. Methods: Participants (n = 1,208) meeting MCI criteria were evaluated at the baseline visit and 3 subsequent annual visits. Clusters of baseline predictors of MCI reversion included demographic/genetic data, global functioning, neuropsychological functioning, medical health/dementia risk score, and neuropsychiatric symptoms. Stepwise logistic regression models identified predictors of MCI reversion per cluster, which were then entered into a final comprehensive model to find overall predictor(s). Results: At 2 years, 175 (14%) reverted to normal cognition, 612 (51%) remained MCI, and 421 (35%) progressed to dementia, with sustained diagnoses at 3 years. Significant variables associated with MCI reversion were younger age, being unmarried, absence of APOE ε4 allele, lower CDR-SOB score, and higher memory/language test scores. Conclusion: A relatively sizable proportion of MCI individuals reverted to normal cognition, which is associated with multiple factors previously noted. Findings may enhance MCI prognostic accuracy and increase precision of early intervention studies of dementia.

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Neuropsychiatric Symptoms in Amnestic Mild Cognitive Impairment: Increased Risk and Faster Progression to Dementia

Abstract: Assessing a broad spectrum of NPS can help identify patients with a-MCI presenting a higher risk for progression to dementia. This can be useful to select patients for closer follow-up, clinical trials and future therapeutic interventions.

Cited by 34 publications

References 0 publications

Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease

Anxiety Symptoms in Amnestic Mild Cognitive Impairment Are Associated with Medial Temporal Atrophy and Predict Conversion to Alzheimer Disease

Depression in Mild Cognitive Impairment is associated with Progression to Alzheimer's Disease: A Longitudinal Study

Predictors of Reversion from Mild Cognitive Impairment to Normal Cognition

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