Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: A longitudinal, naturalistic study

Xu, Gaixia; Lin, Kangguang; Rao, Dongping; Dang, Yanan; Ouyang, Huiyi; Guo, Yixin; Ma, Jun; Chen, Jichong

doi:10.1016/j.jad.2011.11.029

Cited by 162 publications

(142 citation statements)

References 57 publications

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“…Unfortunately, no studies to date have performed a cluster analysis of patients with both MDD and BD, despite the similarity in cognitive profiles displayed by these populations (e.g., Xu et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological Clustering in Bipolar and Major Depressive Disorder

Cotrena

Branco

Ponsoni

et al. 2017

J Int Neuropsychol Soc

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Objectives: Cognitive dysfunction is a key feature of major depressive (MDD) and bipolar (BD) disorders. However, rather than a single cognitive profile corresponding to each diagnostic categories, recent studies have identified significant intra-and cross-diagnostic variability in patterns of cognitive impairment. The goal of this study was to contribute to the literature on cognitive heterogeneity in mood disorders by identifying cognitive subprofiles in a population of patients with MDD, BD type I, BD type II, and healthy adults. Methods: Participants completed a neuropsychological battery; scores were converted into Z-scores using normative data and submitted to hierarchical cluster analysis. Results: Three distinct neuropsychological clusters were identified: (1) a large cluster containing mostly control participants, as well as some patients with BD and MDD, who performed at above-average levels on all neuropsychological domains; (2) a cluster containing some patients from all diagnostic groups, as well as healthy controls, who performed worse than cluster 1 on most tasks, and showed impairments in motor inhibition and verbal fluency; (3) a cluster containing mostly patients with mood disorders with severe impairments in verbal inhibition and cognitive flexibility. Conclusions: These findings revealed multiple cognitive profiles within diagnostic categories, as well as significant cross-diagnostic overlap, highlighting the importance of developing more specific treatment approaches which consider patients' demographic and cognitive profiles in addition to their diagnosis. (JINS, 2017, 23, 584-593)

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Section: Introductionmentioning

confidence: 99%

Neuropsychological Clustering in Bipolar and Major Depressive Disorder

Cotrena

Branco

Ponsoni

et al. 2017

J Int Neuropsychol Soc

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“…The neuropsychological literature in patients with bipolar I disorder (BP I) demonstrates impairment during the performance of executive control tasks that is pervasive across all mood states (Malhi et al, 2004(Malhi et al, , 2007Martinez-Aran et al, 2004;Henry et al, 2013). Within the domain of executive function, there is evidence of cognitive dysfunction in subjects with bipolar disorder (BP) specifically during the performance of tasks requiring response inhibition (Martinez-Aran et al, 2004;Swann et al, 2009a;Sole et al, 2011;Xu et al, 2012;Henry et al, 2013). Impairment in inhibitory control performance has been observed in subjects with bipolar disorder during mania and euthymia, and it has been shown to be a significant predictor of functional outcomes, including disability severity, quality of life and occupational functioning (Swann et al, 2009b;Reinares et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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“…[22][23][24] However, during acute depressive episodes, BD-I patients have shown more prominent cognitive impairment compared to unipolar and BD-II patients. 25 This difference may be due to the fact that patients with BD-I report more psychosis than patients with BD-II. 1 In brief, patients with BD experience impairments in various domains of cognition and global functioning, especially during mood episodes.…”

Section: Introductionmentioning

confidence: 99%

Cognition and functioning in bipolar depression

Kapczinski

Narvaez

Magalhães

et al. 2016

Rev. Bras. Psiquiatr.

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Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p o 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.

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Neuropsychological performance in bipolar I, bipolar II and unipolar depression patients: A longitudinal, naturalistic study

Cited by 162 publications

References 57 publications

Neuropsychological Clustering in Bipolar and Major Depressive Disorder

Neuropsychological Clustering in Bipolar and Major Depressive Disorder

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Cognition and functioning in bipolar depression

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