Neuropsychological Problems after Paediatric Stroke: Two Year Follow-Up of Swiss Children

Pavlovic, J; Kaufmann, Franz; Boltshauser, Eugen; Mori, Andrea; Mercati, Danielle; Haenggeli, Charles-Antoine; Keller, E; Lütschg, Jürg; Jp, Marcoz; Gp, Ramelli; Perez, E. Roulet; Schmitt‐Mechelke, Thomas; Weissert, M; Steinlin, Maja

doi:10.1055/s-2006-923932

Cited by 98 publications

(79 citation statements)

References 36 publications

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“…The requirement that these abilities be intact was a limiting factor for the number of patients in the study. Sequelae are generally common and intense in stroke patients, as shown in the literature [1][2][3][4][5] . In the free recall stage of the dichotic non-verbal test, the SG identified more items with one ear than the other.…”

Section: Discussionmentioning

confidence: 88%

Stroke caused auditory attention deficits in children

Elias

Moura-Ribeiro

2013

Arq. Neuro-Psiquiatr.

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OBJECTIVE: To verify the auditory selective attention in children with stroke. METHODS: Dichotic tests of binaural separation (non-verbal and consonant-vowel) and binaural integration - digits and Staggered Spondaic Words Test (SSW) - were applied in 13 children (7 boys), from 7 to 16 years, with unilateral stroke confirmed by neurological examination and neuroimaging. RESULTS: The attention performance showed significant differences in comparison to the control group in both kinds of tests. In the non-verbal test, identifications the ear opposite the lesion in the free recall stage was diminished and, in the following stages, a difficulty in directing attention was detected. In the consonant- vowel test, a modification in perceptual asymmetry and difficulty in focusing in the attended stages was found. In the digits and SSW tests, ipsilateral, contralateral and bilateral deficits were detected, depending on the characteristics of the lesions and demand of the task. CONCLUSION: Stroke caused auditory attention deficits when dealing with simultaneous sources of auditory information.

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Section: Discussionmentioning

confidence: 88%

Stroke caused auditory attention deficits in children

Elias

Moura-Ribeiro

2013

Arq. Neuro-Psiquiatr.

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“…Previous studies by our group 13,15 included 10 and 22 AIS children, respectively. Children were excluded from this analysis for the following reasons: death (n 5 12), did not report for follow-up (n 5 39), preexisting conditions that influence cognition such as trisomy 21 (n 5 6), and use of a test that was not part of the predefined assessment battery (n 5 3).…”

Section: Methods Participant Population the Swiss Neuropediatricsmentioning

confidence: 99%

“…[7][8][9][10] However, younger age at stroke is associated with poorer intellectual outcome and a broader spectrum of dysfunctions across multiple neuropsychological domains. 6,[11][12][13][14][15][16][17] Further, children with combined cortical and subcortical lesions have overall poorer cognitive outcome, 16,18 and larger lesion size negatively influences cognitive and functional outcome, 4,19,20 possibly due to disruption of more neural network connections, adversely affecting functional brain organization. 21 Regarding lesion laterality, controversial reports exist concerning the effect of lesion laterality on neuropsychological outcome.…”

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confidence: 99%

“…21 Regarding lesion laterality, controversial reports exist concerning the effect of lesion laterality on neuropsychological outcome. [11][12][13]15,16,22 In addition, persistent seizures 10,22 and persistent NI such as hemiplegia/paresis or visual field deficits also negatively influence neuropsychological and functional outcome. 5,11,19 The main goal of this study was to examine the influence of age, lesion characteristics, seizures, NI, and functional outcome on cognitive outcome in a population-based group of children 2 years after an AIS occurrence.…”

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confidence: 99%

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Factors affecting cognitive outcome in early pediatric stroke

et al. 2014

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OBJECTIVE: We examined cognitive performance in children after stroke to study the influence of age at stroke, seizures, lesion characteristics, neurologic impairment (NI), and functional outcome on cognitive outcome. METHODS: This was a prospectively designed study conducted in 99 children who sustained an arterial ischemic stroke (AIS) between the age of 1 month and 16 years. All children underwent cognitive and neurologic follow-up examination sessions 2 years after the insult. Cognitive development was assessed with age-appropriate instruments. RESULTS: Although mean cognitive performance was in the lower normative range, we found poorer results in subtests measuring visuoconstructive skills, short-term memory, and processing speed. Risk factors for negative cognitive outcome were young age at stroke, seizures, combined lesion location (cortical and subcortical), as well as marked NI. CONCLUSIONS: We recommend that all children with a history of AIS undergo regularly scheduled neuropsychological assessment to ensure implementation of appropriate interventions and environmental adjustments as early as possible. Factors affecting cognitive outcome in early pediatric stroke ABSTRACT Objective: We examined cognitive performance in children after stroke to study the influence of

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“…There is considerable evidence that an early brain insult is associated with a broad spectrum of neuropsychological dysfunction [57,58]. In fact, the onset of stroke at a younger age predisposes to an overall worse prognosis [59][60][61], weaker cognitive performance, and is subject to lesion location [62].…”

Section: Predictors Of Long-term Neurodevelopmen-tal Outcome Followinmentioning

confidence: 99%

Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Perinatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview

Zammit

Muscat

Sani³

et al. 2015

CPD

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Recent advances in medical care have significantly improved the survival rate of neonates who suffer a hypoxic/ischemic event, before, during, or after birth. These infants are extremely vulnerable to brain injury and are at high risk of developing motor and cognitive abnormalities later on in life. The regional distribution of perinatal brain injury varies, and depends primarily on; the severity, pattern and type of insult, the metabolic status, and on the gestational age. The principal neuropathological substrate that is affected in the premature infant is cerebral white matter. The aim of this article is to reexamine the current knowledge on the ischemic pathophysiology of all cellular components that comprise the white matter, predict the consequences of the long-term neurological outcome, and analyze possible therapeutic strategies. Although oligodendrocytes have long been regarded as the hallmark of perinatal white matter injury, axons, astrocytes and microglia, all contribute to the complex pattern of brain injury that occurs in this cohort of individuals. It is hoped that a better understanding of the pathophysiology of white matter injury and its underlying prognostic factors, may lead to the development of new therapeutic strategies for such a complex and debilitating condition.

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Neuropsychological Problems after Paediatric Stroke: Two Year Follow-Up of Swiss Children

Abstract: After paediatric stroke neuropsychological problems are present in about 75% of children. Younger age at stroke as well as an emergence of epilepsy were predictors for worse prognosis.

Cited by 98 publications

References 36 publications

Stroke caused auditory attention deficits in children

Stroke caused auditory attention deficits in children

Factors affecting cognitive outcome in early pediatric stroke

Cerebral White Matter Injuries Following a Hypoxic/Ischemic Insult During the Perinatal Period: Pathophysiology, Prognostic Factors, and Future Strategy of Treatment Approach. A Minireview

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