Neuropsychological performance in OCD: A study in medication-naïve patients

Obsessive-compulsive disorder in disguise—Case report

“…Neuropsychological deficits were found among symptomatic and remitted patients as well as in unaffected relatives [10]. Contrary to this Krishna et al did not find any difference between medication-naive patients and healthy controls on a large battery of neuropsychological tests [11]. The lack of change in neuropsychological functioning observed in the present patient may thus be connected to the psychotropic medication itself.…”

Further evidence of a dissociation between decision-making under ambiguity and decision-making under risk in obsessive–compulsive disorder

“…In contrast, other studies found no association between IGT performance and illness severity (Cavedini et al, 2002;da Rocha et al, 2011a;Krishna et al, 2011;Lawrence et al, 2006). This lack of agreement on the relationship between task performance and disease severity may limit the applicability of IGT in clinical use.…”

“…In accordance with the functional alteration of orbitofrontal-striatal circuits, previous studies have frequently demonstrated reduced IGT score in patients with OCD (Cavedini et al, 2002(Cavedini et al, , 2012(Cavedini et al, , 2010da Rocha et al, 2011a;Kashyap et al, 2013;Starcke et al, 2009Starcke et al, , 2010. On the other hand, two studies reported impaired performance in only subgroups of patients with OCD (Lawrence et al, 2006;Nielen et al, 2002), and one study revealed comparable performance in medication-naïve patients with OCD (Krishna et al, 2011). As IGT taps several cognitive processes, it is unclear on which component patients with OCD principally rely to solve the IGT.…”

“…The evidence for a correlation between OCD symptom severity and preference for unfavorable choices is contradictory. While three studies reported positive results (da Rocha et al, 2011b(da Rocha et al, , 2008Nielen et al, 2002), four studies did not (Cavedini et al, 2002;da Rocha et al, 2011a;Krishna et al, 2011;Lawrence et al, 2006). Furthermore, to the best of our knowledge, only two studies were conducted with the GDT (Starcke et al, 2009(Starcke et al, , 2010; patients with OCD in these studies performed similarly compared to controls.…”

Executive Functions of Obsessive Compulsive Disorder and Panic Disorder Patients in Comparison to Healty Controls

“…It has been reported that shortly after the application of clomipramine, patients experience slowness in reaction time, impairment in verbal learning, and remembering (38,39). In a research conducted in India, attention, memory, and executive functions of 31 patients with OCD, who have not received any treatment and do not have recent or past major depression, were compared with healthy controls (40). In this study, executive functions were measured using the Controlled Oral Word Association (FAS) Test, WCST, Stroop Test, and a set of evaluation tools that were not used in the present study.…”