Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease

Ojagbemi, Akin; Akinyemi, Rufus; Baiyewu, Olusegun

doi:10.1111/ane.12062

Cited by 14 publications

(23 citation statements)

References 27 publications

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“…Cutoff points validated against a clinical diagnosis were used for the AES, for the AS by all but one study, for the LARS (≥–16) by two studies, and for the NPI (≥4) by one study . More sensitive cutoff points were used in one study employing the LARS (≥–22), and five studies employing the NPI (≥1) . Three studies reported prevalence rates for both the ≥1 and the ≥4 point cutoff points on the NPI .…”

Section: Resultsmentioning

confidence: 99%

“…Research into the pathophysiology and treatment of apathy may be hampered by clinical correlates with overlapping symptoms . Depression, cognitive impairment, fatigue . and physical constraint, may all lead to higher apathy ratings.…”

Section: Discussionmentioning

confidence: 99%

“…2,20,[39][40][41][42][43][44] Study and population characteristics are listed in Table 1. Eleven studies employed the AS to measure apathy, 4,10,23,24,27,30,32,34,35,37,38 10 studies the NPI apathy item, [15][16][17]25,26,28,29,31,36 three studies the LARS, 17,21,33 and one study the AES. 22 Cutoff points validated against a clinical diagnosis were used for the AES, for the AS by all but one study, 10 for the LARS (-16) by two studies, 17,21 and for the NPI (4) by one study.…”

Section: Study Selectionmentioning

confidence: 99%

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Apathy in Parkinson's disease: A systematic review and meta‐analysis

et al. 2015

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Apathy is a frequently reported neuropsychiatric symptom in Parkinson's disease (PD), but its prevalence and clinical correlates are debated. We aimed to address these issues by conducting a systematic review and meta-analysis. Embase, Medline/PubMed, and PsychINFO databases were searched for relevant studies. Data were extracted by two independent observers, using predefined extraction forms tailored specifically to the research question. From 1,702 titles and abstracts, 23 studies were selected. Meta-analysis showed a prevalence of apathy in PD of 39.8% (n = 5,388, 905% CI 34.6-45.0%). Apathy was associated with higher age (3.3 years, 95% CI = 1.7-4.9), lower mean Mini-Mental State Evaluation (MMSE) score (-1.4 points, 95% CI = -2.1 to -0.8), an increased risk of co-morbid depression (relative risk [RR] = 2.3, 95% CI = 1.9-2.8), higher Unified Parkinson's Disease Rating Scale (UPDRS) motor score (6.5 points, 95% CI = 2.6-10.3), and more severe disability (Hedges-G = 0.5, 95% CI = 0.3-0.6). Half of the patients with apathy had concomitant depression (57.2%, 95% CI = 49.4-64.9%), and this estimate was similar after exclusion of patients with cognitive impairment (52.5%, 95% CI = 42.2%-62.8%). In conclusion, we found that apathy affects almost 40% of patients with PD. Several factors influence reported prevalence rates, contributing to the considerable heterogeneity in study results. Half of patients with apathy do not suffer from concomitant depression or cognitive impairment, confirming its status as a separate clinical syndrome in PD. The pervasiveness of apathy in PD warrants research into its treatment, although different underlying pathophysiological mechanisms may require different treatment strategies. Treatment of apathy could improve patient quality of life, reduce caregiver burden, alleviate disability by increasing motivation for self-care, and reduce cognitive impairment by improving executive functioning.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

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Apathy in Parkinson's disease: A systematic review and meta‐analysis

et al. 2015

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“…Also, cultural, social and family structure might be responsible for differences [7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…Neuropsychiatric symptoms (NPS) are part of the nonmotor manifestation of PD, and have a significant impact on the quality of life [QoL] of PD patients, and on a caregiver burden and distress [presence of NPS apart from dementia is associated with caregiver distress] [8,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric symptoms in Serbian patients with Parkinson's disease

Petrovic

Stefanova

Ziropadja

et al. 2016

Journal of the Neurological Sciences

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Neuroscience in Nigeria: the past, the present and the future

2017

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The science of the brain and nervous system cuts across almost all aspects of human life and is one of the fastest growing scientific fields worldwide. This necessitates the demand for pragmatic investment by all nations to ensure improved education and quality of research in Neurosciences. Although obvious efforts are being made in advancing the field in developed societies, there is limited data addressing the state of neuroscience in sub-Saharan Africa. Here, we review the state of neuroscience development in Nigeria, Africa's most populous country and its largest economy, critically evaluating the history, the current situation and future projections. This review specifically addresses trends in clinical and basic neuroscience research and education. We conclude by highlighting potentially helpful strategies that will catalyse development in neuroscience education and research in Nigeria, among which are an increase in research funding, provision of tools and equipment for training and research, and upgrading of the infrastructure at hand.

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Neuropsychiatric symptoms in Nigerian patients with Parkinson's disease

Abstract: Neuropsychiatric symptoms occur more frequently in Parkinson's disease than matched controls, and the presence of these symptoms is associated with caregivers' distress. There is a need for early and adequate treatment for motor and behavioural symptoms of Parkinson's disease.

Cited by 14 publications

References 27 publications

Apathy in Parkinson's disease: A systematic review and meta‐analysis

Apathy in Parkinson's disease: A systematic review and meta‐analysis

Neuropsychiatric symptoms in Serbian patients with Parkinson's disease

Neuroscience in Nigeria: the past, the present and the future

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