Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving cerebral malaria and children with HIV

Boivin, Michael J.; Bangirana, Paul; Tomac, Rachelle A.; Parikh, Sujal M.; Opika-Opoka, Robert; Nakasujja, Noeline; Nakakeeto, Margaret; John, Chandy C.; Giordani, Bruno

doi:10.1186/1753-6561-2-s1-p7

Cited by 12 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[7] It has also been validated in the sub-Saharan African context, [8–11] and previously adapted for use in pediatric HIV research in the present study site countries of Uganda and South Africa. [1, 12–17] Using the Luria model for neuropsychological assessment within the KABC-II, the primary outcome variables were the global scores of Sequential Processing (memory), Simultaneous Processing (visual-spatial processing and problem solving), Learning (immediate and delayed memory), Planning (executive reasoning), Delayed recall, nonverbal index (NVI) (subtests not dependent on the understanding of instructions in English) and Mental Processing Index (MPI) (a composite of the principal cognitive performance domains). The KABC offers the option of scoring using time points, but these were not used in the present assessment.…”

Section: Methodsmentioning

confidence: 99%

Neuropsychological performance in African children with HIV enrolled in a multisite antiretroviral clinical trial

Boivin¹,

Barlow‐Mosha

Chernoff

et al. 2018

Aids

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Neuropsychological performance in African children with HIV enrolled in a multisite antiretroviral clinical trial

Boivin¹,

Barlow‐Mosha

Chernoff

et al. 2018

Aids

View full text Add to dashboard Cite

show abstract

“…Despite knowledge of deficits in PHIV+ children, there have been very few intervention studies. One intervention is computerized cognitive rehabilitation training [67, 68]. Preliminary results in Uganda indicate that using computer games for cognitive rehabilitation can be of great benefit to PHIV+ children and adolescents [69].…”

Section: Intervention Strategiesmentioning

confidence: 99%

Neurodevelopment in perinatally HIV‐infected children: a concern for adolescence

Laughton

Cornell

Boivin

et al. 2013

Journal of the International AIDS Society

167

152

View full text Add to dashboard Cite

Globally, an estimated 3.4 million children are living with HIV, yet little is known about the effects of HIV and antiretroviral treatment (ART) on the developing brain, and the neurodevelopmental and behavioural outcomes of perinatally HIV-infected (PHIV+) adolescents.We reviewed the literature on neurodevelopmental outcomes in PHIV+ children and adolescents, and summarized the current evidence on behaviour, general cognition, specific domains, hearing and language, school performance and physical disabilities due to neurological problems.Evidence suggests that PHIV+ children do not perform as well as controls on general cognitive tests, processing speed and visual–spatial tasks, and are at much higher risk for psychiatric and mental health problems. Children with AIDS-defining diagnoses are particularly at risk for poorer outcomes.A striking finding is the lack of published data specific to the adolescent age group (10–25 years), particularly from resource-constrained countries, which have the highest HIV prevalence. In addition, extreme heterogeneity in terms of timing and source of infection, and antiretroviral experience limits our ability to summarize findings of studies and generalize results to other settings.Due to the complex nature of the developing adolescent brain, environmental influences and variation in access to ART, there is an urgent need for research on the longitudinal trajectory of neurodevelopment among children and adolescents perinatally infected with HIV, especially in high burden resource-constrained settings.

show abstract

“…This is so that psychological support and treatment services can be developed in low-resource settings with a high prevalence of adolescents with HIV. Figure 1 is based on a conceptual model proposed by Walker and colleagues[87, 88] and illustrates how our assessment plan was used to evaluate the neuropsychological benefits of CCRT in Ugandan school-age children with HIV [83, 89–91]. This work could eventually be the basis for a similar intervention plan extending into adolescence for children especially at risk.…”

Section: Introductionmentioning

confidence: 99%

CNS Impact of Perinatal HIV Infection and Early Treatment: the Need for Behavioral Rehabilitative Interventions Along with Medical Treatment and Care

2016

View full text Add to dashboard Cite

There is growing concern that although the more severe forms of HIV associated neurologic deficits are reduced following highly active anti-retroviral therapy (HAART), mild to moderate cognitive disorders may persist for years after HAART initiation and this may occur despite complete plasma viral suppression. According to the UNAIDS 2014 report, there were 3.2 million children living with HIV around the world at the end of 2013 and 91% of these resided in sub-Sahara Africa. In the same year only 24% of children who needed antiretroviral treatment (ART) received it and 190,000 children died of AIDS-related illnesses. We propose that behavioral interventions are needed in combination with medical treatment and care in order to fully address the needs of children and adolescents in Africa living with HIV. In early childhood, caregiver training programs to enhance the developmental milieu of the child with HIV can enhance their cognitive and social development, and that such interventions are both feasible and well-accepted by the local population. For school-age children, computerized cognitive rehabilitation training can be an entertaining and engaging way to improve attention, working memory, and problem solving skills for children with HIV. Further dissemination and implementation science work is needed for arriving at cost effective strategies for scaling up such behavioral interventions in African resource-constrained settings, given that the vast majority of HIV-affected children and youth worldwide presently live in sub-Sahara Africa.

show abstract

Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving cerebral malaria and children with HIV

Abstract: Publish with Bio Med Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical researc h in our lifetime."

Cited by 12 publications

References 0 publications

Neuropsychological performance in African children with HIV enrolled in a multisite antiretroviral clinical trial

Neuropsychological performance in African children with HIV enrolled in a multisite antiretroviral clinical trial

Neurodevelopment in perinatally HIV‐infected children: a concern for adolescence

CNS Impact of Perinatal HIV Infection and Early Treatment: the Need for Behavioral Rehabilitative Interventions Along with Medical Treatment and Care

Contact Info

Product

Resources

About