Neuropsychological presentation of colpocephaly and porencephaly with symptom onset in adulthood

Colpocephaly in an adult: A rare case report

“…Out of these 3 cases, only 1 patient was diagnosed with colpocephaly with normal brain parenchyma [14] . The other 2 cases were associated with porencephaly [15] and an absent circle of Willis [10] .…”

“…Review of current literature suggests colpocephaly is often an incidental diagnosis in adults. Adult patients usually present with nonspecific symptoms such as headache [1 , 2 , 3 , 10] , dizziness [2 , 6] , seizures [6 , 11] , vertigo [1] , nausea [6] , motor abnormalities [16] , sensory abnormalities [12] , cognitive abnormalities [15 , 17] , intellectual disability [18] , learning disability [17] , gait instability and falls [9] , loss of consciousness [13] and visual hallucinations [19] . Gungor et al reported a case with postmortem diagnosis of colpocephaly in a patient with a lifelong history of poor academic performance [20] .…”

Colpocefalia en adulto

“…1 Por lo general se diagnostica durante la infancia, de manera que en la edad adulta es extremadamente raro, incluso en la última publicación encontrada se reportan sólo nueve pacientes. 2 Principalmente se asocia a anomalías del sistema motor, discapacidad intelectual, defectos visuales, dificultades del habla y lenguaje; en muy pocos casos cursa de manera asintomática. 1 Existen múltiples etiologías que pueden estar relacionadas con este desarrollo anormal del sistema nervioso central (SNC), entre las que se encuentran: lesiones intrauterinas y perinatales, desórdenes genéticos y errores en la morfogénesis.…”