Neuropsychological Functioning of Youth Receiving Intensive Interdisciplinary Pain Treatment

Kapalu, Christina M. Low; Hall, John Joshua; Wallace, Dustin P.

doi:10.1093/jpepsy/jsy034

Cited by 18 publications

(21 citation statements)

References 49 publications

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“…Overall, the present study sample displayed similar demographic and pain-related characteristics to other clinical samples in pediatric chronic pain research, eg, included a majority of girls. 29 , 32 , 40 Clinically significant ASD traits were also more prevalent among girls than boys in the current sample, with 17.6% of girls presenting scores in the clinical range (as tentative comparison, the prevalence of ASD among girls in the general population is 0.53% as reported by the Centers for Disease Control and Prevention) 8 , as compared to 4.5% of the boys. This result is also interesting in the light of the ASD male:female ratio of 2.3:1 in the general population.…”

Section: Discussionsupporting

confidence: 45%

“…As comparison, a large, population-based longitudinal case-control study using the parental SRS found 6.5% of control participants (mixed gender) to be within the clinical ASD range, 78 while a recent, although comparatively small, study on youth with chronic pain in intensive interdisciplinary pain treatment found ASD in 8% and ADHD in 18% of participants. 40 Furthermore, the scores for the C3 in the current sample were clearly elevated compared to the norm average mean.…”

Section: Discussionmentioning

confidence: 62%

“…Moreover, deficits in executive function rendering social interaction and academic performance more burdensome may function as a chronic stressor for these children, which may further increase the risk for problems with health and functioning. 40 Future studies may also explore if pain may share etiological mechanisms with neurodevelopmental disorders, particularly in individuals with altered sensory processing.…”

Section: Discussionmentioning

confidence: 99%

“… 39 Recent research has shown that youths with chronic pain may show deficits in aspects of executive function and that some of these deficits, eg, difficulty with unexpected change, may, in fact, predate the onset of pain itself. 40 Moreover, psychiatric disorders, in particular, anxiety and depression, are common in pediatric chronic pain, 41 , 42 and have been associated with elevated levels of functional impairments. 36 , 43 – 45 A few clinical reports, 46 – 49 a number of studies on abdominal pain, 20 , 50 a study on migraine, 51 and a recent study on neuropsychological function in chronic pain 40 have suggested that ASD and ADHD may be comorbid to pediatric chronic pain and that such comorbid neurodevelopmental conditions may go undetected.…”

Section: Introductionmentioning

confidence: 99%

“…Importantly, however, the prevalence of these disorders, including clinically significant traits, in pediatric patients with chronic pain is still unclear. 40 …”

Section: Introductionmentioning

confidence: 99%

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Prevalence of autism traits and attention-deficit hyperactivity disorder symptoms in a clinical sample of children and adolescents with chronic pain

Lipsker

Bölte

Hirvikoski

et al. 2018

JPR

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PurposeRecent research has suggested that autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) may be comorbid to pediatric chronic pain, but the empirical support is yet scarce. Therefore, the current study aimed to investigate the occurrence of traits and symptoms consistent with clinically significant ASD and ADHD in a group of children and adolescents with chronic debilitating pain and examine potential differences in pain and demographic variables between children with and without clinically significant traits and symptoms of ASD and ADHD.Patients and methodsThis cross-sectional study included 146 parent–child dyads (102 girls, 111 mothers, children 8–17 years) consecutively referred to a tertiary pain clinic. Parents completed the Social Responsiveness Scale to assess autistic traits, and Conners-3 to measure symptoms of ADHD in their children. Children completed the Lübeck Pain Questionnaire to evaluate experienced pain.ResultsAmong children, 20 (13.7%) received scores consistent with clinically significant ASD and 29 (19.9%) received scores consistent with clinically significant ADHD, with a combined prevalence of clinically significant ASD/ADHD traits and symptoms of 26% of the total sample. Only 4.8% of children were previously diagnosed with either disorder. Among children with clinically significant ASD traits, girls were more prevalent, parents reported lower health, and the pain was more likely triggered by being in school. Among children with clinically significant ADHD symptoms, there were no gender differences and pain was more likely triggered by the family situation and new situations. No differences regarding pain intensity, duration, or frequency were found between children with and without clinically significant ASD traits or ADHD symptoms.ConclusionChildren with debilitating chronic pain, particularly girls, may present with an elevated risk of having a comorbid, possibly high-functioning, neurodevelopmental disorder. Results suggest that clinical assessment of pediatric chronic pain should include screening for neurodevelopmental disorders.

