Neuropsychological Performance Is Positively Associated with Plasma Albumin in Healthy Adults

Lam, Virginie; Albrecht, Matthew A.; Takechi, Ryusuke; Heidari-Nejad, Sayeh; Foster, Jonathan; Mamo, John

doi:10.1159/000356967

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…For instance, low serum ALB was found to be independently associated with increased odds of cognitive impairment in the elderly population (39). There was also a positive correlation between ALB and cognitive performance in physiologically healthy participants (40). Conversely, GLO has been reported to increase during chronic inflammation, which has been linked to cognitive decline (3).…”

Section: Discussionmentioning

confidence: 99%

Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults

et al. 2021

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Background: Previous neuroimaging studies have demonstrated brain abnormalities in patients with hepatic diseases. However, the identified liver–brain associations are largely limited to disease-affected populations, and the nature and extent of such relations in healthy subjects remain unclear. We hypothesized that serum liver function markers within a normal level would affect brain properties.Method: One hundred fifty-seven healthy young adults underwent structural, resting-state functional, and arterial spin labeling MRI scans. Gray matter volume (GMV), regional homogeneity (ReHo), and cerebral blood flow (CBF) analyses were performed to assess brain structure, function, and perfusion, respectively. Peripheral venous blood samples were collected to measure serum liver function markers. Correlation analyses were conducted to test potential associations between liver function markers and brain imaging parameters.Results: First, serum proteins showed relations to brain structure characterized by higher albumin associated with increased GMV in the parahippocampal gyrus and amygdala and lower globulin and a higher albumin/globulin ratio with increased GMV in the olfactory cortex and parahippocampal gyrus. Second, serum bilirubin was linked to brain function characterized by higher bilirubin associated with increased ReHo in the precuneus, middle cingulate gyrus, inferior parietal lobule, and supramarginal gyrus and decreased ReHo in the caudate nucleus. Third, serum alanine transaminase (ALT) was related to brain perfusion characterized by higher ALT associated with increased CBF in the superior frontal gyrus and decreased CBF in the middle occipital gyrus, angular gyrus, precuneus, and middle temporal gyrus. More importantly, we found that CBF in the superior frontal gyrus was a significant mediator of the association between serum ALT level and working memory performance.Conclusion: These findings may not only expand existing knowledge about the relationship between the liver and the brain but also have clinical implications for studying brain impairments secondary to liver diseases as well as providing potential neural targets for their diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults

et al. 2021

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“…Bayesian analysis allows the estimation of variables on the basis of background knowledge to generate new information, and estimates can be obtained with MCMC sampling methods using the mean of the posterior distribution [37, 38]. In our study, the relationships between variables were not well known in LBAs, so objective Bayesian methods were used to establish the priors, that all priors could be considered poorly informative for the scale of the data [39]. Therefore, we used uninformative priors, which are believed to have little effect on model estimates [40], so that the data may be allowed to speak for themselves.…”

Section: Methodsmentioning

confidence: 99%

The mediating role of resilience and self-esteem between negative life events and positive social adjustment among left-behind adolescents in China: a cross-sectional study

