Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study.

Copeland, Donna R.; Moore, Bartlett D.; Francis, Deborah; Jaffe, Norman; Culbert, Steven J.

doi:10.1200/jco.1996.14.10.2826

Cited by 148 publications

(95 citation statements)

References 44 publications

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“…Although age at diagnosis as a predictor of pursuit accuracy and of pursuit stability does not reach significance in our study, our finding of a trend level effect suggests that a young age at diagnosis as a risk factor for worse visuomotor performance in survivors of ALL may be worthy of further study. This association would be in accordance with previous studies that report a younger age at diagnosis as a risk factor for worse cognitive performance in survivors of ALL (Copeland et al, 1996;Von der Weid et al, 2003), suggesting a greater vulnerability of less mature brain structures to neurotoxic insult (Ciesielski et al, 1999).…”

Section: Discussionsupporting

confidence: 93%

“…CNSdirected chemotherapy for ALL, consisting of intrathecal methotrexate, alone or in combination with cytarabine and corticosteroids, and of systemic methotrexate and corticosteroids, is associated with central neurotoxicity (Kerr et al, 2001;Surtees et al, 1998). Various studies have demonstrated visuomotor deficits in relationship with other cognitive impairments in children with ALL after treatment with chemotherapy only (Copeland et al, 1996;Kingma et al, 2001;Lesnik et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…As risk factors for poorer cognitive performance after childhood ALL treated with chemotherapy only, female gender (Brown et al, 1998;Von der Weid et al, 2003;Waber et al, 1992) and a young age at diagnosis (Copeland et al, 1996;Von der Weid et al, 2003) have been reported.…”

Section: Introductionmentioning

confidence: 99%

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Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Buizer

Sonneville

Heuvel‐Eibrink

et al. 2005

J. Inter. Neuropsych. Soc.

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Treatment for childhood acute lymphoblastic leukemia (ALL), which includes CNS prophylaxis, is associated with central and peripheral neurotoxicity. The purpose of the present study was to analyze the effects of chemotherapy on various levels of visuomotor control in survivors of childhood ALL treated without cranial irradiation, and to identify risk factors for possible deficits. Visuomotor function was compared between children after treatment for ALL (n 5 34), children after treatment for Wilms tumor, which consists of non-CNS directed chemotherapy (n 5 38), and healthy controls (n 5 151). Three tasks were administered: a simple visual reaction time task and two tasks measuring visuomotor control with one requiring a higher level of cognitive control than the other. Visuomotor deficits were detected only in the ALL group, with poorer performance restricted to the condition requiring the highest level of control. Significant risk factors for poorer performance were female gender and a short time since end of treatment, and a trend was found for a young age at diagnosis. A high cumulative methotrexate dose was an adverse predictive factor in girls. The results indicate that chemotherapy-induced central neurotoxicity in childhood ALL treatment is associated with higher order visuomotor control deficits. Girls appear to be particularly vulnerable. (JINS, 2005, 11, 554-565.)

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

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Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Buizer

Sonneville

Heuvel‐Eibrink

et al. 2005

J. Inter. Neuropsych. Soc.

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“…Due to the lack of sufficient data from pediatric GSCT patients, the suspected impact of treatment on cognitive functioning has been extrapolated from other diseases and treatments, ie cranial irradiation and chemotherapy for acute lymphocytic leukemia (ALL) or CNS tumors, [1][2][3][4][5][6] the effects of which were demonstrated to be dose-and agerelated. It has been hypothesized that pre-HSCT conditioning regimens, including total body irradiation (TBI) have a detrimental effect on children undergoing HSCT.…”

mentioning

confidence: 99%

Cognitive and psychosocial functioning of pediatric hematopoietic stem cell transplant patients: A prospective longitudinal study

Kupst

Penati

Debban

et al. 2002

Bone Marrow Transplant

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Summary:A prospective longitudinal study of cognitive and psychosocial functioning in pediatric hematopoietic stem cell transplant (HSCT) patients was conducted on three occasions: pre-HSCT, 1 year post-HSCT, and 2 years post-HSCT. In contrast to the previous hypothesis that cognitive declines would occur as a result of HSCT treatment, it was hypothesized that (1) global cognitive functioning (IQ scores), as well as specific areas would remain stable over time; (2) pre-transplant functioning would be predictive of later functioning; and (3) age would be negatively related to cognitive functioning. Based on previous research it was further hypothesized: that (4) while declines in psychosocial functioning might be seen at 1 year, functioning would improve by 2 years. 153 children and adolescents were evaluated pre-HSCT and at 1 year, with 2 year data available for 74 children. Advances in pediatric hematopoietic stem cell transplantation (HSCT) have resulted in increased survival and greater attention to long-term effects of treatment. Mortality remains relatively high in this population, however, and accumulation of data from a sufficient number of patients who survive this treatment involves many years. As a result, our understanding of the cognitive and behavioral Correspondence: MJ Kupst,

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“…Copeland et al (20) concluded that children with cerebellar tumors and non-irradiation therapy in early infancy have only minimal declines in neurocognitive development compared with patients treated with cranial radiotherapy. Further, this group emphasized the possible late effects of intrathecal chemotherapy (21). Mulhern et al observed a decline of the IQ scores in patients treated for ALL with cranial radiation and intrathecal methotrexate or with chemotherapy (22).…”

Section: Discussionmentioning

confidence: 99%

Survivors of Childhood Cancer for More than Twenty Years

Humpl

Fritsche²,

Bartels³

et al. 2001

Acta Oncologica

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Neuropsychologic effects of chemotherapy on children with cancer: a longitudinal study.

Cited by 148 publications

References 44 publications

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Visuomotor control in survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only

Cognitive and psychosocial functioning of pediatric hematopoietic stem cell transplant patients: A prospective longitudinal study

Survivors of Childhood Cancer for More than Twenty Years

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