Neuropsychological outcome after deep brain stimulation for Parkinson disease

Odekerken, Vincent J.J.; Boel, Judith A.; Geurtsen, Gert J.; Schmand, Ben; Dekker, Iris; Haan, Rob J. de; Schuurman, P. Richard; Bie, Rob M.A. de

doi:10.1212/wnl.0000000000001419

Cited by 78 publications

(92 citation statements)

References 19 publications

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“…Nevertheless, it is not unusual that the beneficial effect of DBS is mitigated by various side-effects such as dysarthria, decrease in verbal fluency, and changes in behaviour, fatigue, and depression [4–6]. Careful selection criteria of patients considered for DBS have been established, including Levodopa response, age, normal brain MRI, good cognition, and realistic expectations [3, 7].…”

Section: Introductionmentioning

confidence: 99%

Are Patients Ready for “EARLYSTIM”? Attitudes towards Deep Brain Stimulation among Female and Male Patients with Moderately Advanced Parkinson’s Disease

Sperens

Hamberg

Hariz

2017

Parkinson's Disease

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Objective. To explore, in female and male patients with medically treated, moderately advanced Parkinson's disease (PD), their knowledge and reasoning about Deep Brain Stimulation (DBS). Methods. 23 patients with PD (10 women), aged 46–70, were interviewed at a mean of 8 years after diagnosis, with open-ended questions concerning their reflections and considerations about DBS. The interviews were transcribed verbatim and analysed according to the difference and similarity technique in Grounded Theory. Results. From the patients' narratives, the core category “Processing DBS: balancing symptoms, fears and hopes” was established. The patients were knowledgeable about DBS and expressed cautious and well considered attitudes towards its outcome but did not consider themselves ill enough to undergo DBS. They were aware of its potential side-effects. They considered DBS as the last option when oral medication is no longer sufficient. There was no difference between men and women in their reasoning and attitudes towards DBS. Conclusion. This study suggests that knowledge about the pros and cons of DBS exists among PD patients and that they have a cautious attitude towards DBS. Our patients did not seem to endorse an earlier implementation of DBS, and they considered that it should be the last resort when really needed.

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Section: Introductionmentioning

confidence: 99%

Are Patients Ready for “EARLYSTIM”? Attitudes towards Deep Brain Stimulation among Female and Male Patients with Moderately Advanced Parkinson’s Disease

Sperens

Hamberg

Hariz

2017

Parkinson's Disease

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“…Concerning the effects on cognitive function, a decline in verbal fluency, response inhibition, and memory has been reported [3,4,5,6]. A long-term follow-up study showed a stepwise decrease in verbal fluency and response inhibition during 10 years after surgery compared to a baseline assessment prior to surgery, whereas verbal memory showed an improvement in the first year after surgery and a decrease from 1 to 10 years after surgery [2].…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological Outcome in Subthalamic Nucleus Stimulation Surgeries with Electrodes Passing through the Caudate Nucleus

İşler

Albi²,

Schaper

et al. 2016

Stereotact Funct Neurosurg

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Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) in Parkinson disease (PD) is associated with postoperative cognitive decline. One of the proposed underlying mechanisms is the surgical procedure with the lead trajectory penetrating the caudate nucleus. Objective: To study whether penetration of the caudate nucleus affects neuropsychological outcome. Methods: Neuropsychological and imaging data of 30 PD patients who underwent bilateral STN DBS were analysed. Lead trajectories were evaluated leading to a group with (n = 10) and a group without penetration of the caudate nucleus (n = 20). The neuropsychological performance of each group was compared to baseline, both at 3 and 12 months postoperatively. Results: Only the Trail-Making Test part B (TMT-B) showed an interaction effect within the groups over time at 3 months postoperatively. At 12 months postoperatively, there was only a main effect of time with a decrease in performance in TMT-B for both groups. Also verbal fluency showed a significant decrease over time for both groups at 3 and 12 months postoperatively. Conclusion: Caudate nucleus penetration affects cognitive flexibility only in the short term after surgery.

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“…There is no difference in motor improvement between globus pallidal stimulation and subthalamic stimulation, however, depression deteriorate more in subthalamic stimulation than pallidal stimulation [37]. There is no significant difference in cognition level between subthalamic stimulation and pallidal stimulation [38]. Adverse events of DBS are intraparenchymal haemorrhage, intracerebral infection and decline in verbal fluency [39][40][41].…”

Section: Deep Brain Stimulation (Dbs) Surgerymentioning

confidence: 99%

A Review on Pharmacological Treatment of Idiopathic Parkinson’s Disease

Shah¹

2017

Journal of Neurological Disorders

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Neuropsychological outcome after deep brain stimulation for Parkinson disease

Abstract: This study provides Class I evidence that there is no large difference in neuropsychological outcome between GPi DBS and STN DBS after 12 months. The study lacks the precision to exclude a moderate difference in outcomes.

Cited by 78 publications

References 19 publications

Are Patients Ready for “EARLYSTIM”? Attitudes towards Deep Brain Stimulation among Female and Male Patients with Moderately Advanced Parkinson’s Disease

Are Patients Ready for “EARLYSTIM”? Attitudes towards Deep Brain Stimulation among Female and Male Patients with Moderately Advanced Parkinson’s Disease

Neuropsychological Outcome in Subthalamic Nucleus Stimulation Surgeries with Electrodes Passing through the Caudate Nucleus

A Review on Pharmacological Treatment of Idiopathic Parkinson’s Disease

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