Neuropsychological profile of Brazilian older adults with heterogeneous educational backgrounds

YASSUDA, M; DINIZ, B; FLAKS, M; Pereira, Felipe Barbosa; VIOLA, L; NUNES, P; FORLENZA, O

doi:10.1016/j.acn.2008.09.008

Cited by 34 publications

(56 citation statements)

References 40 publications

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“…Controversially to our results, another study conducted in Brazil 8 showed that brief batteries could accurately discriminate MCI from normal and demented individuals, although not sensitively enough to establish subtypes of MCI (e.g., amnestic, non-amnestic or multiple domain). Our findings suggest that, at least in a sample that mirror clinical everyday clinical practice (i.e., clinical-control individuals, MCI and individuals with dementia), the use of this brief battery should be restricted to the purpose of determining less specific groups, such as: 1) individuals with no decline versus individuals with cognitive decline (normal versus MCI plus AD); or 2) individuals without AD (MCI plus normal individuals) from individuals with AD.…”

Section: Discussioncontrasting

confidence: 41%

“…Some studies in Brazil have proposed new neuropsychological batteries and brief screening tools for the diagnosis of both MCI and dementia [8][9][10][11] . Some studies have investigated single tests or existing batteries, such as the Clock Drawing Test (CDT) 12 , the Mini-Mental State Examination (MMSE) and the Cambridge Mental Disorders of the Elderly Examination (CAMDEX).…”

Section: Introductionmentioning

confidence: 99%

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Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery?

Coutinho¹,

Oliveira‐Souza²,

Moll³

et al. 2013

Rev. psiquiatr. clín.

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Background: Distinguishing individuals with dementia from those with mild cognitive impairment (MCI) might demand a neuropsychological evaluation. Methods: One hundred and thirty-one consecutive referred elderly patients (37 clinical-controls, 41 with amnestic MCI and 53 with possible/probable AD) were diagnosed with a comprehensive (full) neuropsychological battery, MRI and clinical data. All of the results were blindly coded and evaluated latter with a subset of the tests to reclassify the subjects as MCI, dementia or clinical-control. Agreement rates between both batteries were calculated. We also used ROC curves to establish the sensitivity and specificity of the brief battery for discriminating (i) clinical-control individuals from a group dementia and MCI patients; (ii) individuals with dementia from individuals without dementia; (iii) clinical-control individuals from a group of MCI. We compared performance of the three groups on all full battery tasks. Results: All neuropsychological tests showed differences between clinical-control and dementia groups. The comparison between MCI and the other groups mainly showed memory differences. Agreement between brief and full batteries was substantial (kappa = 0.805). Analyses with ROC curves showed good sensitivity and specificity to discriminate non-demented (clinical control plus MCI groups) and AD group and also to discriminate clinical-control individuals from individuals with cognitive decline (MCI plus AD group). However, sensitivity and specificity significantly decreased when brief battery was tested to discriminate only normal and MCI diagnosis. Discussion: The use of a brief battery might not be indicated to discriminate MCI and clinical-control individuals, but its use might be adequate to discriminate less specific groups (demented versus non-demented and pathological [dementia and MCI] and non-pathological [clinical-control] groups).

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Section: Discussioncontrasting

confidence: 41%

Section: Introductionmentioning

confidence: 99%

Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery?

Coutinho¹,

Oliveira‐Souza²,

Moll³

et al. 2013

Rev. psiquiatr. clín.

View full text Add to dashboard Cite

show abstract

“…1,28 Evidence of objective memory impairment was defined as performance bellow 1.5 standard deviation in the memory tests (RBMT and/or FOME), adjusted for age and educational status. 29 Subjects without evidence of cognitive impairment were included in the control group.…”

Section: Diagnosismentioning

confidence: 99%

Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment

Forlenza

Diniz

Talib

et al. 2010

Rev. Bras. Psiquiatr.