Gao

Yao

Yao³

et al. 2019

BMC Psychiatry

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Background In China, adolescents are frequently left behind by their parents. A great deal of scientific evidence demonstrates considerable psychological and social impacts that negative life events may have on adolescents who are left behind. While a direct relationship between negative life events and psychological and social effects has been observed, indirect effects have yet to be examined. Therefore, the objective of this study was to determine the association between negative life events and positive social adjustment and how resilience and self-esteem mediate this association. Methods A cross-sectional study was carried out in the provinces of Shandong, Henan, and Sichuan in China. A questionnaire was distributed to 4716 left-behind adolescents in ten middle/high schools. We performed Bayesian estimations in structural equation modeling using the Markov Chain Monte Carlo algorithm to test our hypotheses. Results Negative life events were significantly related to resilience ( r s = − 0.402), self-esteem ( r s = − 0.292), and positive social adjustment ( r s = − 0.239). Positive social adjustment was directly affected by resilience ( β = 0.639) and self-esteem ( β = 0.448). Negative life events were not only directly related to positive social adjustment ( β = − 0.187, 95% credible interval: − 0.233 ~ − 0.139), but also showed an indirect effect on positive social adjustment ( β = − 0.541, 95% credible interval: − 0.583 ~ − 0.501) through resilience ( β = − 0.370) and self-esteem ( β = − 0.171). The total effect of negative life events on positive social adjustment was − 0.728, where 74.31% was mediated by resilience and self-esteem. The indirect effect of negative life events on positive social adjustment through resilience and self-esteem was 2.893 times more than the direct effect. Conclusions Resilience and self-esteem mediated most of the effect of negative life events on positive social adjustment. Interventions should be developed to improve the social adjustment of adolescents who are left behind, particularly the enhancement of resilience and self-esteem. Electronic supplementary material The online version of this article (10.1186/s12888-019-2219-z) contains supplementary material, which is available to authorized users.

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“…Several studies in both healthy and clinical populations have reported associations between cognitive functioning and serum albumin levels [ 61 , 63 – 67 , 99 – 106 ]; some specifically noting relations between lower serum albumin and deteriorated memory performance [ 107 ]. Indeed, HIV mono-infected [ 108 ] and HIV + HCV co-infected [ 109 ] individuals with cognitive impairment, including disturbed visual memory in HIV + HCV-coinfection [ 110 ], have low serum albumin.…”

Section: Discussionmentioning

confidence: 99%

Serum albumin and white matter hyperintensities

Zahr,

Pfefferbaum

2024

Transl Psychiatry

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People living with HIV and those diagnosed with alcohol use disorders (AUD) relative to healthy individuals commonly have low levels of serum albumin, substantiated as an independent predictor of cardiovascular events. White matter hyperintensities (WMH)—a neuroimaging feature of cerebral small vessel disease—are also related to cardiovascular disease. Despite consensus regarding associations between high levels of urine albumin and WMH prevalence, and low serum albumin levels and impaired cognitive functioning, relations between serum albumin and WMH burdens have rarely been evaluated. Here, a sample including 160 individuals with AUD, 142 living with HIV, and 102 healthy controls was used to test the hypothesis that serum albumin would be inversely related to WMH volumes and directly related to cognitive performance in the two diagnostic groups. Although serum albumin and periventricular WMH volumes showed an inverse relationship in both AUD and HIV groups, this relationship persisted only in the HIV group after consideration of traditional cardiovascular (i.e., age, sex, body mass index (BMI), nicotine use, hypertension, diabetes), study-relevant (i.e., race, socioeconomic status, hepatitis C virus status), and disease-specific (i.e., CD4 nadir, HIV viral load, HIV duration) factors. Further, serum albumin contributed more significantly than periventricular WMH volume to variance in performance on a verbal learning and memory composite score in the HIV group only. Relations in both HIV and AUD groups between albumin and hematological red blood cell markers (e.g., hemoglobin, hematocrit) suggest that in this sample, serum albumin reflects hematological abnormalities. Albumin, a simple serum biomarker available in most clinical settings, may therefore help identify periventricular WMH burden and performance levels in specific cognitive domains in people living with HIV. Whether serum albumin contributes mechanistically to periventricular WMH in HIV will require additional investigation.

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Neuropsychological Performance Is Positively Associated with Plasma Albumin in Healthy Adults

Cited by 4 publications

References 68 publications

Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults

Associations of Serum Liver Function Markers With Brain Structure, Function, and Perfusion in Healthy Young Adults

The mediating role of resilience and self-esteem between negative life events and positive social adjustment among left-behind adolescents in China: a cross-sectional study

Serum albumin and white matter hyperintensities

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