Neuropsychologic Alterations in Classic and Common Migraine

Hooker, William D.; Raskin, Neil H.

doi:10.1001/archneur.1986.00520070065020

Cited by 96 publications

(141 citation statements)

References 25 publications

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“…32 If verbal impairment were a consequence of the cumulative effects of headache attacks, one would expect that individuals with a longer history of headache would perform more poorly than those with a shorter history. In our study, as in others, cognitive performance was unrelated to length of headache history, 10,12,33-34 medication use, 12 or severity and duration of migraine attack. 10,13 Moreover, because migraineurs performed significantly more poorly than those with TTH on verbal measures at ages 3, 7, 9, 11, and 13, the effect does not appear to be attributable to the negative influence of headache pain and discomfort in general or reduced educational opportunities.…”

Section: Figure 2 the Mean Verbal Iq Scores Across Four Childhood Asupporting

confidence: 86%

“…Functional and electrophysiologic alterations in cortical functioning have been found during the migraine interval, [1][2][3][4][5] which may be associated with cognitive impairment as demonstrated on tests of perception, 6,7 psychomotor ability, 8 attention, [9][10][11] and verbal memory. 12,13 However, not all studies have found such cortical alterations 14 or cognitive performance decrements. 15,16 Thus, it remains unclear whether migraine is associated with cognitive efficiency and, if so, to what degree and specificity.…”

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confidence: 99%

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Migraine and cognitive function

Waldie¹,

Hausmann²,

Milne³

et al. 2002

Neurology

104

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Abstract-Objective:To investigate the association between migraine and cognitive ability among members of a longitudinal birth cohort study. Methods: Headache status was determined at age 26 (migraine, tension-type headache [TTH], headache-free control subjects) according to International Headache Society criteria, and data relating to cognitive and academic performance from ages 3 to 26 years were analyzed. Results: Study members diagnosed with migraine were subtly but significantly impaired, compared with those with TTH and headache-free control subjects, on tests of verbal ability (especially language reception) from ages 3 to 13, independent of headache history. Performance on other tasks, including reading, arithmetic, motor, and spatial ability, was normal. The association between migraine and verbal functioning also appeared to impact on later academic success. Conclusion: Findings suggest that the poorer verbal performance was unlikely to have resulted from cumulative attacks and may be due to developmental factors beginning in utero.

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Section: Figure 2 the Mean Verbal Iq Scores Across Four Childhood Asupporting

confidence: 86%

mentioning

confidence: 99%

Migraine and cognitive function

Waldie¹,

Hausmann²,

Milne³

et al. 2002

Neurology

104

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“…Neuropsychological impairment in migraineurs has been described since 1986 [20,26]. Deficits in attention, early visual processing [27,28], memory [20][21][22][23][24][25], and psychomotor abilities [20,24,29] were reported in patients with migraine with aura assessed in the interictal period [30].…”

Section: Discussionmentioning

confidence: 99%

“…Deficits in attention, early visual processing [27,28], memory [20][21][22][23][24][25], and psychomotor abilities [20,24,29] were reported in patients with migraine with aura assessed in the interictal period [30]. Cognitive impairment involving memory and psychomotor abilities was also shown in subjects with migraine without aura [20,30].…”

Section: Discussionmentioning

confidence: 99%

Neuropsychologic phenotypes in familial hemiplegic migraine

Roccella

2003

J Headache Pain

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The 3 adolescents studied are from a large family in which the mother and 6 of 8 children are affected by FHM. The affected children are 4 males aged 33, 30, 15 and 13 years, and 2 females aged 30 and 10 years. Convulsions with fever were reported by the Michele RoccellaAbstract Familial hemiplegic migraine (FHM) is a rare autosomal dominant-type migraine with aura. Attacks are characterised by hemiparesis in addition to other aura and migraine symptoms. Few studies have examined the influence of FHM on cognitive functions. This study was aimed to investigate neuropsychological functions in 3 adolescent siblings suffering from FHM assessed six months after the last attack. No relevant deficits were found on a battery of multisectorial tests exploring cognitive functions. Sporadic FHM attack therefore seems not to affect cognition in these patients, at least far from the crises.

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“…Brain based changes have been suggested including deep white matter lesions, cerebral hypo perfusion, reduced parietal and frontal gray matter, and cerebellar atrophy [20][21][22][23][24][25]. Studies over the past few decades have revealed weaknesses in psychomotor ability, memory, processing speed, visual processing, attention, and executive functioning [1,[26][27][28][29][30][31][32][33]. Cognitive impairments are thought to be the result of either physiological dynamics preceding a migraine or of pronounced post-attack effects.…”

Section: Migrainesmentioning

confidence: 99%

Neuropsychological Profile of Hemiplegic Migraines: A Pediatric Case Study

Loughan¹,

Perna²,

Lee³

et al. 2014

JPCPY

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MigraineMigraine is the second most common type of headache and a disabling brain disorder that consists of recurrent attacks of unilateral headaches that are often experienced in conjunction with nausea, phonophobia, and photophobia [1,2]. Prior to the headache, one may experience an aura, or transient neurological symptoms, most often visual. The cumulative lifetime incidence of migraine is 43% in women and 18% in men [3] and is the leading cause for individuals to seek medical attention at neurological facilities [1]. Prevalence estimates indicate that up to 10.6% of children ages 5 to 15 years and 28% of adolescents between the ages of 15 and 19 years suffer with migraines [4]. Despite its prevalence, migraine remains commonly undiagnosed or misdiagnosed, in both children and adults [5][6][7]. In children, frequent headaches can cause a significant impact on educational functioning [8], as well as quality of life, prompting the need for early recognition and treatment. The long-term outcome of childhood headaches and evolution into adult headaches remains largely unknown.The patho physiology of migraines is complex and is thought to be caused by changes in the brainstem and its interactions with the trigeminal nerve, a major pain pathway. Moreover, serotonin imbalance is thought to exacerbate and contribute to migraines. Stewart et al [3] suggests that the common occurrence of migraine may be linked to minor perturbations of normal brain function. Migraine pain begins with the activation of meningeal nociceptive trigeminal sensory afferents, which leads to are lease of vasoactive neuropeptides at their peripheral nerve terminals. Subsequently, there is an activation of second-order neurons in the trigeminal nucleus caudalis and then an activation of brain structures involved in the processing and perception of pain [2]. The process of maintaining the severe prolonged pain of migraine headache is attributed to the sensitization of meningeal nociceptors and sensitization of central neurons of the trigemino vascular system. There is a strong genetic component but causative genes have not been identified, except for familial hemiplegic migraine. Hemiplegic migraineHemiplegic migraine (HM) is a rare form of migraine with transient hemiplegia during the aura phase characterized by AbstractThe clinical interview is an important part of a pediatric neuropsychological evaluation. Investigating the history of symptoms, the family, and genetic factors can often clarify etiological information. This manuscript will review a case of a 12 year old girl (HA) who has a family history of migraine headaches, but had previously been diagnosed and treated as a child with multiple mild grade 1 concussions. These suspected concussions were purportedly resulting in infrequent, but intermittent hemiplegic migraines. Specifically, HA suffered Hemiplegic Migraines which involved right dominant hand hemiplegia and significantly altered level of consciousness for approximately 12-24 hours, resulting in a full return to physical and co...

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Neuropsychologic Alterations in Classic and Common Migraine

Cited by 96 publications

References 25 publications

Migraine and cognitive function

Migraine and cognitive function

Neuropsychologic phenotypes in familial hemiplegic migraine

Neuropsychological Profile of Hemiplegic Migraines: A Pediatric Case Study

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