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Preditores clínicos e biológicos da evolução para doença de AbstractObjective: To identify predictors of the progression from pre-dementia stages of cognitive impairment in Alzheimer's disease is relevant to clinical management and to substantiate the decision of prescribing antidementia drugs. Method: Longitudinal study of a cohort of elderly adults with amnestic mild cognitive impairment and healthy controls, carried out to estimate the risk and characterize predictors of the progression to Alzheimer's disease. Results: Patients with amnestic mild cognitive impairment had a higher risk to develop Alzheimer's disease during followup (odds ratio = 4.5, CI 95% [1.3-13.6], p = 0.010). At baseline, older age, lower scores on memory tests and presence of the APOE*4 allele predicted the progression from amnestic mild cognitive impairment to Alzheimer's disease. In a sub sample of amnestic mild cognitive impairment patients, those who progressed to Alzheimer's disease had lower cerebrospinal fluid concentrations of amyloid-beta peptide (Aβ 42 , p = 0.020) and higher concentrations of total TAU (p = 0.030) and phosphorylated TAU (p = 0.010), as compared to non-converters. Discussion: This is the first Brazilian study to report cerebrospinal fluid biomarkers in the prediction of the conversion from MCI to Alzheimer's disease. Our data are in accordance with those reported in other settings. The measurement of cerebrospinal fluid total-TAU, phospho-TAU and Aβ 42 may help identify patients with mild cognitive impairment at higher risk for developing Alzheimer's disease. [1,3-13,6], p = 0,012 Descriptors

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“…Diniz et al 22 evaluated elderly community residents and found statistically significant correlations between MMSE and age (rho = 0.232, p = 0.003) and education (rho = 0.471, p < 0.0001) and a significant correlation linked to sex, with men having better outcomes than women. Yassuda et al 48 studied the effect of formal education in a neuropsychological assessment battery comparing groups with different educational levels and reported that formal education is correlated with most of the instruments (MMSE, CAMCOG, Trail Making Test Part B, Vocabulary and Block Design, WAIS-R and Short Cognitive Performance Test) although no significant correlation with the Verbal Fluency Test was found. .…”

Section: Discussionmentioning

confidence: 99%

“…These findings will enhance future clinical studies on the protocol's applicability in the Brazilian population. Given its importance, the GC construct should be investigated further and additional measures included such as: socioeconomic status, income, educational level and occupational level 48 .…”

Section: Discussionmentioning

confidence: 99%

Propriedades psicométricas de um protocolo neuropsicológico breve para uso em populações geriátricas

Paula¹,

Schlottfeldt²,

Moreira³

et al. 2010

Rev. psiquiatr. clín.

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Background: The increase in life expectancy and proportion of elderly in the population is causing an increase in dementia prevalence rates. The correct, early diagnosis of dementia is very important to clinical treatment and to improved prognosis. Therefore, it is necessary to adapt and develop assessment tools for the differential diagnosis between pathological and normal aging processes. Objective: Assess the psychometric properties and the factorial structure of a neuropsychological protocol used in geriatric assessment. Method: Subjects (n = 69) with heterogeneous cognitive complaints were assessed at the Centro de Geriatria e Gerontologia at the Hospital das Clínicas da Universidade Federal de Minas Gerais using a protocol composed of the Mini-Mental State Examination, Clock Drawing, Corsi Blocks, Verbal Fluency, Digit Span and Token Test. Statistical analyses included factorial analyses of test results, Pearson's correlation between obtained factor, age, years of formal education and clinical dementia rating and area under the ROC curve. Results: The factorial analyses of test scores showed a general representative factor that had moderate and significant association with CDR (r = -0.672; p < 0.001) and years of formal education (r = 0.455; p < 0.001), respectively. This factor had weaker and less significant correlation with age (r = -0.282; p < 0.05). Discussion: These results point to the protocol's good construct and criteria validity in assessing cognitive decline in the elderly. Future works concerning applicability and populational norms are needed to improve the clinical use of this assessment protocol.

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Neuropsychological profile of Brazilian older adults with heterogeneous educational backgrounds

Cited by 34 publications

References 40 publications

Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery?

Is it possible to identify individuals with mild cognitive impairment and Alzheimer's disease using a 30-minute neuropsychological battery?

Clinical and biological predictors of Alzheimer's disease in patients with amnestic mild cognitive impairment

Propriedades psicométricas de um protocolo neuropsicológico breve para uso em populações geriátricas

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