Learning disabilities are a heterogeneous and common group of disorders that have a relevant impact on children’s academic function. The most common learning disorders consist of dyslexia, dyscalculia, dysgraphia or other non-verbal learning disorders. These disorders are commonly associated with neurological or behavioral disorders such as attention-deficit hyperactivity disorders. Understanding of cognitive and mental problems of children with learning disorders is an interesting challenge, and various approaches have been applied for their study, including medical, genetic, educational, epidemiologic and experimental psychologist. Nowadays, clinical neuropsychological approach, which is based on neurocognitive models, is one of the best existing models for description and interpretation of learning disorders. This approach assumes that there is a strong relationship between the various learning deficits and brain functioning. This paper consists of a descriptive review about components of a specialized neuropsychological approach that can be applied for the assessment of children with learning disabilities.