Neuropsychological deficits in essential tremor: an expression of cerebello‐thalamo‐cortical pathophysiology?

Tröster, Alexander I.; Woods, Steven Paul; Fields, Julie A.; Lyons, Kelly E.; Pahwa, Rajesh; Higginson, Christopher I.; Koller, William C.

doi:10.1046/j.1468-1331.2002.00341.x

Cited by 183 publications

(189 citation statements)

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“…20 A variety of non-motor features, including cognitive and psychiatric, are now appreciated and undergoing further scientific scrutiny in case-control studies. While mild problems in cognition in excess of aging have been reported in many case-control studies, [6][7][8] there have been few attempts to examine whether these cognitive problems are more considerable.…”

Section: Cross-sectional Analyses (Baseline Data)mentioning

confidence: 99%

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Essential tremor is associated with dementia

2009

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Section: Cross-sectional Analyses (Baseline Data)mentioning

confidence: 99%

“…[3][4][5] In a growing number of studies, mild cognitive problems are being observed in ET cases. [6][7][8] Furthermore, an association between ET and dementia was reported in a recent population-based study in central Spain. 9,10 This novel association has yet to be verified in other populations.…”

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confidence: 99%

Essential tremor is associated with dementia

2009

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“…Mild cognitive deficits have been reported to occur in patients with essential tremor (ET) in many independent studies, [1][2][3][4][5][6][7][8] including a population-based study of largely treatment-naive ET patients (Neurological Disorders in Central Spain [NEDICES] study). 8 These studies suggest that a frontosubcortical-type dysfunction occurs in some patients with ET.…”

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confidence: 99%

Rate of cognitive decline during the premotor phase of essential tremor

et al. 2013

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Objective: To characterize the rate of cognitive decline during the premotor phase of essential tremor (ET) in comparison to prevalent ET cases and controls.Methods: In this population-based, prospective study of people aged 65 years and older (Neurological Disorders in Central Spain), a 37-item version of the Mini-Mental State Examination was administered at 2 visits (baseline and follow-up, approximately 3 years later). We compared the rate of cognitive decline in 3 groups: prevalent ET cases (i.e., participants diagnosed with ET at baseline and at follow-up), "premotor" ET cases (i.e., participants diagnosed with incident ET at follow-up, but not at baseline), and controls (i.e., participants not diagnosed with ET at baseline or follow-up).Results: The 2,375 participants included 135 prevalent ET cases, 56 premotor ET cases, and 2,184 controls. During the follow-up period of 3.4 6 0.5 years (mean 6 SD), the 37-item version of the Mini-Mental State Examination declined by 0.7 6 3.3 points (0.2 6 1.0 points/year) in prevalent ET cases, 1.1 6 3.5 points (0.3 6 1.0 points/year) in premotor ET cases, and 0.1 6 3.9 points (0.0 6 1.2 points/year) in controls (p 5 0.014). The difference between premotor ET cases and controls was significant (p 5 0.046), as was the difference between prevalent ET cases and controls (p 5 0.027). Conclusions:In this prospective cohort, cognitive test scores in premotor and prevalent ET cases declined at a faster rate than in elders without this disease. A decline in global cognitive function may occur in a premotor phase of ET. Mild cognitive deficits have been reported to occur in patients with essential tremor (ET) in many independent studies, 1-8 including a population-based study of largely treatment-naive ET patients (Neurological Disorders in Central Spain [NEDICES] study).8 These studies suggest that a frontosubcortical-type dysfunction occurs in some patients with ET. [9][10][11][12][13][14] In the NEDICES study, lower cognitive test scores were associated with more reported functional difficulty, indicating a clinical-functional correlate. 15 The NEDICES study provided evidence that cognitive deficits in ET are not static, and appear to be progressing at a faster rate than in elders without this disease. 16 There could be a "premotor" stage of ET, as there is in other adultonset and late-life motor disorders. However, population-based studies that prospectively assess whether cognitive dysfunction appears in premotor ET (i.e., those subjects who were free of ET at baseline but who developed ET during the follow-up) have not been conducted.We hypothesized that the cognitive deficits in premotor and prevalent ET would not be static, but would deteriorate, and that this deterioration would occur at a rate above that observed in similarly aged controls. Using data from the NEDICES study, we evaluated ET

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“…Studies on this subject showed cognitive impairment with affected visuospatial abilities, verbal memory, executive functions, verbal fluency, naming and working memory in ET (12,33,34,35,36). Moreover, in a limited number of studies conducted with young patients, this condition has been proved to be present even at early stages (6,13).…”

Section: Discussionmentioning

confidence: 86%

“…In several studies, findings suggesting cerebral-thalamocortical tract dysfunction were found in patients with ET. Mild cognitive impairment characterized by impairment of visuospatial functions, verbal memory, and executive functions has been shown in young patients (8,9,10,11,12,13).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: A Comparative Study

Şengül¹,

Şengül²,

Yücel³

et al. 2016

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Objective: In multiple sclerosis (MS); memory, attention, information processing speed, and executive function deficits associated with cortical demyelination and atrophy can be seen in the early phases. In essential tremor (ET) cognitive impairment associated with cerebral-thalamocortical pathway dysfunction, which is characterized by visuospatial functions, verbal memory, and executive functions were seen. We aimed to evaluate cognitive impairment in patients with MS and ET, and to compare the features of impairment. Materials and Methods:Thirty patients ET (mean age 27.7±6.8 years), 30 patients with MS (mean age 32.4±6.6 years) and 20 healthy controls (mean age 28.81±7.3 years) were recruited for the study. For assessing cognitive impairment, the Montreal Cognitive Assessment (MoCA) test was applied to all participants. For grading the disease, the Fahn-Tolosa-Marin Tremor Rating Scale was used in the ET group, and the Expanded Disability Status Scale was used in the MS group. Results:The total MoCA mean scores in patients with MS was 22.4±4.34, 25.8±2.7 in patients with ET, and 28.2±1.8 in controls. When we compared the patients with the controls, the patients' mean score was lower than in the controls. Cognitive impairment in patients with MS was more apparent than in patients with ET. Naming, attention, language, and delayed recall subgroups in patients with MS were more affected than in patients with ET. Conclusion:In this present study, we determined cognitive impairment can be seen in both group of patients, and MS can cause more prominent deficit than ET. In addition, our study confirms that cognitive impairment in MS and ET can be detected using the MoCA test. Keywords: Multiple sclerosis, essential tremor, cognitive impairment, Montreal Cognitive Assessment testAmaç: Multipl sklerozda (MS) kortikal demiyelinizasyon ve atrofi ile ilişkili bellek, dikkat, bilgi işleme hızı ve yönetici işlev bozuklukları hastalığın ilk dönemlerinden itibaren görülmektedir. Esansiyel tremorda (ET) ise serebello-talamo-kortikal yol disfonksiyonunu ile viziospasyal fonksiyonlar, verbal hafıza ve yine yürütücü işlevlerin bozulması ile karakterize kognitif etkilenmenin olduğu gösterilmiştir. Çalışmamızda MS ve ET hastalarında kognitif bozukluğunun değerlendirilmesini ve özellikleri açısından karşılaştırılmasını amaçladık. Gereç ve

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Neuropsychological deficits in essential tremor: an expression of cerebello‐thalamo‐cortical pathophysiology?

Cited by 183 publications

References 43 publications

Essential tremor is associated with dementia

Essential tremor is associated with dementia

Rate of cognitive decline during the premotor phase of essential tremor

Cognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: A Comparative Study

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