Neuropsychiatric Systemic Lupus Erythematosus Presenting as Bipolar I Disorder With Catatonic Features

Retrospective chart review of catatonia in child and adolescent psychiatric patients

“…Systematic studies of catatonia find that it is a relatively common condition among psychiatric patients; one cross-cultural study found rates ranging between 10% and 13% (13). Others have found that certain diagnostic groups may be at a relatively higher risk such as autism ⁄ pervasive developmental disorders (PDD) (14), mental retardation and other developmental disabilities (14), affective disorders (15,16), and schizophrenia (17,18). Among a long list of associated medical conditions are some specific conditions as encephalitis (19), meningitis (20), secondary to antipsychotic medications (21), toxins and infections (22)(23)(24).…”

Antinuclear antibodies testing as a routine screening for systemic lupus erythematosus in patients presenting first‐episode psychosis

“…These results demonstrated a neuropathogenic potential of anti-P antibodies that can contribute as a mechanistic basis for psychiatric lupus. 14 In psychiatric settings, the current understanding about the association of psychiatric manifestation and NPSLE is largely based on case reports, with the diagnosis of NPSLE being made after a long period of time 15 or preceded by clinical abnormalities suggestive of a general medical condition. 16,17 To the best of our knowledge, this is the first report of a routine clinical investigation actively looking for the occurrence of NPSLE in FEP, which was found in 2.4% of the sample studied.…”

The association between systemic lupus erythematosus and bipolar disorder – a big data analysis

“…report that mania was found in 3% of SLE patients and BD was found in 5.8% of SLE patients; several case reports confirm that mania may be the first manifestation of SLE [12,17,18]. In a recent report, we described an association between SLE and schizophrenia after adjusting for age, gender, smoking and socioeconomic status (SES) [19].…”

“…Increased disease activity on the SLEDAI was found to be independently associated with depression [11]. However, the onset of mood symptoms can occur anytime in the course of SLE and regardless of the disease activity level [12]. The exact mechanism behind these symptoms is yet to be determined; several theories have been proposed, including an antibody mediated vascular compromise affecting both neurons and the blood-brain-barrier, antibody mediated neuronal damage and accelerated atherosclerosis [5,13,14].…”