Neuropsychological deficits after bithalamic hemorrhages

Kuljić-Obradović, Dragana; Labudovic, G.; Basurovic, N.; Savić, Marija

doi:10.1016/j.jns.2007.01.042

Cited by 12 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The remaining 9 articles are from outside Asia: 1 from Serbia in Europe [21], 6 from the USA [1,5,6,7,43,44], and 1 each from Cuba in the Caribbean [45] and Argentina in South America [33]. …”

Section: Resultsmentioning

confidence: 99%

Primary Multiple Simultaneous Intracerebral Hemorrhages between 1950 and 2013: Analysis of Data on Age, Sex and Outcome

Laiwattana

Sangsawang

2014

Cerebrovasc Dis Extra

View full text Add to dashboard Cite

Background: Primary multiple simultaneous intracerebral hemorrhages (MSICHs) are quite rare. Although occasional reports have been found, there have been no systematic reviews. The published case reports and case series contain overlapping data, leading to erroneous information about MSICHs. This is the first extensive review of accessible studies published in English on MSICHs. Our primary objective was to analyze the demographic data on age, sex, outcome and prognosis with regard to primary MSICHs. Summary: A PubMed search without language restriction for articles with results from human studies and registered between January 1950 and September 2013 yielded 677 articles. The following inclusion criteria were applied: (1) reported case(s) or case series on primary MSICHs; (2) text partly or fully in English, and (3) text contains identifiable data on age, sex and outcome of patients. A total of 24 articles met all the inclusion criteria. The reference lists of these 24 articles were inspected for additional relevant articles, which yielded another 20 articles. In all, 248 cases were identified; 143 cases were excluded for various reasons: 52 duplicate cases, 18 cases of multiple nonsimultaneous intracerebral hemorrhages, 25 cases of secondary MSICHs, and 48 cases with incomplete data on age, sex and outcome. The remaining 105 cases were analyzed. MSICHs were found to be more common in bilateral cases (53.33%): there were bilateral basal ganglia hemorrhages (33.33%), bilateral thalamic hemorrhages (18.10%), bilateral lobar hemorrhages (0.95%) and bilateral cerebellar hemorrhages (0.95%). Nonbilateral MSICHs were found in 46.67% of the cases. The hematomas were commonly distributed in the basal ganglia (45.83%), thalamus (30.56%) and cerebellum (10.19%). MSICHs were more frequently encountered in males (60.95%; average age: 59.13 ± 12.49 years). The average age of the female patients was higher (63.89 ± 13.11 years). Patients with primary MSICHs had a survival rate of 56.20%. There was a favorable outcome of primary MSICHs in 18.10% of all the cases, the highest proportion of which was in the nonbilateral MSICH group. The remaining 38.10% had unfavorable outcomes. Death occurred in 43.80% of all cases, the highest proportion being found in the bilateral basal ganglia hemorrhage group. Primary MSICHs share features with solitary intracerebral hemorrhage regarding age, sex, and the location and distribution of hematomas, but they have a poorer outcome (p < 0.05). Key Messages: Primary MSICHs are rare and share features with solitary intracerebral hemorrhage regarding age and the location and distribution of hematomas. Patients have a poorer prognosis but higher favorable outcome rates in case of survival. This information adds to the awareness of clinicians that higher rates of favorable outcomes can be achieved for MSICHs.

show abstract

Section: Resultsmentioning

confidence: 99%

Primary Multiple Simultaneous Intracerebral Hemorrhages between 1950 and 2013: Analysis of Data on Age, Sex and Outcome

Laiwattana

Sangsawang

2014

Cerebrovasc Dis Extra

View full text Add to dashboard Cite

show abstract

“…Many previous studies have reported memory impairment in thalamic hemorrhage, although the exact prevalence of memory impairment in patients with thalamic hemorrhage has not been reported (Choi et al, 1983; Kawahara et al, 1986; Waxman et al, 1986; Hankey and Stewart-Wynne, 1988; Kumral et al, 1995; Chen et al, 1996; Chung et al, 1996; Exner et al, 2001; Summers, 2002; Kuljic-Obradovic et al, 2007; Kalefa et al, 2008). Some of these studies have reported correlation of memory impairment with the location of hematoma, in detail, posteromedial type or posterolateral type (Waxman et al, 1986; Kumral et al, 1995; Chung et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…Memory impairment is one of the various neurological manifestations in patients with thalamic hemorrhage (Choi et al, 1983; Kawahara et al, 1986; Waxman et al, 1986; Hankey and Stewart-Wynne, 1988; Kumral et al, 1995; Chen et al, 1996; Chung et al, 1996; Exner et al, 2001; Summers, 2002; Kuljic-Obradovic et al, 2007; Kalefa et al, 2008). Injury of the MTT has been suggested as one of the plausible pathogenic mechanisms of memory impairment in patients with thalamic lesions along with injury of the ventral amygdalofugal pathway and the thalamocortical pathway between the mediodorsal nucleus of the thalamus and the prefrontal cortex (Kawahara et al, 1986; Hankey and Stewart-Wynne, 1988; Graff-Radford et al, 1990; Chen et al, 1996; Exner et al, 2001; Hampstead and Koffler, 2009).…”

Section: Introductionmentioning

confidence: 99%

Injury of the Mammillothalamic Tract in Patients with Thalamic Hemorrhage

Kwon

Lee

Jang

2014

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Objective: Injury of the mammillothalamic tract (MTT) has been suggested as one of the plausible pathogenic mechanisms of memory impairment in patients with thalamic hemorrhage; however, it has not been clearly demonstrated so far. We attempted to investigate whether injury of the MTT documented by diffusion tensor tractography following thalamic hemorrhage correlates with cognitive impairment.Methods: We recruited 22 patients with a thalamic hemorrhage and 20 control subjects. MTTs were reconstructed using the probabilistic tractography method. Patients were classified into two subgroups: reconstructed group, patients whose MTT was reconstructed in the affected hemisphere, and non-reconstructed group, patients whose MTT was not reconstructed.Results: Mammillothalamic tract was reconstructed in 5 (22.7%, reconstructed group) patients in the affected hemisphere and was not reconstructed in the remaining 17 patients (77.3%, non-reconstructed group). In addition, the MTT was not reconstructed even in the unaffected hemisphere in four patients (23.5%) in non-reconstructed group. Fractional anisotropy and mean diffusivity values of the affected hemisphere in reconstructed group also did not show significant differences from those in the unaffected hemisphere of reconstructed group and the control group (p > 0.05). However, the tract volume of the affected hemisphere in reconstructed group was significantly lower than that of the unaffected hemisphere in reconstructed group and the control group (p < 0.05).Conclusion: A large portion of patients with thalamic hemorrhage appeared to suffer severe injury of the ipsilesional MTT (77.3%) and 18.2% of them appeared to suffer severe injury even in the contralesional MTT. In addition, the remaining 22.7% of patients who had preserved integrity of the ipsilesional MTT appeared to suffer partial injury of the ipsilesional MTT.

show abstract

“…Several cognitive deficits in this patient could be ascribed to bilateral medial thalamic involvement, the most prominent and persistent of which was anterograde amnesia, due to involvement of the paramedian and dorsomedial thalamus. Aphasia or anomia, lack of spontaneity ("asthenia" or abulia), perseveration, and poor attention are attributable to disruption of cortical-subcortical circuits [3,4]. Inferomedial lesions can cause gaze palsies and dystonia.…”

Section: Discussionmentioning

confidence: 99%