Neuropsychological Disorders in Children Exposed to Alcohol during Pregnancy: A Follow‐Up Study of 24 Children to Alcoholic Mothers in Göteborg, Sweden

Aronson, Marita; Hagberg, Bibbi

doi:10.1111/j.1530-0277.1998.tb03655.x

Cited by 57 publications

(44 citation statements)

References 10 publications

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“…[17][18][19][20][21][22][23][24][25] Together they constituted this study group consisting of 79 individuals (63% men) with an FAS diagnosis, 1,29 which required (1) a documented history of alcohol abuse during pregnancy, (2) a characteristic pattern of facial anomalies, (3) growth retardation, and (4) neurodevelopmental abnormalities of the central nervous system. The FAS group was followed up in national registers in 2011 when they had a mean age of 32 years (18- …”

Section: Study Populationsmentioning

confidence: 99%

“…Based on these studies, [17][18][19][20][21][22][23][24][25] and others, 6,10,11,14,16 we expected that the FAS group would have experienced more problems in school, limited career options, mental illness, alcohol abuse, use of illicit drugs, and trouble with the law than majority population peers. Therefore, this record-linkage study investigated possible secondary disabilities focused on outcome variables like these among the study cohort and compared them with a population matched by age, gender, and location.…”

mentioning

confidence: 99%

“…The participants in this follow-up study consisted of 79 adults with a verified FAS diagnosis; some of them participated in previous studies [17][18][19][20][21][22][23][24][25] on physical and psychosocial development. Based on these studies, [17][18][19][20][21][22][23][24][25] and others, 6,10,11,14,16 we expected that the FAS group would have experienced more problems in school, limited career options, mental illness, alcohol abuse, use of illicit drugs, and trouble with the law than majority population peers.…”

mentioning

confidence: 99%

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Psychosocial Outcomes of Fetal Alcohol Syndrome in Adulthood

Rangmar¹,

Hjern

Vinnerljung

et al. 2015

Pediatrics

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BACKGROUND AND OBJECTIVE: Primary disabilities in children prenatally exposed to alcohol have a major impact on their daily life. It is suggested that these issues persist into adulthood, but few studies have addressed the outcome in adults with prenatal exposure, especially those with fetal alcohol syndrome (FAS). The aim of this follow-up study was to investigate outcome variables, such as education, employment, health, and criminal acts, in 79 adults diagnosed with FAS. METHODS:We carried out a national register-based study of 79 adults with an FAS diagnosis, at a mean age of 32. Education, social adjustment, and mental health outcomes were analyzed and compared with 3160 comparison individuals matched on age, gender, and place of birth. RESULTS:The FAS group was much more likely to have received special education (25% vs 2%), be unemployed (51% vs 15%), and receive a disability pension (31% vs 3%) than the comparisons, but the levels of criminal offenses were similar. The FAS group had higher hospital admission rates for alcohol abuse (9% vs 2%) and psychiatric disorders (33% vs 5%) and was more likely to be prescribed psychotropic drugs (57% vs 27%).CONCLUSIONS: Swedish children with FAS have quite diverse psychosocial outcomes in adulthood, considerably worse than for majority population peers. Potential risk and protective factors within the FAS group deserve study to enable development of effective interventions. WHAT'S KNOWN ON THIS SUBJECT:Prenatal alcohol exposure can cause congenital neuropsychological and behavioral disabilities in later life. These usually lead to secondary disabilities (adverse outcome when the individual interacts with environmental settings), such as problems with school, the law, alcohol, or drugs. WHAT THIS STUDY ADDS:This was a 30-year psychosocial register-based follow-up on adults with fetal alcohol syndrome and state care comparison group. The FAS-group had lower education and higher rates of unemployment, social welfare, and mental health problems than peers. Rates of criminality did not differ.

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Section: Study Populationsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Psychosocial Outcomes of Fetal Alcohol Syndrome in Adulthood

Rangmar¹,

Hjern

Vinnerljung

et al. 2015

Pediatrics

Self Cite

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“…The damage is caused by the mother's high alcohol consumption. The brain damage gives behavioural disturbances and severe learning problems while the child is growing up, and the severity of symptoms depends on the quantities of alcohol to which the child was exposed while a foetus [23].…”

Section: Pregnancy and Living Habitsmentioning

confidence: 99%

Chapter 6: Reproductive health

Danielsson

Sundström²

2006

Scand J Public Health

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“…The teratogenicity of alcohol has been established by a vast experimental animal literature (25)(26)(27)(28) (7,23,38), and a wide variety of behavioral problems (39)(40)(41)(42). Figure 3 represents the combined FAS/FAE distributions for three of the most common types of psychological tests all scaled to a standard deviation of 15 (16)].…”

Section: Categorizing Fas and Screening For Prenatal Effects Of Alcohmentioning

confidence: 99%

On Categorizations in Analyses of Alcohol Teratogenesis

Sampson¹,

Streissguth²,

Bookstein³

et al. 2000

Environmental Health Perspectives

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In biomedical scientific investigations, expositions of findings are conceptually simplest when they comprise comparisons of discrete groups of individuals or involve discrete features or characteristics of individuals. But the descriptive benefits of categorization become outweighed by their limitations in studies involving dose-response relationships, as in many teratogenic and environmental exposure studies. This article addresses a pair of categorization issues concerning the effects of prenatal alcohol exposure that have important public health consequences: the labeling of individuals as fetal alcohol syndrome (FAS) versus fetal alcohol effects (FAE) or alcoholrelated neurodevelopmental disorder (ARND), and the categorization of prenatal exposure dose by thresholds. We present data showing that patients with FAS and others with FAE do not have meaningfully different behavioral performance, standardized scores of IQ, arithmetic and adaptive behavior, or secondary disabilities. Similarly overlapping distributions on measures of executive functioning offer a basis for identifying alcohol-affected individuals in a manner that does not simply reflect IQ deficits. At the other end of the teratological continuum, we turn to the reporting of threshold effects in dose-response relationships. Here we illustrate the importance of multivariate analyses using data from the Seattle, Washington, longitudinal prospective study on alcohol and pregnancy. Relationships between many neurobehavioral outcomes and measures of prenatal alcohol exposure are monotone without threshold down to the lowest nonzero levels of exposure, a finding consistent with reports from animal studies. In sum, alcohol effects on the developing human brain appear to be a continuum without threshold when dose and behavioral effects are quantified appropriately.

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Neuropsychological Disorders in Children Exposed to Alcohol during Pregnancy: A Follow‐Up Study of 24 Children to Alcoholic Mothers in Göteborg, Sweden

Cited by 57 publications

References 10 publications

Psychosocial Outcomes of Fetal Alcohol Syndrome in Adulthood

Psychosocial Outcomes of Fetal Alcohol Syndrome in Adulthood

Chapter 6: Reproductive health

On Categorizations in Analyses of Alcohol Teratogenesis

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