Neuropsychological correlates of apathy and depression in patients with dementia

Kuzis, G.; Sabe, Liliana; Tiberti, C.; Dorrego, Flavia; Starkstein, Sergio E.

doi:10.1212/wnl.52.7.1403

Cited by 143 publications

(156 citation statements)

References 20 publications

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“…These results suggested that, independently from clinical diagnosis, apathetic patients showed relevant executive impairments, in line with most previous studies [14,15,20,21,23,25,26]. In other terms, the present data indicated a strong association between apathy and alterations of cognitive functions mediated by prefrontal cortex, since apathetic and non-apathetic patients were matched for age, educational level and severity of general cognitive decline.…”

Section: Discussionsupporting

confidence: 92%

“…Apathy has also been observed in Alzheimer's disease (AD) since its early stages [24], and is associated with low functional autonomy, severe executive dysfunction and fast cognitive and functional decline [24][25][26][27]. Brain imaging studies in AD reported a significant association between apathy and abnormal perfusion in the frontal cortex and in the cingulate area [28][29][30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

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Apathy and Related Executive Syndromes in Dementia Associated with Parkinson’s Disease and in Alzheimer’s Disease

Grossi

Santangelo

Barbarulo

et al. 2013

Behavioural Neurology

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Abstract. Apathy is defined as a lack of motivation and has been reported to be common in Alzheimer's disease (AD) and Parkinson's disease (PD). To explore the neuropsychological correlates of apathy in patients with PD related dementia (PDD) and AD and to identify the specific cognitive profile of apathy in the two forms of neurodegenerative disease, 61 non-depressed patients (29 PDD and 32 AD) were selected. Out of these, 29 patients (47.5%) were detected as apathetic (14 PDD-A+ and 15 AD-A+), and 32 patients as non-apathetic (15 PDD-A-and 17 AD-A-). All patients underwent cognitive tasks tapping memory, visuospatial and executive functions, behavioral rating scales and Clinical Judgment for Apathy Syndrome (CJ-AS), an inventory developed to measure severity of apathy. The four subgroups differed significantly on memory and frontal tasks. The PDD-A+ performed significantly worse than PDD-Aon frontal tasks. The AD-A+ had poorer performance than AD-A-on frontal tasks. Last, PDD-A+ achieved significantly higher scores than AD-A+ on memory tasks. The four groups differed significantly on CJ-AS and behavioral rating scales. The results showed that apathetic patients with both forms of dementia showed a common neuropsychological and behavioral picture, characterized by defects on frontal tasks, thus strongly supporting the existence of an 'apathetic syndrome', characterized by specific cognitive and psychological symptoms.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Apathy and Related Executive Syndromes in Dementia Associated with Parkinson’s Disease and in Alzheimer’s Disease

Grossi

Santangelo

Barbarulo

et al. 2013

Behavioural Neurology

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“…Furthermore, the authors speculated that apathy might contribute directly to cognitive dysfunction in stroke patients. Our study showed that apathetic patients were more depressed; however, previous studies suggested that apathy and depression may be distinct but partially overlapping symptoms [6,9,14,36,37,38]. …”

Section: Discussioncontrasting

confidence: 80%

“…Since depression is also a common neuropsychiatric consequence of stroke, apathy and depression partially overlap in the clinical symptoms. However, apathy is an independent syndrome, distinct from depression [6,7,8]. …”

Section: Introductionmentioning

confidence: 99%

Post-Stroke Apathy and Hypoperfusion in Basal Ganglia: SPECT Study

Onoda

Kuroda²,

Yamämoto³

et al. 2010

Cerebrovasc Dis

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Background: Although apathy has been reported as one of the neuropsychiatric symptoms following stroke, there are few studies on regional cerebral blood flow (rCBF) in stroke patients with apathy. The present study compared rCBF between apathetic and non-apathetic patients after stroke. Methods: We recruited 102 patients with cerebral infarction within 1 month after stroke and performed neuropsychiatric assessments that included the apathy scale. rCBF was quantitatively measured using N-isopropyl-p-¹²³I-iodoamphetamine single-photon emission computed tomography. Results: Thirty-seven patients (36%) had apathy. The apathetic group showed lower cognitive function and a higher depressive state than the non-apathetic group. rCBF in the basal ganglia was reduced for the apathetic group compared with the non-apathetic group. Furthermore, lesions in the left basal ganglia were associated with hypoperfusion in bilateral basal ganglia and the presence of apathy. Conclusion: These findings demonstrate that apathy is a frequent symptom among stroke patients and that hypoperfusion caused by basal ganglia lesions may contribute to post-stroke apathy.

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“…Interestingly, although attentional shift was initially worse in the apathy group, this difference was no longer evident once the co-variates were accounted for. These findings are supported by studies of cognitive impairment in AD and MCI, which have also found significantly worse word list learning, verbal fluency, set shifting and naming in those with apathy compared to those without apathy (Kuzis et al, 1999;Sperry et al, 2001;Robert et al, 2006b;McPherson et al, 2002;Pluck and Brown, 2002;Starkstein et al, 1992).…”

Section: Impact Of Apathy On Cognitive Function In Pdmentioning

confidence: 70%

The Negative Impact of Apathy in Parkinson’s Disease

Leroi¹

2011

Symptoms of Parkinson's Disease

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Neuropsychological correlates of apathy and depression in patients with dementia

Abstract: Apathy, but not depression, is associated with significantly more severe frontal lobe related cognitive deficits in AD.

Cited by 143 publications

References 20 publications

Apathy and Related Executive Syndromes in Dementia Associated with Parkinson’s Disease and in Alzheimer’s Disease

Apathy and Related Executive Syndromes in Dementia Associated with Parkinson’s Disease and in Alzheimer’s Disease

Post-Stroke Apathy and Hypoperfusion in Basal Ganglia: SPECT Study

The Negative Impact of Apathy in Parkinson’s Disease

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