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Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Importantly, however, the prevalence of these disorders, including clinically significant traits, in pediatric patients with chronic pain is still unclear. 40 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Prevalence of autism traits and attention-deficit hyperactivity disorder symptoms in a clinical sample of children and adolescents with chronic pain

Lipsker

Bölte

Hirvikoski

et al. 2018

JPR

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A Systematic Review of the Validity and Reliability of Assessment Tools for Executive Function and Adaptive Function Following Brain Pathology among Children and Adolescents in Low- and Middle-Income Countries

Kusi-Mensah

Nuamah²,

Wemakor

et al. 2022

Neuropsychol Rev

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Minimal but increasing number of assessment instruments for Executive functions (EFs) and adaptive functioning (AF) have either been developed for or adapted and validated for use among children in low and middle income countries (LAMICs). However, the suitability of these tools for this context is unclear. A systematic review of such instruments was thus undertaken. The Systematic review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) checklist (Liberati et al., in BMJ (Clinical Research Ed.), 339, 2009). A search was made for primary research papers reporting psychometric properties for development or adaptation of either EF or AF tools among children in LAMICs, with no date or language restrictions. 14 bibliographic databases were searched, including grey literature. Risk of bias assessment was done following the COSMIN (COnsensus-based Standards for the selection of health status Measurement INstruments) guidelines (Mokkink et al., in Quality of Life Research,63, 32, 2014). For EF, the Behaviour Rating Inventory of Executive Functioning (BRIEF- multiple versions), Wisconsin Card Sorting Test (WCST), Go/No-go and the Rey-Osterrieth complex figure (ROCF) were the most rigorously validated. For AFs, the Vineland Adaptive Behaviour Scales (VABS- multiple versions) and the Child Function Impairment Rating Scale (CFIRS- first edition) were most validated. Most of these tools showed adequate internal consistency and structural validity. However, none of these tools showed acceptable quality of evidence for sufficient psychometric properties across all the measured domains, particularly so for content validity and cross-cultural validity in LAMICs. There is a great need for adequate adaptation of the most popular EF and AF instruments, or alternatively the development of purpose-made instruments for assessing children in LAMICs.Systematic Review Registration numbers: CRD42020202190 (EF tools systematic review) and CRD42020203968 (AF tools systematic review) registered on PROSPERO website (https://www.crd.york.ac.uk/prospero/).

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A developmental framework for understanding the influence of sex and gender on health: Pediatric pain as an exemplar

Boerner,

Keogh,

Inkster

et al. 2024

Neuroscience & Biobehavioral Reviews

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Neuropsychological Functioning of Youth Receiving Intensive Interdisciplinary Pain Treatment

Cited by 18 publications

References 49 publications

Prevalence of autism traits and attention-deficit hyperactivity disorder symptoms in a clinical sample of children and adolescents with chronic pain

Prevalence of autism traits and attention-deficit hyperactivity disorder symptoms in a clinical sample of children and adolescents with chronic pain

A Systematic Review of the Validity and Reliability of Assessment Tools for Executive Function and Adaptive Function Following Brain Pathology among Children and Adolescents in Low- and Middle-Income Countries

A developmental framework for understanding the influence of sex and gender on health: Pediatric pain as an exemplar

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