Neuropsychological Effects of Low Mercury Vapor Exposure in Chloralkali Workers

Ellingsen, Dag G.; Bast‐Pettersen, Rita; Efskind, Jon; Thomassen, Yngvar

doi:10.1016/s0161-813x(01)00012-2

Cited by 55 publications

(41 citation statements)

References 24 publications

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“…Studies on current exposure of workers to mercury [57][58][59][60][61][62][63][64][65][66][67][68][69] were mostly conducted on workers in industry (chlorine-alkaline factories, thermometer factories, mercury extraction plants), and in one case on gold miners in the Philippines who use large amounts of mercury without any protection [59]. Correlations between the amount of Hg excreted in urine and measures of cognitive abilities (memory tests, attention span) were always significant and negative, i.e., the more mercury excreted the worse the test results.…”

Section: Mercury Exposure In Workersmentioning

confidence: 99%

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter¹,

Curth

Naumann³

et al. 2010

JAD

147

113

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Abstract. Mercury is one of the most toxic substances known to humans. It has been introduced into the human environment and has also been widely used in medicine. Since circumstantial evidence exists that the pathology of Alzheimer's disease (AD) might be in part caused or exacerbated by inorganic mercury, we conducted a systematic review using a comprehensive search strategy. Studies were screened according to a pre-defined protocol. Two reviewers extracted relevant data independent of each other. One thousand and forty one references were scrutinized, and 106 studies fulfilled the inclusion criteria. Most studies were case control or comparative cohort studies. Thirty-two studies, out of 40 testing memory in individuals exposed to inorganic mercury, found significant memory deficits. Some autopsy studies found increased mercury levels in brain tissues of AD patients. Measurements of mercury levels in blood, urine, hair, nails, and cerebrospinal fluid were inconsistent. In vitro models showed that inorganic mercury reproduces all pathological changes seen in AD, and in animal models inorganic mercury produced changes that are similar to those seen in AD. Its high affinity for selenium and selenoproteins suggests that inorganic mercury may promote neurodegenerative disorders via disruption of redox regulation. Inorganic mercury may play a role as a co-factor in the development of AD. It may also increase the pathological influence of other metals. Our mechanistic model describes potential causal pathways. As the single most effective public health primary preventive measure, industrial, and medical usage of mercury should be eliminated as soon as possible.

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Section: Mercury Exposure In Workersmentioning

confidence: 99%

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter¹,

Curth

Naumann³

et al. 2010

JAD

147

113

View full text Add to dashboard Cite

show abstract

“…James y col. ( 72 ) han mostrado que el timerosal induce estrés oxidativo y la apoptosis de neuronas, astrocitos y células T humanas, activando vías metabólicas mitocondriales de muerte celular. Lo anterior explica las alteraciones observadas a nivel de la estructura neuronal, que traería como consecuencia una disminución en la población de neuronas, lo cual se asocia en la clínica a trastornos en el desarrollo psicomotor, retardo del lenguaje, problemas de comportamiento, pérdida de la visión, audición, convulsiones, autismo, etc ( [94][95][96] ). Recientemente, diversas investigaciones han demostrado también que el timerosal es capaz de dañar severamente la metilación, una ruta metabólica crítica en la habilidad de los factores de crecimiento para promover el desarrollo neurológico normal ( 72,[97][98][99] ).…”

Section: Resultsunclassified

Efectos neurotóxicos del timerosal, a dosis de vacuna, sobre el encéfalo y el desarrollo en hámsteres de 7 días de nacidos

et al. 2013

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“…Pesticides: Rohlman et al 2007 Mercury: Ellingsen et al 2001;Letz et al 2000 Methylmercury: Yokoo et al 2003 Lead: Bleecker et al 2007;Dorsey et al 2006 Manganese: Bowler et al 2006;Zoni et al 2007;Hochberg et al 1996 They range from simple techniques that can be embedded in a test battery to those that require complex instrumentation.…”

Section: Motor Functionmentioning

confidence: 99%

Chemobrain: A translational challenge for neurotoxicology

Weiss

2008

NeuroToxicology

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Neurotoxicity is a frequent accompaniment of cancer chemotherapy, and held by many oncologists to be the major dose-limiting side effect. It appears in many forms, but attracted attention during the past decade primarily because of complaints by patients of impaired cognitive function they have labeled as "chemobrain". Neuropsychological testing confirmed the validity of these complaints and has generated a substantial literature examining different aspects of cognitive impairment in various clinical populations undergoing a variety of treatments. Cognitive impairment is far from the only manifestation of neurotoxicity induced by chemotherapy, however. It alters sensory function and motor function as well. A critical need for patients is a suite of methods that will enable clinicians to trace the onset and progression of neurotoxicity so as to guide and balance decisions about the course of chemotherapy. This commentary describes some of the potential methods and encourages neurotoxicologists to enlist their unique skills in the service of these needs.

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Neuropsychological Effects of Low Mercury Vapor Exposure in Chloralkali Workers

Cited by 55 publications

References 24 publications

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Efectos neurotóxicos del timerosal, a dosis de vacuna, sobre el encéfalo y el desarrollo en hámsteres de 7 días de nacidos

Chemobrain: A translational challenge for neurotoxicology

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