Neuropsychological changes in frontal functions with aging

Whelihan, William M.; Lesher, Emerson L.

doi:10.1080/87565648509540321

Cited by 105 publications

(70 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study expands upon previous work by showing that dementia and age affect category fluency (Auriacombe et al, 2001;Borod et al, 1980;Crossley et al, 1997;Parkin et al, 1995;Peraita et al, 2000;Tomer and Levin, 1993;Whelihan and Lesher, 1985;Wiederholt et al, 1993) and that these variables differentially affect the 14 fluency subcategories. In particular, the performance differences appeared to be constant in AD patients, elderly and young healthy controls across all nonliving subcategories, regardless of the absolute level of performance in any one subcategory.…”

Section: Discussionsupporting

confidence: 51%

“…Since our research design included two different age control groups, we were able to not only test for dementia effects, but also for the reported inverse relationship between age and category fluency (Borod et al, 1980;Parkin et al, 1995;Peraita et al, 2000;Tomer and Levin, 1993;Whelihan and Lesher, 1985), including studies on large populations (Auriacombe et al, 2001;Crossley et al, 1997;Wiederholt et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease

Moreno-Martínez¹,

Laws

Schulz

2008

Cortex

View full text Add to dashboard Cite

AgingCategory specific Semantics Sex differences APOE a b s t r a c t A category specific effect in naming tasks has been reported in patients with Alzheimer's dementia. Nonetheless, naming tasks are frequently affected by methodological problems, e.g. ceiling effects for controls and ''nuisance variables'' that may confound results.Semantic fluency tasks could help to address some of these methodological difficulties, because they are not prone to producing ceiling effects and are less influenced by nuisance variables. One hundred and thirty-three participants (61 patients with probable AD; and 72 controls: 36 young and 36 elderly) were evaluated with semantic fluency tasks in 14 semantic categories. Category fluency was affected both by dementia and by age: while in nonliving-thing categories there were differences among the three groups, in living thing categories larger lexical categories produced bigger differences among groups. Sex differences in fluency emerged, but these were moderated both by age and by pathology. In particular, fluency was smaller in female than male Alzheimer patients for almost every subcategory.

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 99%

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease

Moreno-Martínez¹,

Laws

Schulz

2008

Cortex

View full text Add to dashboard Cite

show abstract

“…Normal controls also experienced a signifi cant decline in verbal fl uency between T8 and T10; however, its magnitude was lesser than for AD subjects. This decline may be related to age: category fl uency has been shown to be sensitive to aging processes in several studies [21][22][23][24] , including studies on large samples [25,26] .…”

Section: Discussionmentioning

confidence: 99%

A Longitudinal Study of Quantitative and Qualitative Features of Category Verbal Fluency in Incident Alzheimer’s Disease Subjects: Results from the PAQUID Study

Auriacombe

Lechevallier

Amieva

et al. 2006

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

Category fluency tests were administered at baseline and after 3 and 5 years on two subgroups of subjects from a population-based cohort of elderly subjects: 52 cases of incident possible and probable Alzheimer’s disease (AD) and 104 age- and education-matched subjects who remained nondemented. Quantitative and qualitative features of category fluency were assessed to determine how changes occur within 5 years of the diagnosis of AD. Consistent with previous results, we found that the number of words produced on this task was already significantly lower 5 years before the diagnosis in subjects with incident AD as compared with subjects who did not become demented. However, the rate of repetitions only significantly increased in AD subjects at the time of diagnosis, and the rate of intrusions remained low and not significantly different between the two groups. Thus, it is concluded that dysfunction in cognitive processes underlying repetitions and intrusions in verbal fluency tasks, such as inhibitory processes and working memory, may not be the main cause of the very early deficit in verbal fluency occurring in AD.

show abstract

“…MMSE scores were classified into four groups: high normal (28)(29)(30), low normal (24-27), mildly to moderately impaired (17)(18)(19)(20)(21)(22)(23), and severely impaired (0-17). BDS scores were classified as normal (15)(16)(17)(18)(19), mildly impaired (11)(12)(13)(14), moderately impaired (7-10), and severely impaired (0-6). Twenty-four persons (1.8%) had high MMSE scores (28-30) but were impaired on the BDS.…”

Section: Relationship Of Executive Impairment To Overall Mental Statusmentioning

confidence: 99%

Prevalence of Disorders of Executive Cognitive Functioning among the Elderly: Findings from the San Luis Valley Health and Aging Study

et al. 2002

View full text Add to dashboard Cite

The San Luis Valley Health and Aging Study is a population-based epidemiologic study of chronic illness and disability among Hispanic and non-Hispanic white persons over the age of 60 in two counties in rural southern Colorado, USA. Between 1993 and 1995, we examined the prevalence of impaired executive cognitive functioning in a sample of 1,313 individuals living both in the community and in nursing homes. Overall, 1 person in 3 was found to have at least mild impairment, while 1 in 6 had moderate to severe deficits. Increasing levels of executive functioning impairment were associated with lower education, advancing age, and Hispanic ethnicity. After controlling for education and acculturation, the differences by ethnic group were no longer significant.

show abstract

Neuropsychological changes in frontal functions with aging

Cited by 105 publications

References 13 publications

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease

The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease

A Longitudinal Study of Quantitative and Qualitative Features of Category Verbal Fluency in Incident Alzheimer’s Disease Subjects: Results from the PAQUID Study

Prevalence of Disorders of Executive Cognitive Functioning among the Elderly: Findings from the San Luis Valley Health and Aging Study

Contact Info

Product

Resources

About