Neuropsychological Profile of Specific Executive Dysfunctions in Patients with Deficit and Non-deficit Schizophrenia

Tyburski, Ernest; Pełka-Wysiecka, Justyna; Mak, Monika; Samochowiec, Agnieszka; Bieńkowski, Przemysław; Samochowiec, Jerzy

doi:10.3389/fpsyg.2017.01459

Cited by 20 publications

(25 citation statements)

References 81 publications

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“…Patients characterized as DS in our study scored higher on the following items: blunted affect, emotional withdrawal, poor rapport, passive apathetic social withdrawal, lack of spontaneity, motor retardation, and active social avoidance (i.e., the negative items according to Shafer et al [ 14 ]). This is in line with other studies on the psychopathological characteristics of DS patients [ 72 , 73 , 74 ]. The participants in our group did not differ significantly in terms of age, gender, or in the number of psychotic exacerbations or interruptions to treatment.…”

Section: Discussionsupporting

confidence: 93%

White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

Podwalski

Tyburski

Szczygieł

et al. 2021

JCM

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Deficit syndrome (DS) is a subtype of schizophrenia characterized by primary persistent negative symptoms. The corpus callosum (CC) appears to be related to psychopathology in schizophrenia. This study assessed white matter integrity in the CC using diffusion tensor imaging (DTI) in deficit and non-deficit schizophrenia (NDS) patients. We also investigated the psychopathological dimensions of schizophrenia and their relationship to CC integrity. Fifteen DS patients, 40 NDS patients, and 30 healthy controls (HC) underwent psychiatric evaluation and neuroimaging. We divided the CC into five regions and assessed their fractional anisotropy (FA) and mean diffusivity (MD). Psychopathology was assessed with the Positive and Negative Syndrome Scale. DS patients had lower FA than NDS patients and HC, and higher MD in Region 5 of the CC than did HC. NDS patients had higher MD in Region 4 of the CC. The patient groups differed in terms of negative symptoms. After differentiating clinical groups and HC, no significant correlations were observed between DTI measures and psychopathological symptoms. Our results suggest that DS and NDS are characterized by minor impairments of the posterior CC. We confirmed that DS patients have greater negative psychopathology than NDS patients. Our results are preliminary, and further studies are needed.

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Section: Discussionsupporting

confidence: 93%

White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

Podwalski

Tyburski

Szczygieł

et al. 2021

JCM

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“…The Auditory Verbal Learning Test (AVLT) and AVLT-delay recall (AVLT-DR) were used to assess memory, with higher scores representing better memory. The Trail Making Test (TMT) and Stroop Color Word Test (SCWT) were used to assess executive abilities [27][28][29]. The longer consuming time indicated worse executive performance.…”

Section: Neuropsychological Testingmentioning

confidence: 99%

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Huang

Yang

et al. 2020

Endocrine

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Purpose To identify the volume changes of hippocampus subfields in T2DM patients with cognitive impairment and to determine how these atrophy patterns associate with impairments in different cognitive domain. Methods A total of 117 individuals were recruited, including T2DM patients with cognitive impairment (T2DM-CI) (n = 34), T2DM patients without cognitive impairment (T2DM-non-CI) (n = 36) and normal controls (NC) (n = 47). All subjects went through a 3.0 T magnetic resonance (MR) scan and a neuropsychological assessment. Hippocampal subfield volumes were processed using the FreeSurfer 6.0.0 and compared among the three groups. Partial correlation analyses were used to estimate the relationship between cognitive function and hippocampal subfield volume, with age, sex, education, and eTIV (estimated total intracranial volume) as covariants. Results The total hippocampal volume had a reduction trend among the three groups, and the significantly statistical difference only was found between T2DM-CI group and NC group. Regarding the hippocampal subfields, the volumes of left subiculum, left presubiculum, left fimbria, right CA1 and right molecular layer HP decreased significantly in the T2DM-CI group (P < 0.05/12). Partial correlation analyses showed that the volumes of the left subiculum, left fimbria, and left presubiculum were significantly related to executive function. The right hippocampal CA1 volume was significantly correlated with memory in the T2DM-CI group (P < 0.05). But in T2DM-non-CI group, the correlation between the left fimbria volume and the memory, the left subiculum volume and MoCA were different with the T2DM-CI group and NC group (P < 0.05). Conclusions The smaller the volume of left presubiculum, the worse the executive function, and the atrophy of the right CA1 was related to memory impairment in T2DM-CI group. However the result was the opposite in T2DM-non-CI group. There might be a compensation mechanism of hippocampus of T2DM patients before cognitive impairment.

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“…Based on clinical symptoms, medical history of functional impairment, and the Schedule for the Deficit Syndrome (SDS) outcome, the sample was divided into two subgroups: (1) patients with deficit (DS), and (2) non-deficit schizophrenia (NDS) [88][89][90][91][92]. The SDS ratings were made on a five-point scale, based on the primary or secondary character, persistence and intensity of each of the following six negative symptoms: restricted affect, diminished emotional range, poverty of speech, curbing of interests, diminished sense of purpose, diminished social drive.…”

Section: The Samplementioning

confidence: 99%

Association between DRD2 and ANKK1 polymorphisms with the deficit syndrome in schizophrenia

et al. 2020

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Background:The clinical course of schizophrenia varies among patients and is difficult to predict. Some patient populations present persistent negative symptoms, referred to as the deficit syndrome. Compared to relatives of non-deficit schizophrenia patients, family members of this patient population are at an increased risk of developing schizophrenia. Therefore, the aim of this study was to search for genetic underpinnings of the deficit syndrome in schizophrenia.Methods: Three SNPs, i.e., rs1799732 and rs6276 located within DRD2, and rs1800497 within ANKK1, were identified in the DNA samples of 198 schizophrenia probands, including 103 patients with deficit (DS) and 95 patients with non-deficit schizophrenia (NDS). Results: No significant differences concerning any of the analyzed polymorphisms were found between DS and NDS patients. However, significant links were observed between family history of schizophrenia and the deficit syndrome, G/G genotype and rs6276 G allele. In a separate analysis, we identified significant differences in frequencies of rs6276 G allele between DS and NDS patients with family history of schizophrenia. No significant associations were found between DRD2 and ANKK1 SNPs and the age of onset or schizophrenia symptom severity. Conclusions:The results of our preliminary study fail to provide evidence of associations between DRD2 and ANKK1 polymorphisms with the deficit syndrome or schizophrenia symptom severity, but suggest potential links between rs6276 in DRD2 and the deficit syndrome in patients with hereditary susceptibility to schizophrenia. However, further studies are necessary to confirm this observation.

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Neuropsychological Profile of Specific Executive Dysfunctions in Patients with Deficit and Non-deficit Schizophrenia

Cited by 20 publications

References 81 publications

White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

White Matter Integrity of the Corpus Callosum and Psychopathological Dimensions in Deficit and Non-Deficit Schizophrenia Patients

Atrophy patterns of hippocampal subfields in T2DM patients with cognitive impairment

Association between DRD2 and ANKK1 polymorphisms with the deficit syndrome in schizophrenia

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