Neuropsychological comparisons of cocaine versus methamphetamine users: A research synthesis and meta-analysis

Hall, Matthew; Hauson, Alexander O; Wollman, Scott C; Allen, Kenneth E.; Connors, Eric J; Stern, Mark J.; Kimmel, Christine L; Stephan, Rick A.; Sarkissians, Sharis; Barlet, Brianna D; Grant, Igor

doi:10.1080/00952990.2017.1355919

Cited by 26 publications

(10 citation statements)

References 140 publications

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“…On the other hand, riluzole reduced amphetamine-induced locomotion (da Silva et al, 2003) and conditioned place preference (Tzschentke and Schmidt, 1998) in rats and showed a differential effect for cocaine and methamphetamine favoring its blocking effect on the acute response to methamphetamine (Itzhak and Martin, 2000). It is noteworthy that recent comprehensive reviews and original studies have demonstrated differences between cocaine and methamphetamine in neurotransmitter alterations (Ashok et al, 2017), neuropsychological effects (Hall et al, 2018), and neurobiological response to treatments (Johnson et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Riluzole for treatment of men with methamphetamine dependence: A randomized, double-blind, placebo-controlled clinical trial

et al. 2018

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Background: Riluzole is a glutamate regulator and effective in treatment of neuropsychiatric conditions. Aims: We assessed riluzole for treatment of methamphetamine dependence. Methods: In this randomized, double-blind, placebo-controlled clinical trial, male outpatients with methamphetamine dependence who were 18–65 years old received either 50 mg riluzole (n=34) or placebo (n=54) twice daily for 12 weeks. Patients were excluded in case of comorbid serious medical conditions or neurologic disorders, comorbid psychiatric disorders other than methamphetamine dependence requiring specific treatment interventions, simultaneous positive urine test result for substances of abuse other than methamphetamine, smoking >3 days per week, simultaneous consumption of medications which are contraindicated or have interaction with riluzole. Results: Concerning primary outcomes, the cumulative mean number of attended weekly visits was higher in the riluzole arm compared with the placebo arm approaching a statistically significant difference (riluzole, median (range)=13.00 (2.00–13.00); placebo=4.00 (2.00–13.00); Mann-Whitney U=505.00, p-value=0.073), and the weekly measured rate of positive methamphetamine urine test results was significantly lower in the riluzole arm by the end of the study (riluzole=1 (5.00%), placebo=9 (45.00%), p-value=0.004). Patients in the riluzole arm experienced significantly greater improvement on all the craving, withdrawal, and depression measures regarding mean score changes from baseline to endpoint. No significant difference was detected between the two arms in terms of incidence of adverse events. Conclusion: Future randomized clinical trials are needed to investigate proper dosing strategy in a more inclusive sample.

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Section: Introductionmentioning

confidence: 99%

Riluzole for treatment of men with methamphetamine dependence: A randomized, double-blind, placebo-controlled clinical trial

et al. 2018

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“…The CUD has also been related to executive dysfunctions that compromise efforts to initiate or maintain abstinence and affects the functionality and therapeutic effectiveness of patients 46 , 47 . Regarding the relationship between gender and educational level, women and men with low educational level started cocaine use much earlier than those with secondary studies.…”

Section: Discussionmentioning

confidence: 99%

Influence of gender and education on cocaine users in an outpatient cohort in Spain

Requena-Ocaña

Flores-López

Martín

et al. 2021

Sci Rep

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Gender significantly influences sociodemographic, medical, psychiatric and addiction variables in cocaine outpatients. Educational level may be a protective factor showing less severe addictive disorders, longer abstinence periods, and better cognitive performance. The aim was to estimate gender-based differences and the influence of educational level on the clinical variables associated with cocaine use disorder (CUD). A total of 300 cocaine-consuming patients undergoing treatments were recruited and assessed using the Psychiatric Research Interview for Substance and Mental Diseases according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision. Women developed CUD later but exhibited more consumption of anxiolytics, prevalence of anxiety disorders, eating disorders, and major depressive disorders. Alcohol and cannabis use disorders were more frequent in men. A predictive model was created and identified three psychiatric variables with good prognosis for distinguishing between women and men. Principal component analysis helped to describe the different profile types of men and women who had sought treatment. Low educational levels seemed to be a risk factor for the onset, development, and duration of CUD in both genders. Women and men exhibited different clinical characteristics that should be taken into account when designing therapeutic policies. The educational level plays a protective/risk role in the onset, development and progression of CUD, thus prolonging the years of compulsory education and implementing cognitive rehabilitation programmes could be useful.

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“…Since many other insults, including exposure to other substances, can alter BBB permeability, would additive physical damage of the BBB be always expected? This is not necessarily true, as METH has been shown to exert particular effects on the CNS, structurally and molecularly, even when compared to other related stimulants such as cocaine [106][107][108].…”

Section: S El Hayek Et Almentioning

confidence: 99%

Traumatic brain injury and methamphetamine: A double-hit neurological insult

Hayek

Allouch²,

Razafsha

et al. 2020

Journal of the Neurological Sciences

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Neuropsychological comparisons of cocaine versus methamphetamine users: A research synthesis and meta-analysis

Cited by 26 publications

References 140 publications

Riluzole for treatment of men with methamphetamine dependence: A randomized, double-blind, placebo-controlled clinical trial

Riluzole for treatment of men with methamphetamine dependence: A randomized, double-blind, placebo-controlled clinical trial

Influence of gender and education on cocaine users in an outpatient cohort in Spain

Traumatic brain injury and methamphetamine: A double-hit neurological insult

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