Neuropsychological Profile in Early-Onset Schizophrenia-Spectrum Disorders: Measured With the MATRICS Battery

Holmén, Aina; Juuhl-Langseth, Monica; Thormodsen, Rune; Melle, Ingrid; Rund, Bjørn Rishovd

doi:10.1093/schbul/sbn174

Cited by 94 publications

(85 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite this, we have controlled for IQ and SES differences through further analysis of covariance. As has been found in previous reports, our results showed that cognitive deficits are a relevant trait of EOS beyond patients' lower IQ and lower SES [32,38,57]. Regarding academic grade, our results confirmed previous reports which showed that EOS patients achieve worse educational level [3,61] and showed that such worse achievements were present from initial stages of the illness independently from IQ and SES.…”

Section: Discussionsupporting

confidence: 91%

“…Although it may be a controversial issue, groups were not matched by IQ, academic grade or SES. As EOS is associated with compromised general cognitive intellectual ability [36] and schizophrenia is associated with low socioeconomic status, especially in patients with low cognitive abilities [60], matching the groups in these areas could actually remove the effect of the disease, leading to biased comparisons between overachieving patients and underachieving controls [20,38]. Despite this, we have controlled for IQ and SES differences through further analysis of covariance.…”

Section: Discussionmentioning

confidence: 99%

“…Also, at the premorbid stage of the illness, early onset is related to greater IQ decrement [37]. Therefore, differences in IQ could be considered an inherent effect of the disorder rather than a confounding variable [20,38]. The groups were not matched by academic grade because this variable was analyzed as a real-world outcome.…”

Section: Samplementioning

confidence: 99%

“…To provide a standard metric for comparisons across cognitive domains and controlling for age and developmental effects, scores were converted to demographically corrected T-scores. Cognitive domains were defined following the MATRICS consensus battery [40] which has been recently validated in adolescents with EOS [38]. Since a Spanish translation of the battery is not yet ready, available tests in Spanish that are similar to the consensus were used to assess cognitive domains.…”

Section: Cognition Measuresmentioning

confidence: 99%

See 3 more Smart Citations

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Puig

Penadés

Baeza

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Cognition and clinical variables are known to be among the most predictive factors of real-world social functioning and daily living skills in adult-onset schizophrenia. Fewer studies have focused on their impact in adolescents with early-onset schizophrenia (EOS). The aim of this study is to examine the relationships and the predictive value of cognition and clinical variables on real-world daily living skills in a sample of adolescents with EOS. Cognitive, clinical and real-world everyday living skills measures were administered to 45 clinically and pharmacologically stabilized adolescent outpatients with EOS and 45 healthy control subjects matched by age and sex. Multi-variant analyses to compare cognitive and real-world functioning profiles between patients and controls and regression analysis to identify predictors of real-world functioning scores in patients were used. Adolescents with EOS showed a generalized cognitive and real-world daily living skills dysfunction. Several cognitive and clinical variables significantly correlated with real-world daily living skills functioning but only the processing speed and executive functions emerged as independent predictors of everyday living skills scores, explaining 25.1% of the variance. Slowness in processing information and executive dysfunction showed a significant impact on real-world daily living skills in EOS, independently from clinical symptoms and other cognitive variables. Nevertheless, much of the variance in the daily living skills measure remained unaccounted for, suggesting that other factors were involved as well in this young population.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Samplementioning

confidence: 99%

Section: Cognition Measuresmentioning

confidence: 99%

See 2 more Smart Citations

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Puig

Penadés

Baeza

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

show abstract

“…The overall long term outcomes in area of social and vocational domains remain unfavourable [1]. Cognitive impairment precedes the emergence of positive and negative symptoms and appears to persist throughout the course of the disorder [2,3]. Expert consensus concludes that the negative outcomes are strongly related to the severity of impaired neuro-cognition (INC).…”

Section: Introductionmentioning

confidence: 99%

Exploring Standardized Zembrin® Extracts from the South African plant Sceletium tortuosum in Dual Targeting Phosphodiesterase-4 (PDE-4) and Serotonin Reuptake Inhibition as potential treatment in Schizophrenia

Chiu¹

2017

IJCAM

View full text Add to dashboard Cite

Identification of ANKK1 rs1800497 variant in schizophrenia: New data and meta‐analysis

Zhang

Fan

et al. 2014

American J of Med Genetics Pt B

View full text Add to dashboard Cite

One functional polymorphism (rs1800497) within the ankyrin repeat and kinase domain containing-1 gene (ANKK1) was reported to be associated with schizophrenia, but results among different studies vary and conclusions remain controversial. The present study sought to clarify this potential association among a population of Han Chinese with early onset schizophrenia using a case-control (396 patients and 399 controls) and family based study (103 trios). We then performed a meta-analysis (comprising 11 case-control and 2 family-based studies) based on the present literature. Results of the association study revealed no significant difference in allele and genotype frequencies between the cases and controls, and no significant transmission distortion was detected. Kaplan-Meier survival analysis showed that age at onset in schizophrenia was significantly associated with the rs1800497 polymorphism in female patients, but not in males. Female T allele carriers had a lower age at onset than those without T allele (log rank statistic χ(2) = 5.16, P = 0.023; corrected P = 0.046). Meta-analysis results indicated that rs1800497 is not associated with schizophrenia in the overall population (P = 0.77 for the case-control studies; P = 0.06 for the family-based studies). Our results support the hypothesis that rs1800497 polymorphism is likely to have a modifying rather than causative effect on schizophrenia. These findings may represent a significant genetic clue for the etiology of schizophrenia in females, but further investigation is required to clarify the exact role of ANKK1 in the development of schizophrenia.

show abstract

Neuropsychological Profile in Early-Onset Schizophrenia-Spectrum Disorders: Measured With the MATRICS Battery

Cited by 94 publications

References 38 publications

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Exploring Standardized Zembrin® Extracts from the South African plant Sceletium tortuosum in Dual Targeting Phosphodiesterase-4 (PDE-4) and Serotonin Reuptake Inhibition as potential treatment in Schizophrenia

Identification of ANKK1 rs1800497 variant in schizophrenia: New data and meta‐analysis

Contact Info

Product

Resources

About