Neuropsychological development in a child with early-treated congenital hypothyroidism as compared with her unaffected identical twin

Abstract

Because the twins were genetically and phenotypically identical, were raised in the same environment, and received a similar education, it is concluded that hypothyroidism in utero and in the first neonatal month was responsible for the lower neuropsychological achievements of the CH twin. While foetal hypothyroidism is at present unavoidable, earlier diagnosis and initiation of treatment in neonates with CH are important and highly recommended.

School attainments in children with congenital hypothyroidism detected by neonatal screening and treated early in life

“…Although in our (18,40) and others' (14,15,17,41,42) experience, a low neonatal T 4 level is a risk factor for a defective neuropsychological development, in the present study the degree of neonatal thyroid hormone deficiency was not found to be a major variable influencing school learning. In this regard, our results do not completely agree with the recent observation that a low neonatal T 4 is associated with less satisfactory scores for educational attainments (21).…”

“…In some follow-up programmes for CH, global IQs of children treated early in life do not differ from those of control children (1, 3). Other follow-up studies report a mild decrease in global IQs compared with controls (10)(11)(12)(13)(14)(15)(16)(17)(18). Differences in motor and psychometric subtests have also been reported.…”

“…However, some of these CH children have subtle impairments in language abilities (3)(4)(5), neuromotor skills (5-7), behaviour (8,9) and cognitive performances (4,(10)(11)(12)(13)(14)(15)(16)(17)(18). Such impairments might adversely affect school learning.…”

Alterações fonoaudiológicas em crianças com hipotireoidismo congênito: revisão crítica da literatura

“…The results showed from the three Speechlanguage Pathology fields investigated, language was the one with higher number of published papers [16][17][18][19][20][21][22][23][24][25][26] . This allows the arguing about this topic in CH children to be more clear and consistent, but do not exclude the importance of other communication aspects.…”

“…Subtitles: SG= study group; CG = control group Figure 2 -Contents of localized papers about speech-language disturbances related to congenital hypothyroidism significant delay in language development [17][18][19][20][22][23][24]26 .…”