Neuropsychological Impairment From Acute Low-Level Exposure to Carbon Monoxide

Amitai, Yona; Zlotogorski, Zoli; Golan-Katzav, Vered; Wexler, Anya; Gross, Ditza

doi:10.1001/archneur.55.6.845

Cited by 126 publications

(85 citation statements)

References 13 publications

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“…CO leads to a decrease in PO 2 in the muscle tissue and may cause rhabdomyolysis, which may result in kidney damage. CO may cause focal necrosis and edema in some brain regions, resulting in plegia and paresia in various organs and also changes can be seen in consciousness withpsychiatric symptoms [5]. In the case presented herein, on the 4 th day of intoxication, TTP with the classical clinical pentad developed.…”

Section: Discussionmentioning

confidence: 67%

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A Very Rare Complication of Carbon Monoxide Intoxication; Thrombotic Thrombocytopenic Purpura

Turan¹

2014

Turk J Bioch

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Section: Discussionmentioning

confidence: 67%

“…At the cellular level, damage is presumably due to a combination of hypoxia and a direct toxic effect of CO on mitochondrial function [1]. While the symptoms may be headache, fatigue and nausea in mild exposures, loss of consciousness, coma and even death may ensue in severe exposures [5].…”

Section: Discussionmentioning

confidence: 99%

A Very Rare Complication of Carbon Monoxide Intoxication; Thrombotic Thrombocytopenic Purpura

Turan¹

2014

Turk J Bioch

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“…Estas alteraciones se mostraron a pesar de que el nivel de COHb en expuestos fue muy bajo (0.01 a 0.11%); resultado que habla de la vulnerabilidad del cerebro y las funciones cognitivas a cambios hipóxico-isquémicos. 21 También, de mecanismos independientes de los niveles de COHb que provocan estos cambios, como se muestra en la mejoría de pacientes que toman sesiones en terapia hiperbárica, quienes presentan niveles casi normales de COHb antes de la sesión, pero que muestran mejoría significativa en las pruebas neuropsicológicas después de la terapia.…”

Section: Discusión Y Conclusiónunclassified

Alteraciones neuropsicológicas por exposición crónica a concentraciones bajas de monóxido de carbono en trabajadores de autopista de peaje de México

Díaz-López¹,

Haro-García

Juárez-Pérez

et al. 2015

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BackgroundWorkers of the automobile industry, service stations and those working in the streets, are in chronic contact to low concentrations of carbon monoxide and at risk to damage the cardiovascular, haematology and nervous systems. ObjectiveIdentify erythrocytosis and neuropsychological alterations in highway workers chronically exposed to low concentrations of CO. MethodCross-sectional study that included 72 workers of the Mexico-Puebla Highway cabins (guards); 60 cashiers and 12 workers in charge of the shift, in which socio-demographic, clinical and occupational variables were explored; haemoglobin(Hb), hematocrit (Htc) and carboxyhemoglobin (COHb) was determined in their blood, and it was applied the Carbon monoxide neuropsychological screening battery (CONSB). The workers who are in charge of the full shift integrated the less exposed to CO group, while the cashiers would shape the greater exposure group. ResultsIn 49 workers, Hb: 18.1±1.9 mg/dL and Htc: 55.3±8.7 without significant differences between groups (p=0.82). The greater alteration was identified in the exposed group in the test of digit symbol (p= 0.012), trail-making part B (p= 0.002), and digit span (p=0.003); the test of blocks design resulted borderline (p=0.07). Discussion and conclusionThe group with the highest exposure to CO had lower performance in visual perception, encoding, visual-motor perception and immediate memory. Therefore important to consider epidemiological surveillance workers to intervene in cases with abnormal tests. The perception of innocuousness of chronic exposure to CO in these workers must avoid.Key words: Neuropsychological alterations, carboxyhemoglobin, CONSB, chronic occupational exposure, carbon monoxide. RESUMEN AntecedentesTrabajadores de la industria automovilística, estaciones de servicio, autopistas de peaje, estacionamientos y los que laboran en las calles, están en contacto crónico con bajas concentraciones de monóxido de carbono (CO) y, por lo tanto, en riesgo de sufrir alteraciones en los sistemas cardiovascular, hematológico y nervioso. ObjetivoIdentificar la relación de las alteraciones neuropsicológicas con la exposición crónica a bajas concentraciones de CO, en trabajadores de autopistas de peaje. MétodoEstudio transversal en 72 trabajadores de autopistas de peaje de la carretera México-Puebla; 60 cajeros y 12 encargados de turno. Se exploraron variables socio-demográficas, clínicas y ocupacionales, y se determinó hemoglobina (Hb), hematocrito (Htc) y carboxihemoglobina (COHb) en sangre. Se aplicaron pruebas neuropsicológicas (Carbon monoxide neuropsychological screening battery CONSB). Los encargados de turno conformaron el grupo menos expuesto y los cajeros el de mayor exposición a CO. ResultadosEn 49 trabajadores, Hb: 18.1±1.9 mg/dL y Htc: 55.3±8.7, sin diferencias significativas entre grupos (p=0.82). Se observó menor desempeño en el grupo más expuesto, en el test de dígitos y símbolos (p= 0.012), senderos B (p= 0.002) y dígitos (p=0.003). El test de construcción con bloques resultó...

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“…[7,8] Thus, exposure to CO at varying levels in the workplace produces a range of different effects from headache and lethargy to coma, seizures, and death that can interfere with an individual's working capacity. [9] Diagnosis of CO toxicity is difficult because of vague presentation of diverse symptoms. Simple device like breathalyzer can be used in suspected group of people to overcome this difficulty.…”

Section: Introductionmentioning

confidence: 99%

Analysis of breath carbon monoxide among urban automobile drivers

Chitra¹,

R²,

Meerasa³

2018

Natl J Physiol Pharm Pharmacol

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Background: Air pollution caused by automobiles can pose serious health hazard due to urbanization. Carbon monoxide (CO) is one of the six criteria for air pollution related to urbanization. Urban drivers are occupationally at risk of exposure to CO. Aims and Objectives: This study was undertaken to assess the levels of CO in breath among the exposed group of urban automobile drivers and to compare breath CO levels among various group of drivers based on their years of experience or duration of exposure. Materials and Methods: A cross-sectional analysis of breath sample for the presence of CO was conducted on automobile drivers (n = 101) using different type of motor vehicles in urban Chennai using breath CO analyzer (Vitalograph 29700). Mean CO levels were compared among groups using ANOVA. Proportion in groups was assessed by χ

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Neuropsychological Impairment From Acute Low-Level Exposure to Carbon Monoxide

Cited by 126 publications

References 13 publications

A Very Rare Complication of Carbon Monoxide Intoxication; Thrombotic Thrombocytopenic Purpura

A Very Rare Complication of Carbon Monoxide Intoxication; Thrombotic Thrombocytopenic Purpura

Alteraciones neuropsicológicas por exposición crónica a concentraciones bajas de monóxido de carbono en trabajadores de autopista de peaje de México

Analysis of breath carbon monoxide among urban automobile drivers

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